Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design
Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the r...
Gespeichert in:
| Veröffentlicht in: | Calcified tissue international 2018-09, Vol.103 (3), p.246-251 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 251 |
|---|---|
| container_issue | 3 |
| container_start_page | 246 |
| container_title | Calcified tissue international |
| container_volume | 103 |
| creator | Wu, Long-Fei Zhu, Dong-Cheng Tang, Chang-Hua Ge, Bing Shi, Ju Wang, Bing-Hua Lu, Yi-Hua He, Pei Wang, Wen-Yu Lu, Si-Qi Zhong, Jiao Zhou, Xu Zhu, Kan Ji, Wen Gao, Hong-Qin Gu, Hong-Bo Mo, Xing-Bo Lu, Xin Zhang, Lei Zhang, Yong-Hong Deng, Fei-Yan Lei, Shu-Feng |
| description | Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (
N
= 6308), two subgroups with extremely high and low hip BMD were selected for discovery (
N
= 80, high vs. low BMD = 44:36) and validation (
N
= 60, high vs. low BMD = 30:30), respectively. Plasma irisin, P1NP, and β-CTx were measured using commercially available ELISA kits. Other metabolic parameters (e.g., blood glucose, total cholesterol and triglycerides) were collected. Student’s
t
test and Spearman correlation analyses were conducted in SPSS. Significant difference was discovered for plasma irisin between females and age-matched males (
N
= 80, male vs. female = 42:38,
P
= 0.002). The plasma irisin levels were significantly higher in high BMD subjects than in low BMD subjects, which was observed in both discovery (
P
= 0.012) and validation samples (
P
= 0.022). However, such observation was limited to males only. Further correlation analyses in males showed that plasma irisin was correlated with BMD (
r
= 0.362,
P
= 0.025) and triglyceride (
r
= − 0.354,
P
= 0.032). Plasma irisin levels were associated with hip BMD in Chinese elderly men. This study represented the first effort of investigating the relationship of plasma irisin and BMD in elderly population. The positive correlation between plasma irisin and BMD hints intrinsic communication between muscle and bone. |
| doi_str_mv | 10.1007/s00223-018-0415-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2019044828</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2018432576</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-d53d037009e207fdbd2d4ac740866a2e09cab6339126ae51264585c1a2d702a13</originalsourceid><addsrcrecordid>eNp1kUFr3DAQhUVpSbZpf0AvQZBLLm5HI1uyj8kmbQNbGmgDvQmtPbtRsKWNZJPk31eLkxYKvWhA73tPYh5jHwR8FAD6UwJAlAWIuoBSVIV8xRailFhAjfo1W4DQomiU_nXI3qZ0ByBKpdQBO8SmqlFIXLDpLKXQOju64HnY8OvepsHyq-iS8_zBjbf8PHji35ynaHt-QT658Yln0fKVjVviy9usJeLXYTf1c9BNNm-59fzycYw0EP9hh12_v7ug5Lb-HXuzsX2i98_ziN18vvy5_Fqsvn-5Wp6tilZqHIuukh1IDdAQgt506w670ra6hFopiwRNa9dKykagslTls6zqqhUWOw1ohTxip3PuLob7idJoBpda6nvrKUzJIIgGyrLGOqMn_6B3YYo-_25P1XmrlVaZEjPVxpBSpI3ZRTfY-GQEmH0nZu7EZIvZd2Jk9hw_J0_rgbo_jpcSMoAzkLLktxT_Pv3_1N8QWJVx</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2018432576</pqid></control><display><type>article</type><title>Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design</title><source>SpringerLink Journals - AutoHoldings</source><creator>Wu, Long-Fei ; Zhu, Dong-Cheng ; Tang, Chang-Hua ; Ge, Bing ; Shi, Ju ; Wang, Bing-Hua ; Lu, Yi-Hua ; He, Pei ; Wang, Wen-Yu ; Lu, Si-Qi ; Zhong, Jiao ; Zhou, Xu ; Zhu, Kan ; Ji, Wen ; Gao, Hong-Qin ; Gu, Hong-Bo ; Mo, Xing-Bo ; Lu, Xin ; Zhang, Lei ; Zhang, Yong-Hong ; Deng, Fei-Yan ; Lei, Shu-Feng</creator><creatorcontrib>Wu, Long-Fei ; Zhu, Dong-Cheng ; Tang, Chang-Hua ; Ge, Bing ; Shi, Ju ; Wang, Bing-Hua ; Lu, Yi-Hua ; He, Pei ; Wang, Wen-Yu ; Lu, Si-Qi ; Zhong, Jiao ; Zhou, Xu ; Zhu, Kan ; Ji, Wen ; Gao, Hong-Qin ; Gu, Hong-Bo ; Mo, Xing-Bo ; Lu, Xin ; Zhang, Lei ; Zhang, Yong-Hong ; Deng, Fei-Yan ; Lei, Shu-Feng</creatorcontrib><description>Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (
N
= 6308), two subgroups with extremely high and low hip BMD were selected for discovery (
N
= 80, high vs. low BMD = 44:36) and validation (
N
= 60, high vs. low BMD = 30:30), respectively. Plasma irisin, P1NP, and β-CTx were measured using commercially available ELISA kits. Other metabolic parameters (e.g., blood glucose, total cholesterol and triglycerides) were collected. Student’s
