Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion
To assess if infusion of human bone marrow–derived stem cells (BMDSCs) could promote follicle development in patients with impaired ovarian functions. Experimental design. University research laboratories. Immunodeficient NOD/SCID female mice. Human BMDSCs were injected into mice with chemotherapy-i...
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| Veröffentlicht in: | Fertility and sterility 2018-05, Vol.109 (5), p.908-918.e2 |
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| creator | Herraiz, Sonia Buigues, Anna Díaz-García, César Romeu, Mónica Martínez, Susana Gómez-Seguí, Inés Simón, Carlos Hsueh, Aaron J. Pellicer, Antonio |
| description | To assess if infusion of human bone marrow–derived stem cells (BMDSCs) could promote follicle development in patients with impaired ovarian functions.
Experimental design.
University research laboratories.
Immunodeficient NOD/SCID female mice.
Human BMDSCs were injected into mice with chemotherapy-induced ovarian damage and into immunodeficient mice xenografted with human cortex from poor-responder patients (PRs).
Follicle development, ovulation, and offspring. Apoptosis, proliferation, and vascularization were evaluated in mouse and human ovarian stroma.
Fertility rescue and spontaneous pregnancies were achieved in mice ovaries mimicking PRs and ovarian insufficiency, induced by chemotherapy, after BMDSC infusion. Furthermore, BMDSC treatment resulted in production of higher numbers of preovulatory follicles, metaphase II oocytes, 2-cell embryos, and healthy pups. Stem cells promoted ovarian vascularization and cell proliferation, along with reduced apoptosis. In xenografted human ovarian tissues from PRs, infusion of BMDSCs and their CD133+ fraction led to their engraftment close to follicles, resulting in promotion of follicular growth, increases in E2 secretion, and enhanced local vascularization.
Our results raised the possibility that promoting ovarian angiogenesis by BMDSC infusion could be an alternative approach to improve follicular development in women with impaired ovarian function.
NCT02240342. |
| doi_str_mv | 10.1016/j.fertnstert.2018.01.004 |
| format | Article |
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Experimental design.
University research laboratories.
Immunodeficient NOD/SCID female mice.
Human BMDSCs were injected into mice with chemotherapy-induced ovarian damage and into immunodeficient mice xenografted with human cortex from poor-responder patients (PRs).
Follicle development, ovulation, and offspring. Apoptosis, proliferation, and vascularization were evaluated in mouse and human ovarian stroma.
Fertility rescue and spontaneous pregnancies were achieved in mice ovaries mimicking PRs and ovarian insufficiency, induced by chemotherapy, after BMDSC infusion. Furthermore, BMDSC treatment resulted in production of higher numbers of preovulatory follicles, metaphase II oocytes, 2-cell embryos, and healthy pups. Stem cells promoted ovarian vascularization and cell proliferation, along with reduced apoptosis. In xenografted human ovarian tissues from PRs, infusion of BMDSCs and their CD133+ fraction led to their engraftment close to follicles, resulting in promotion of follicular growth, increases in E2 secretion, and enhanced local vascularization.
Our results raised the possibility that promoting ovarian angiogenesis by BMDSC infusion could be an alternative approach to improve follicular development in women with impaired ovarian function.
NCT02240342.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2018.01.004</identifier><identifier>PMID: 29576341</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Bone Marrow Cells - physiology ; Bone Marrow Transplantation - methods ; Bone marrow–derived stem cell infusion ; Female ; follicle rescue ; Humans ; Infertility, Female - diagnosis ; Infertility, Female - therapy ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Ovarian Follicle - growth & development ; ovarian niche regeneration ; poor ovarian response ; primary ovarian insufficiency ; Stem Cell Transplantation - methods ; Stem Cells - physiology</subject><ispartof>Fertility and sterility, 2018-05, Vol.109 (5), p.908-918.e2</ispartof><rights>2018 American Society for Reproductive Medicine</rights><rights>Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-eb7c1c960c9dc7beea82c00a941dd0cb2703b4e29260e6f9565b8c6af74f4d523</citedby><cites>FETCH-LOGICAL-c424t-eb7c1c960c9dc7beea82c00a941dd0cb2703b4e29260e6f9565b8c6af74f4d523</cites><orcidid>0000-0003-0703-6922</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028218300049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29576341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Herraiz, Sonia</creatorcontrib><creatorcontrib>Buigues, Anna</creatorcontrib><creatorcontrib>Díaz-García, César</creatorcontrib><creatorcontrib>Romeu, Mónica</creatorcontrib><creatorcontrib>Martínez, Susana</creatorcontrib><creatorcontrib>Gómez-Seguí, Inés</creatorcontrib><creatorcontrib>Simón, Carlos</creatorcontrib><creatorcontrib>Hsueh, Aaron J.</creatorcontrib><creatorcontrib>Pellicer, Antonio</creatorcontrib><title>Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>To assess if infusion of human bone marrow–derived stem cells (BMDSCs) could promote follicle development in patients with impaired ovarian functions.
