Discovery of a Novel Highly Selective Histamine H4 Receptor Antagonist for the Treatment of Atopic Dermatitis

The histamine H4 receptor (H4R), a member of the G-protein coupled receptor family, has been considered as a potential therapeutic target for treating atopic dermatitis (AD). A large number of H4R antagonists have been disclosed, but no efficient agents controlling both pruritus and inflammation in...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-04, Vol.61 (7), p.2949-2961
Hauptverfasser:	Ko, Kwangseok, Kim, Hye-Jung, Ho, Pil-Su, Lee, Soon Ok, Lee, Ji-Eun, Min, Cho-Rong, Kim, Yu Chul, Yoon, Ju-Han, Park, Eun-Jung, Kwon, Young-Jin, Yun, Jee-Hun, Yoon, Dong-Oh, Kim, Jung-Sook, Park, Woul-Seong, Oh, Seung-Su, Song, Yu-Mi, Cho, Woon-Ki, Morikawa, Kazumi, Lee, Kyoung-June, Park, Chan-Hee
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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