t
test and Spearman correlation analyses were conducted in SPSS. Significant difference was discovered for plasma irisin between females and age-matched males (
N
= 80, male vs. female = 42:38,
P
= 0.002). The plasma irisin levels were significantly higher in high BMD subjects than in low BMD subjects, which was observed in both discovery (
P
= 0.012) and validation samples (
P
= 0.022). However, such observation was limited to males only. Further correlation analyses in males showed that plasma irisin was correlated with BMD (
r
= 0.362,
P
= 0.025) and triglyceride (
r
= − 0.354,
P
= 0.032). Plasma irisin levels were associated with hip BMD in Chinese elderly men. This study represented the first effort of investigating the relationship of plasma irisin and BMD in elderly population. The positive correlation between plasma irisin and BMD hints intrinsic communication between muscle and bone.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-018-0415-3</identifier><identifier>PMID: 29582132</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adipose tissue ; Adipose tissue (brown) ; Biochemistry ; Biomedical and Life Sciences ; Bone density ; Bone mineral density ; Bone turnover ; Cell Biology ; Cholesterol ; Collagen ; Endocrinology ; Enzyme-linked immunosorbent assay ; Geriatrics ; Hip ; Life Sciences ; Males ; Original Research ; Orthopedics ; Osteoporosis ; Plasma ; Population ; Population density ; Sampling ; Skeletal muscle ; Triglycerides</subject><ispartof>Calcified tissue international, 2018-09, Vol.103 (3), p.246-251</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Calcified Tissue International is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d53d037009e207fdbd2d4ac740866a2e09cab6339126ae51264585c1a2d702a13</citedby><cites>FETCH-LOGICAL-c372t-d53d037009e207fdbd2d4ac740866a2e09cab6339126ae51264585c1a2d702a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-018-0415-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-018-0415-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29582132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Long-Fei</creatorcontrib><creatorcontrib>Zhu, Dong-Cheng</creatorcontrib><creatorcontrib>Tang, Chang-Hua</creatorcontrib><creatorcontrib>Ge, Bing</creatorcontrib><creatorcontrib>Shi, Ju</creatorcontrib><creatorcontrib>Wang, Bing-Hua</creatorcontrib><creatorcontrib>Lu, Yi-Hua</creatorcontrib><creatorcontrib>He, Pei</creatorcontrib><creatorcontrib>Wang, Wen-Yu</creatorcontrib><creatorcontrib>Lu, Si-Qi</creatorcontrib><creatorcontrib>Zhong, Jiao</creatorcontrib><creatorcontrib>Zhou, Xu</creatorcontrib><creatorcontrib>Zhu, Kan</creatorcontrib><creatorcontrib>Ji, Wen</creatorcontrib><creatorcontrib>Gao, Hong-Qin</creatorcontrib><creatorcontrib>Gu, Hong-Bo</creatorcontrib><creatorcontrib>Mo, Xing-Bo</creatorcontrib><creatorcontrib>Lu, Xin</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Zhang, Yong-Hong</creatorcontrib><creatorcontrib>Deng, Fei-Yan</creatorcontrib><creatorcontrib>Lei, Shu-Feng</creatorcontrib><title>Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (
N
= 6308), two subgroups with extremely high and low hip BMD were selected for discovery (
N
= 80, high vs. low BMD = 44:36) and validation (
N
= 60, high vs. low BMD = 30:30), respectively. Plasma irisin, P1NP, and β-CTx were measured using commercially available ELISA kits. Other metabolic parameters (e.g., blood glucose, total cholesterol and triglycerides) were collected. Student’s
t
test and Spearman correlation analyses were conducted in SPSS. Significant difference was discovered for plasma irisin between females and age-matched males (
N
= 80, male vs. female = 42:38,
P
= 0.002). The plasma irisin levels were significantly higher in high BMD subjects than in low BMD subjects, which was observed in both discovery (
P
= 0.012) and validation samples (
P
= 0.022). However, such observation was limited to males only. Further correlation analyses in males showed that plasma irisin was correlated with BMD (
r
= 0.362,
P
= 0.025) and triglyceride (
r
= − 0.354,
P
