A PRDX1‐p38α heterodimer amplifies MET‐driven invasion of IDH‐wildtype and IDH‐mutant gliomas

The Peroxiredoxin 1 (PRDX1) gene maps to chromosome arm 1p and is hemizygously deleted and epigenetically silenced in isocitrate dehydrogenase 1 or 2 (IDH)‐mutant and 1p/19q‐codeleted oligodendroglial tumors. In contrast, IDH‐wildtype astrocytic gliomas including glioblastomas mostly lack epigenetic...

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Veröffentlicht in:	International journal of cancer 2018-09, Vol.143 (5), p.1176-1187
Hauptverfasser:	Wirthschaft, Peter, Bode, Julia, Simon, Anika E.M., Hoffmann, Elisa, van Laack, Rebecca, Krüwel, Thomas, Dietrich, Fabio, Bucher, Delia, Hahn, Artur, Sahm, Felix, Breckwoldt, Michael O., Kurz, Felix T., Hielscher, Thomas, Fischer, Bernd, Dross, Nicolas, Ruiz de Almodovar, Carmen, von Deimling, Andreas, Herold‐Mende, Christel, Plass, Christoph, Boulant, Steeve, Wiestler, Benedikt, Reifenberger, Guido, Lichter, Peter, Wick, Wolfgang, Tews, Björn
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animal models Animals Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors c-Met protein Cancer Cell adhesion & migration Cell migration Cell Movement Cell Proliferation Cytoskeleton c‐MET Data processing Follow-Up Studies Gene expression Gene mapping Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Glioma cells gliomas Hepatocyte growth factor Humans invasion Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Kinases Male Medical research Mice Mice, Nude Mitogen-Activated Protein Kinase 14 - genetics Mitogen-Activated Protein Kinase 14 - metabolism Mutation Neoplasm Invasiveness p38α Peroxiredoxin peroxiredoxin 1 Peroxiredoxins - genetics Peroxiredoxins - metabolism Prognosis Protein kinase Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Signal transduction Survival Rate Tumor Cells, Cultured Xenograft Model Antitumor Assays
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