Quantification of ligand density and stoichiometry on the surface of liposomes using single-molecule fluorescence imaging

Despite the longstanding existence of liposome technology in drug delivery applications, there have been no ligand-directed liposome formulations approved for clinical use to date. This lack of translation is due to several factors, one of which is the absence of molecular tools for the robust quant...

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Veröffentlicht in:	Journal of controlled release 2018-05, Vol.278, p.80-86
Hauptverfasser:	Belfiore, Lisa, Spenkelink, Lisanne M., Ranson, Marie, van Oijen, Antoine M., Vine, Kara L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Functionalized liposomes Ligand quantification Molecular characterization Single-molecule fluorescence microscopy
Online-Zugang:	Volltext
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