= 0.032). Plasma irisin levels were associated with hip BMD in Chinese elderly men. This study represented the first effort of investigating the relationship of plasma irisin and BMD in elderly population. The positive correlation between plasma irisin and BMD hints intrinsic communication between muscle and bone.</description><subject>Adipose tissue</subject><subject>Adipose tissue (brown)</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Bone density</subject><subject>Bone mineral density</subject><subject>Bone turnover</subject><subject>Cell Biology</subject><subject>Cholesterol</subject><subject>Collagen</subject><subject>Endocrinology</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Geriatrics</subject><subject>Hip</subject><subject>Life Sciences</subject><subject>Males</subject><subject>Original Research</subject><subject>Orthopedics</subject><subject>Osteoporosis</subject><subject>Plasma</subject><subject>Population</subject><subject>Population density</subject><subject>Sampling</subject><subject>Skeletal muscle</subject><subject>Triglycerides</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFr3DAQhUVpSbZpf0AvQZBLLm5HI1uyj8kmbQNbGmgDvQmtPbtRsKWNZJPk31eLkxYKvWhA73tPYh5jHwR8FAD6UwJAlAWIuoBSVIV8xRailFhAjfo1W4DQomiU_nXI3qZ0ByBKpdQBO8SmqlFIXLDpLKXQOju64HnY8OvepsHyq-iS8_zBjbf8PHji35ynaHt-QT658Yln0fKVjVviy9usJeLXYTf1c9BNNm-59fzycYw0EP9hh12_v7ug5Lb-HXuzsX2i98_ziN18vvy5_Fqsvn-5Wp6tilZqHIuukh1IDdAQgt506w670ra6hFopiwRNa9dKykagslTls6zqqhUWOw1ohTxip3PuLob7idJoBpda6nvrKUzJIIgGyrLGOqMn_6B3YYo-_25P1XmrlVaZEjPVxpBSpI3ZRTfY-GQEmH0nZu7EZIvZd2Jk9hw_J0_rgbo_jpcSMoAzkLLktxT_Pv3_1N8QWJVx</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Wu, Long-Fei</creator><creator>Zhu, Dong-Cheng</creator><creator>Tang, Chang-Hua</creator><creator>Ge, Bing</creator><creator>Shi, Ju</creator><creator>Wang, Bing-Hua</creator><creator>Lu, Yi-Hua</creator><creator>He, Pei</creator><creator>Wang, Wen-Yu</creator><creator>Lu, Si-Qi</creator><creator>Zhong, Jiao</creator><creator>Zhou, Xu</creator><creator>Zhu, Kan</creator><creator>Ji, Wen</creator><creator>Gao, Hong-Qin</creator><creator>Gu, Hong-Bo</creator><creator>Mo, Xing-Bo</creator><creator>Lu, Xin</creator><creator>Zhang, Lei</creator><creator>Zhang, Yong-Hong</creator><creator>Deng, Fei-Yan</creator><creator>Lei, Shu-Feng</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20180901</creationdate><title>Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design</title><author>Wu, Long-Fei ; Zhu, Dong-Cheng ; Tang, Chang-Hua ; Ge, Bing ; Shi, Ju ; Wang, Bing-Hua ; Lu, Yi-Hua ; He, Pei ; Wang, Wen-Yu ; Lu, Si-Qi ; Zhong, Jiao ; Zhou, Xu ; Zhu, Kan ; Ji, Wen ; Gao, Hong-Qin ; Gu, Hong-Bo ; Mo, Xing-Bo ; Lu, Xin ; Zhang, Lei ; Zhang, Yong-Hong ; Deng, Fei-Yan ; Lei, Shu-Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d53d037009e207fdbd2d4ac740866a2e09cab6339126ae51264585c1a2d702a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adipose tissue</topic><topic>Adipose tissue (brown)</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Bone density</topic><topic>Bone mineral density</topic><topic>Bone turnover</topic><topic>Cell Biology</topic><topic>Cholesterol</topic><topic>Collagen</topic><topic>Endocrinology</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Geriatrics</topic><topic>Hip</topic><topic>Life Sciences</topic><topic>Males</topic><topic>Original Research</topic><topic>Orthopedics</topic><topic>Osteoporosis</topic><topic>Plasma</topic><topic>Population</topic><topic>Population density</topic><topic>Sampling</topic><topic>Skeletal muscle</topic><topic>Triglycerides</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Long-Fei</creatorcontrib><creatorcontrib>Zhu, Dong-Cheng</creatorcontrib><creatorcontrib>Tang, Chang-Hua</creatorcontrib><creatorcontrib>Ge, Bing</creatorcontrib><creatorcontrib>Shi, Ju</creatorcontrib><creatorcontrib>Wang, Bing-Hua</creatorcontrib><creatorcontrib>Lu, Yi-Hua</creatorcontrib><creatorcontrib>He, Pei</creatorcontrib><creatorcontrib>Wang, Wen-Yu</creatorcontrib><creatorcontrib>Lu, Si-Qi</creatorcontrib><creatorcontrib>Zhong, Jiao</creatorcontrib><creatorcontrib>Zhou, Xu</creatorcontrib><creatorcontrib>Zhu, Kan</creatorcontrib><creatorcontrib>Ji, Wen</creatorcontrib><creatorcontrib>Gao, Hong-Qin</creatorcontrib><creatorcontrib>Gu, Hong-Bo</creatorcontrib><creatorcontrib>Mo, Xing-Bo</creatorcontrib><creatorcontrib>Lu, Xin</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Zhang, Yong-Hong</creatorcontrib><creatorcontrib>Deng, Fei-Yan</creatorcontrib><creatorcontrib>Lei, Shu-Feng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Calcified