Hyfraxins A and B, cytotoxic ergostane-type steroid and lanostane triterpenoid glycosides from the invasive ash dieback ascomycete Hymenoscyphus fraxineus

[Display omitted] •A new steroidal glycoside and a related glycosylated triterpenoid were identified.•Producer is the ash dieback pathogen Hymenoscyphus fraxineus.•Their stereochemistry was assigned including absolute configuration.•Both compounds exhibited cytotoxic activity against the murine cell...

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Veröffentlicht in:	Steroids 2018-07, Vol.135, p.92-97
Hauptverfasser:	Surup, Frank, Halecker, Sandra, Nimtz, Manfred, Rodrigo, Sara, Schulz, Barbara, Steinert, Michael, Stadler, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Infective Agents - toxicity Ascomycota - chemistry Ash dieback Cell Line Cytotoxic activity Cytotoxins - chemistry Cytotoxins - pharmacology Cytotoxins - toxicity Ergosterol - analogs & derivatives Ergosterol - chemistry Ergosterol - pharmacology Ergosterol - toxicity Glycosides - chemistry Glycosides - pharmacology Glycosides - toxicity Hymenoscyphus fraxineus Lanosterol - analogs & derivatives Lanosterol - chemistry Mice Secondary metabolites Steroid glycoside Triterpenes - chemistry Triterpenoid glycoside
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