Experimental design.
University research laboratories.
Immunodeficient NOD/SCID female mice.
Human BMDSCs were injected into mice with chemotherapy-induced ovarian damage and into immunodeficient mice xenografted with human cortex from poor-responder patients (PRs).
Follicle development, ovulation, and offspring. Apoptosis, proliferation, and vascularization were evaluated in mouse and human ovarian stroma.
Fertility rescue and spontaneous pregnancies were achieved in mice ovaries mimicking PRs and ovarian insufficiency, induced by chemotherapy, after BMDSC infusion. Furthermore, BMDSC treatment resulted in production of higher numbers of preovulatory follicles, metaphase II oocytes, 2-cell embryos, and healthy pups. Stem cells promoted ovarian vascularization and cell proliferation, along with reduced apoptosis. In xenografted human ovarian tissues from PRs, infusion of BMDSCs and their CD133+ fraction led to their engraftment close to follicles, resulting in promotion of follicular growth, increases in E2 secretion, and enhanced local vascularization.
Our results raised the possibility that promoting ovarian angiogenesis by BMDSC infusion could be an alternative approach to improve follicular development in women with impaired ovarian function.
NCT02240342.</description><subject>Animals</subject><subject>Bone Marrow Cells - physiology</subject><subject>Bone Marrow Transplantation - methods</subject><subject>Bone marrow–derived stem cell infusion</subject><subject>Female</subject><subject>follicle rescue</subject><subject>Humans</subject><subject>Infertility, Female - diagnosis</subject><subject>Infertility, Female - therapy</subject><subject>Mice</subject><subject>Mice, Inbred NOD</subject><subject>Mice, SCID</subject><subject>Ovarian Follicle - growth & development</subject><subject>ovarian niche regeneration</subject><subject>poor ovarian response</subject><subject>primary ovarian insufficiency</subject><subject>Stem Cell Transplantation - methods</subject><subject>Stem Cells - physiology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDFPwzAQhS0EoqXwF5BHloSzkzjJCBUFpEosILFZjnMBV0lc7KSo_x6XFhhZfIPfu3vvI4QyiBkwcb2KG3RD74fwxhxYEQOLAdIjMmVZJqJMZMkxmQKwLAJe8Ak5834FAILl_JRMeJnlIknZlLwuwgrTmmFLHXo9IlV9Te1GOaN62ti2NbpF-ubs5_BO1852djC2p9WWVrZH2ikXvmhI0lGNbUtN34w-KM7JSaNajxeHOSMvi7vn-UO0fLp_nN8sI53ydIiwyjXTpQBd1jqvEFXBNYAqU1bXoCueQ1KlyEsuAEVThmZVoYVq8rRJ64wnM3K13xuyfYzoB9kZv0uierSjlzs6QhSQlEFa7KXaWe8dNnLtTCiwlQzkjqtcyT-u304JTAauwXp5uDJWHda_xh-QQXC7F2DoujHopNcGe421cagHWVvz_5UvoQiQyw</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Herraiz, Sonia</creator><creator>Buigues, Anna</creator><creator>Díaz-García, César</creator><creator>Romeu, Mónica</creator><creator>Martínez, Susana</creator><creator>Gómez-Seguí, Inés</creator><creator>Simón, Carlos</creator><creator>Hsueh, Aaron J.</creator><creator>Pellicer, Antonio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0703-6922</orcidid></search><sort><creationdate>201805</creationdate><title>Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion</title><author>Herraiz, Sonia ; Buigues, Anna ; Díaz-García, César ; Romeu, Mónica ; Martínez, Susana ; Gómez-Seguí, Inés ; Simón, Carlos ; Hsueh, Aaron J. ; Pellicer, Antonio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-eb7c1c960c9dc7beea82c00a941dd0cb2703b4e29260e6f9565b8c6af74f4d523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Bone Marrow Cells - physiology</topic><topic>Bone Marrow Transplantation - methods</topic><topic>Bone marrow–derived stem cell infusion</topic><topic>Female</topic><topic>follicle