tissue international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Long-Fei</au><au>Zhu, Dong-Cheng</au><au>Tang, Chang-Hua</au><au>Ge, Bing</au><au>Shi, Ju</au><au>Wang, Bing-Hua</au><au>Lu, Yi-Hua</au><au>He, Pei</au><au>Wang, Wen-Yu</au><au>Lu, Si-Qi</au><au>Zhong, Jiao</au><au>Zhou, Xu</au><au>Zhu, Kan</au><au>Ji, Wen</au><au>Gao, Hong-Qin</au><au>Gu, Hong-Bo</au><au>Mo, Xing-Bo</au><au>Lu, Xin</au><au>Zhang, Lei</au><au>Zhang, Yong-Hong</au><au>Deng, Fei-Yan</au><au>Lei, Shu-Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>103</volume><issue>3</issue><spage>246</spage><epage>251</epage><pages>246-251</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>Irisin, a myokine produced by skeletal muscle in response to physical exercise, promotes trans-differentiation of white adipose tissue into brown adipose tissue. Recent evidences suggested that irisin also plays an important role in the control of bone metabolism. This study aimed to ascertain the relationship between plasma irisin and bone mineral density (BMD) in Chinese population by adoption of an extreme sampling method. Based on a large and screened Chinese elderly population (
N
= 6308), two subgroups with extremely high and low hip BMD were selected for discovery (
N
= 80, high vs. low BMD = 44:36) and validation (
N
= 60, high vs. low BMD = 30:30), respectively. Plasma irisin, P1NP, and β-CTx were measured using commercially available ELISA kits. Other metabolic parameters (e.g., blood glucose, total cholesterol and triglycerides) were collected. Student’s
t
test and Spearman correlation analyses were conducted in SPSS. Significant difference was discovered for plasma irisin between females and age-matched males (
N
= 80, male vs. female = 42:38,
P
= 0.002). The plasma irisin levels were significantly higher in high BMD subjects than in low BMD subjects, which was observed in both discovery (
P
= 0.012) and validation samples (
P
= 0.022). However, such observation was limited to males only. Further correlation analyses in males showed that plasma irisin was correlated with BMD (
r
= 0.362,
P
= 0.025) and triglyceride (
r
= − 0.354,
P
= 0.032). Plasma irisin levels were associated with hip BMD in Chinese elderly men. This study represented the first effort of investigating the relationship of plasma irisin and BMD in elderly population. The positive correlation between plasma irisin and BMD hints intrinsic communication between muscle and bone.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29582132</pmid><doi>10.1007/s00223-018-0415-3</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-967X |
| ispartof | Calcified tissue international, 2018-09, Vol.103 (3), p.246-251 |
| issn | 0171-967X 1432-0827 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2019044828 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Adipose tissue Adipose tissue (brown) Biochemistry Biomedical and Life Sciences Bone density Bone mineral density Bone turnover Cell Biology Cholesterol Collagen Endocrinology Enzyme-linked immunosorbent assay Geriatrics Hip Life Sciences Males Original Research Orthopedics Osteoporosis Plasma Population Population density Sampling Skeletal muscle Triglycerides |
| title | Association of Plasma Irisin with Bone Mineral Density in a Large Chinese Population Using an Extreme Sampling Design |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T19%3A56%3A11IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20of%20Plasma%20Irisin%20with%20Bone%20Mineral%20Density%20in%20a%20Large%20Chinese%20Population%20Using%20an%20Extreme%20Sampling%20Design&rft.jtitle=Calcified%20tissue%20international&rft.au=Wu,%20Long-Fei&rft.date=2018-09-01&rft.volume=103&rft.issue=3&rft.spage=246&rft.epage=251&rft.pages=246-251&rft.issn=0171-967X&rft.eissn=1432-0827&rft_id=info:doi/10.1007/s00223-018-0415-3&rft_dat=%3Cproquest_cross%3E2018432576%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2018432576&rft_id=info:pmid/29582132&rfr_iscdi=true |