fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images
Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into “pleasant” and “unpleasant” subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the m...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2018-03, Vol.164 (5), p.601-604 |
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| creator | Mel’nikov, M. E. Petrovskii, E. D. Bezmaternykh, D. D. Kozlova, L. I. Shtark, M. B. Savelov, A. A. Shubina, O. S. Natarova, K. A. |
| description | Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into “pleasant” and “unpleasant” subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the motor regions (precentral and postcentral gyrus) and in the cerebellum (
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| doi_str_mv | 10.1007/s10517-018-4040-y |
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p
<0.05 with FWE correction). Most likely, these clusters are associated with motion (pressing a button in accordance with the instruction). According to the data of intergroup contrasts, patients with depression had less pronounced activation of frontal structures (middle frontal gyrus and other areas, including the white matter) in response to both positive and negative images (
p
<0.001). In healthy subjects, the response of the temporo-occipital areas (lingual and fusiform gyrus) to unpleasant stimuli was more intensive than in patients (
p
<0.001). This can be due to differences in the semantic image processing. Thus, in case of mild depression, the response of the amygdaloid complex, the key structure in the development in affective disorder, was not always observed. At the same time, the response of frontal and temporo-occipital regions has a certain potential as a biomarker of mild depression, although the reliability of the obtained data requires additional confirmation.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-018-4040-y</identifier><identifier>PMID: 29577204</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Amygdala ; Biomarkers ; Biomedical and Life Sciences ; Biomedicine ; Brain - physiology ; Brain Mapping ; Cell Biology ; Cerebellum ; Depression ; Depression (Mood disorder) ; Emotions - physiology ; Female ; Frontal gyrus ; Functional magnetic resonance imaging ; Humans ; Image processing ; Information processing ; Internal Medicine ; Laboratory Medicine ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Mental depression ; Pathology ; Postcentral gyrus ; Substantia alba</subject><ispartof>Bulletin of experimental biology and medicine, 2018-03, Vol.164 (5), p.601-604</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Springer</rights><rights>Bulletin of Experimental Biology and Medicine is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-a60f4540330fa933b4da110fecdfa4ec584a5610f003736bae118a7a08c87f013</citedby><cites>FETCH-LOGICAL-c470t-a60f4540330fa933b4da110fecdfa4ec584a5610f003736bae118a7a08c87f013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-018-4040-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-018-4040-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29577204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mel’nikov, M. E.</creatorcontrib><creatorcontrib>Petrovskii, E. D.</creatorcontrib><creatorcontrib>Bezmaternykh, D. D.</creatorcontrib><creatorcontrib>Kozlova, L. I.</creatorcontrib><creatorcontrib>Shtark, M. B.</creatorcontrib><creatorcontrib>Savelov, A. A.</creatorcontrib><creatorcontrib>Shubina, O. S.</creatorcontrib><creatorcontrib>Natarova, K. A.</creatorcontrib><title>fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into “pleasant” and “unpleasant” subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the motor regions (precentral and postcentral gyrus) and in the cerebellum (
p
<0.05 with FWE correction). Most likely, these clusters are associated with motion (pressing a button in accordance with the instruction). According to the data of intergroup contrasts, patients with depression had less pronounced activation of frontal structures (middle frontal gyrus and other areas, including the white matter) in response to both positive and negative images (
p
<0.001). In healthy subjects, the response of the temporo-occipital areas (lingual and fusiform gyrus) to unpleasant stimuli was more intensive than in patients (
p
