Soy undecapeptide induces Drosophila hind leg grooming via dopamine receptor
β-Conglycinin α subunit (323-333) [βCGα(323-333)] is an exogenous neuromodulating undecapeptide found from enzymatic digest of β-conglycinin, a soy major storage protein by mice behavior tests. We investigated effect of βCGα(323-333) on Drosophila behavior. Oral administration of βCGα(323-333) in Dr...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2018-05, Vol.499 (3), p.454-458 |
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| creator | Karim, M. Rezaul Yanagawa, Aya Ohinata, Kousaku |
| description | β-Conglycinin α subunit (323-333) [βCGα(323-333)] is an exogenous neuromodulating undecapeptide found from enzymatic digest of β-conglycinin, a soy major storage protein by mice behavior tests. We investigated effect of βCGα(323-333) on Drosophila behavior. Oral administration of βCGα(323-333) in Drosophila increased hind leg grooming, which may act through specific sets of neurons. It was reported that dopamine receptor (DopR) meditates hind leg grooming, and we tested involvement of DopR in βCGα(323-333)-induced hind leg grooming by using DopR knockout flies. In the wild type but not in the DopR-knockout flies, βCGα(323-333) increased hind leg grooming. These results suggest that βCGα(323-333) induces hind leg grooming via activating the DopR. This is the first report showing that exogenously administered peptide changes fly behaviors.
•Oral administration of soy peptide βCGα(323-333) in Drosophila increased hind leg grooming.•βCGα(323-333) induces hind leg grooming via activating the DopR.•The first example that exogenously administered peptide changes fly behaviors. |
| doi_str_mv | 10.1016/j.bbrc.2018.03.162 |
| format | Article |
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•Oral administration of soy peptide βCGα(323-333) in Drosophila increased hind leg grooming.•βCGα(323-333) induces hind leg grooming via activating the DopR.•The first example that exogenously administered peptide changes fly behaviors.</description><subject>Animals</subject><subject>Antigens, Plant - pharmacology</subject><subject>Behavior</subject><subject>Dopamine receptor</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - drug effects</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophila Proteins - metabolism</subject><subject>Extremities - physiology</subject><subject>Gene Knockdown Techniques</subject><subject>Globulins - pharmacology</subject><subject>Glycine max - chemistry</subject><subject>Grooming - drug effects</subject><subject>Oligopeptides - pharmacology</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Seed Storage Proteins - pharmacology</subject><subject>Soy peptide</subject><subject>Soybean Proteins - pharmacology</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVoSNwkL9BD0bGX3cxIu1ov9BLSpA0YckgKvQlJO7Zl1qut5DXk7SvXTo89DTN8_w_zMfYJoURAdbsprY2uFIDzEmSJSpyxGUILhUCoPrAZAKhCtPjrkn1MaQOAWKn2gl2Ktm6aFtSMLV7CG5-GjpwZadz5jrgfuslR4t9iSGFc-97wdb7xnlZ8FUPY-mHF997wLowmL8QjuZwN8ZqdL02f6OY0r9jPx4fX-x_F4vn70_3donCyVrtCuEYBNkbUqoFKCrC2ElYQ1lXbSnQoG3DWLJ3EGgTMqSIlu9Zasuiq2sgr9uXYO8bwe6K001ufHPW9GShMSR-M5Op5Pc-oOKIuf5MiLfUY_dbEN42gDxb1Rh8s_s1okDpbzKHPp_7Jbqn7F3nXloGvR4Dyl3tPUSfnaXDU-exip7vg_9f_B-lBgtc</recordid><startdate>20180515</startdate><enddate>20180515</enddate><creator>Karim, M. 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Rezaul</creatorcontrib><creatorcontrib>Yanagawa, Aya</creatorcontrib><creatorcontrib>Ohinata, Kousaku</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karim, M. Rezaul</au><au>Yanagawa, Aya</au><au>Ohinata, Kousaku</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Soy undecapeptide induces Drosophila hind leg grooming via dopamine receptor</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2018-05-15</date><risdate>2018</risdate><volume>499</volume><issue>3</issue><spage>454</spage><epage>458</epage><pages>454-458</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>β-Conglycinin α subunit (323-333) [βCGα(323-333)] is an exogenous neuromodulating undecapeptide found from enzymatic digest of β-conglycinin, a soy major storage protein by mice behavior tests. We investigated effect of βCGα(323-333) on Drosophila behavior. Oral administration of βCGα(323-333) in Drosophila increased hind leg grooming, which may act through specific sets of neurons. It was reported that dopamine receptor (DopR) meditates hind leg grooming, and we tested involvement of DopR in βCGα(323-333)-induced hind leg grooming by using DopR knockout flies. In the wild type but not in the DopR-knockout flies, βCGα(323-333) increased hind leg grooming. These results suggest that βCGα(323-333) induces hind leg grooming via activating the DopR. This is the first report showing that exogenously administered peptide changes fly behaviors.
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| subjects | Animals Antigens, Plant - pharmacology Behavior Dopamine receptor Drosophila Drosophila melanogaster - drug effects Drosophila melanogaster - physiology Drosophila Proteins - metabolism Extremities - physiology Gene Knockdown Techniques Globulins - pharmacology Glycine max - chemistry Grooming - drug effects Oligopeptides - pharmacology Receptors, Dopamine - metabolism Seed Storage Proteins - pharmacology Soy peptide Soybean Proteins - pharmacology |
| title | Soy undecapeptide induces Drosophila hind leg grooming via dopamine receptor |
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