Mitochondrial inhibitory factor protein 1 attenuates coupling factor 6‐induced aging signal

Coupling factor 6 (CF6) forces a counter‐clockwise rotation of plasma membrane F1Fo complex, resulting in proton import and accelerated aging. Inhibitory factor peptide 1 (IF1) suppresses a unidirectional counter‐clockwise rotation of F1Fo complex without affecting ATP synthesis. We tested the hypot...

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Veröffentlicht in:	Journal of cellular biochemistry 2018-07, Vol.119 (7), p.6194-6203
Hauptverfasser:	Osanai, Tomohiro, Tanaka, Makoto, Mikami, Kasumi, Kitajima, Maiko, Magota, Koji, Tomita, Hirofumi, Okumura, Ken
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging aging hallmarks Animals ATPase Inhibitory Protein coupling factor 6 ecto‐F1Fo complex Genomic Instability inhibitory peptide 1 intracellular acidosis Mice Mice, Inbred C57BL Mice, Transgenic Mitochondria - metabolism Mitochondrial Proton-Translocating ATPases - genetics Mitochondrial Proton-Translocating ATPases - metabolism Oxidative Phosphorylation Coupling Factors - genetics Oxidative Phosphorylation Coupling Factors - metabolism Proteins - genetics Proteins - metabolism
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