<0.001). This can be due to differences in the semantic image processing. Thus, in case of mild depression, the response of the amygdaloid complex, the key structure in the development in affective disorder, was not always observed. At the same time, the response of frontal and temporo-occipital regions has a certain potential as a biomarker of mild depression, although the reliability of the obtained data requires additional confirmation.</description><subject>Amygdala</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain - physiology</subject><subject>Brain Mapping</subject><subject>Cell Biology</subject><subject>Cerebellum</subject><subject>Depression</subject><subject>Depression (Mood disorder)</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Frontal gyrus</subject><subject>Functional magnetic resonance imaging</subject><subject>Humans</subject><subject>Image processing</subject><subject>Information processing</subject><subject>Internal Medicine</subject><subject>Laboratory Medicine</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Mental depression</subject><subject>Pathology</subject><subject>Postcentral gyrus</subject><subject>Substantia alba</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kt9v1DAMxysEYsfgD-AFRUJCvHQ4TdrkHqfxYydt4jSx5yjXOneZ2uSo26GT9scv3W2MIVAeEtsff2U7zrK3HI44gPpEHEqucuA6lyAh3z3LZrxUItdFwZ9nM0hQLrXWB9kroqvJhIq_zA6KealUAXKW3bjziwW7QNrGQEjMB3aKth02O7YIjb_2zWhbYjY0U2hpB49hIPbLDxt27tuGfcZtj0Q-BjZEtkzvBCQs2dGxZYuWbBjuBC7D9sFcdHaN9Dp74ZI6vrm_D7PLr19-nJzmZ9-_LU6Oz_JaKhhyW4GTpQQhwNm5ECvZWM7BYd04K7EutbRllRwAQolqZZFzbZUFXWvlgIvD7ONed9vHnyPSYDpPNbatDRhHMkWaYFVpNS8T-v4v9CqOfUjVTZTSoiykfqTWtkXjg4tDb-tJ1ByXMtUmRFUl6ugfVDoNdr6OAZ1P_icJH_5I2Nz9A8V2nKZJT0G-B-s-EvXozLb3ne13hoOZVsPsV8Okxsy0GmaXct7ddzauOmx-ZzzsQgKKPUApFNbYP7b-f9VbeaLB1A</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Mel’nikov, M. 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E. ; Petrovskii, E. D. ; Bezmaternykh, D. D. ; Kozlova, L. I. ; Shtark, M. B. ; Savelov, A. A. ; Shubina, O. S. ; Natarova, K. 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E.</creatorcontrib><creatorcontrib>Petrovskii, E. D.</creatorcontrib><creatorcontrib>Bezmaternykh, D. D.</creatorcontrib><creatorcontrib>Kozlova, L. I.</creatorcontrib><creatorcontrib>Shtark, M. B.</creatorcontrib><creatorcontrib>Savelov, A. A.</creatorcontrib><creatorcontrib>Shubina, O. S.</creatorcontrib><creatorcontrib>Natarova, K. 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E.</au><au>Petrovskii, E. D.</au><au>Bezmaternykh, D. D.</au><au>Kozlova, L. I.</au><au>Shtark, M. B.</au><au>Savelov, A. A.</au><au>Shubina, O. S.</au><au>Natarova, K. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2018-03-01</date><risdate>2018</risdate><volume>164</volume><issue>5</issue><spage>601</spage><epage>604</epage><pages>601-604</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>Patients with mild depression and apparently healthy individuals were presented images and asked to sort them into “pleasant” and “unpleasant” subsets. In both groups, the main differences between brain activation patterns during presentation of pleasant and unpleasant images were localized in the motor regions (precentral and postcentral gyrus) and in the cerebellum (
p
<0.05 with FWE correction). Most likely, these clusters are associated with motion (pressing a button in accordance with the instruction). According to the data of intergroup contrasts, patients with depression had less pronounced activation of frontal structures (middle frontal gyrus and other areas, including the white matter) in response to both positive and negative images (
p
<0.001). In healthy subjects, the response of the temporo-occipital areas (lingual and fusiform gyrus) to unpleasant stimuli was more intensive than in patients (
p
<0.001). This can be due to differences in the semantic image processing. Thus, in case of mild depression, the response of the amygdaloid complex, the key structure in the development in affective disorder, was not always observed. At the same time, the response of frontal and temporo-occipital regions has a certain potential as a biomarker of mild depression, although the reliability of the obtained data requires additional confirmation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>29577204</pmid><doi>10.1007/s10517-018-4040-y</doi><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Amygdala Biomarkers Biomedical and Life Sciences Biomedicine Brain - physiology Brain Mapping Cell Biology Cerebellum Depression Depression (Mood disorder) Emotions - physiology Female Frontal gyrus Functional magnetic resonance imaging Humans Image processing Information processing Internal Medicine Laboratory Medicine Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Mental depression Pathology Postcentral gyrus Substantia alba |
| title | fMRI Responses in Healthy Individuals and in Patients with Mild Depression to Presentation of Pleasant and Unpleasant Images |
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