Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation

Salvianolic acid A (SAA) is a water-soluble component from the root of Salvia Miltiorrhiza Bge, a traditional Chinese medicine, which has been used for the treatment of cerebrovascular diseases for centuries. The present study aimed to determine the brain protective effects of SAA against cerebral i...

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Veröffentlicht in:	Chinese journal of natural medicines 2018-03, Vol.16 (3), p.184-193
Hauptverfasser:	ZHANG, Wen, SONG, Jun-Ke, ZHANG, Xue, ZHOU, Qi-Meng, HE, Guo-Rong, XU, Xiao-Na, Rong, Yan, ZHOU, Wen-Xia, DU, Guan-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - administration & dosage Blood brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - enzymology Blood-Brain Barrier - immunology Brain Brain Ischemia - drug therapy Brain Ischemia - enzymology Brain Ischemia - genetics Caffeic Acids - administration & dosage Drugs, Chinese Herbal - administration & dosage Humans Ischemia Lactates - administration & dosage Male Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism MCAO MMP-9 NF-κB Rats Rats, Sprague-Dawley Reperfusion Injury - enzymology Reperfusion Injury - genetics Reperfusion Injury - immunology Reperfusion Injury - prevention & control Salvia miltiorrhiza - chemistry Salvianolic acid A Tissue Inhibitor of Metalloproteinase-1 - genetics Tissue Inhibitor of Metalloproteinase-1 - metabolism Transcription Factor RelA - genetics Transcription Factor RelA - immunology
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