rescue</topic><topic>Humans</topic><topic>Infertility, Female - diagnosis</topic><topic>Infertility, Female - therapy</topic><topic>Mice</topic><topic>Mice, Inbred NOD</topic><topic>Mice, SCID</topic><topic>Ovarian Follicle - growth & development</topic><topic>ovarian niche regeneration</topic><topic>poor ovarian response</topic><topic>primary ovarian insufficiency</topic><topic>Stem Cell Transplantation - methods</topic><topic>Stem Cells - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Herraiz, Sonia</creatorcontrib><creatorcontrib>Buigues, Anna</creatorcontrib><creatorcontrib>Díaz-García, César</creatorcontrib><creatorcontrib>Romeu, Mónica</creatorcontrib><creatorcontrib>Martínez, Susana</creatorcontrib><creatorcontrib>Gómez-Seguí, Inés</creatorcontrib><creatorcontrib>Simón, Carlos</creatorcontrib><creatorcontrib>Hsueh, Aaron J.</creatorcontrib><creatorcontrib>Pellicer, Antonio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Herraiz, Sonia</au><au>Buigues, Anna</au><au>Díaz-García, César</au><au>Romeu, Mónica</au><au>Martínez, Susana</au><au>Gómez-Seguí, Inés</au><au>Simón, Carlos</au><au>Hsueh, Aaron J.</au><au>Pellicer, Antonio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2018-05</date><risdate>2018</risdate><volume>109</volume><issue>5</issue><spage>908</spage><epage>918.e2</epage><pages>908-918.e2</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>To assess if infusion of human bone marrow–derived stem cells (BMDSCs) could promote follicle development in patients with impaired ovarian functions.
Experimental design.
University research laboratories.
Immunodeficient NOD/SCID female mice.
Human BMDSCs were injected into mice with chemotherapy-induced ovarian damage and into immunodeficient mice xenografted with human cortex from poor-responder patients (PRs).
Follicle development, ovulation, and offspring. Apoptosis, proliferation, and vascularization were evaluated in mouse and human ovarian stroma.
Fertility rescue and spontaneous pregnancies were achieved in mice ovaries mimicking PRs and ovarian insufficiency, induced by chemotherapy, after BMDSC infusion. Furthermore, BMDSC treatment resulted in production of higher numbers of preovulatory follicles, metaphase II oocytes, 2-cell embryos, and healthy pups. Stem cells promoted ovarian vascularization and cell proliferation, along with reduced apoptosis. In xenografted human ovarian tissues from PRs, infusion of BMDSCs and their CD133+ fraction led to their engraftment close to follicles, resulting in promotion of follicular growth, increases in E2 secretion, and enhanced local vascularization.
Our results raised the possibility that promoting ovarian angiogenesis by BMDSC infusion could be an alternative approach to improve follicular development in women with impaired ovarian function.
NCT02240342.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29576341</pmid><doi>10.1016/j.fertnstert.2018.01.004</doi><orcidid>https://orcid.org/0000-0003-0703-6922</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Animals Bone Marrow Cells - physiology Bone Marrow Transplantation - methods Bone marrow–derived stem cell infusion Female follicle rescue Humans Infertility, Female - diagnosis Infertility, Female - therapy Mice Mice, Inbred NOD Mice, SCID Ovarian Follicle - growth & development ovarian niche regeneration poor ovarian response primary ovarian insufficiency Stem Cell Transplantation - methods Stem Cells - physiology |
| title | Fertility rescue and ovarian follicle growth promotion by bone marrow stem cell infusion |
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