Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats
The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) in preventing joint stiffness. Unilateral knee joints were immobilized in two groups of rats (n = 6/period/group). Under general anesthesia, the immobilized knee joints were exposed to LIPUS for 20 min/d,...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2018-06, Vol.44 (6), p.1244-1256 |
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| creator | Itaya, Nobuyuki Yabe, Yutake Hagiwara, Yoshihiro Kanazawa, Kenji Koide, Masashi Sekiguchi, Takuya Yoshida, Shinichirou Sogi, Yasuhito Yano, Toshihisa Tsuchiya, Masahiro Saijo, Yoshihumi Itoi, Eiji |
| description | The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) in preventing joint stiffness. Unilateral knee joints were immobilized in two groups of rats (n = 6/period/group). Under general anesthesia, the immobilized knee joints were exposed to LIPUS for 20 min/d, 5 d/wk, using an existing LIPUS device (LIPUS group, 1.5-MHz frequency, 1.0-kHz repetition cycle, 200-µs burst width and 30-mW/cm2 power output) until endpoints (2, 4 or 6 wk). In the control group, general anesthesia alone was administered in the same manner as in the other group. The variables compared between the groups included joint angles; histologic, histomorphometric and immunohistochemical analyses; quantitative reverse transcription polymerase chain reactions; and tissue elasticity. LIPUS had a preventive effect on joint stiffness, resulting in decreased adhesion, fibrosis and inflammation and hypoxic response after joint immobilization. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2018.02.002 |
| format | Article |
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Unilateral knee joints were immobilized in two groups of rats (n = 6/period/group). Under general anesthesia, the immobilized knee joints were exposed to LIPUS for 20 min/d, 5 d/wk, using an existing LIPUS device (LIPUS group, 1.5-MHz frequency, 1.0-kHz repetition cycle, 200-µs burst width and 30-mW/cm2 power output) until endpoints (2, 4 or 6 wk). In the control group, general anesthesia alone was administered in the same manner as in the other group. The variables compared between the groups included joint angles; histologic, histomorphometric and immunohistochemical analyses; quantitative reverse transcription polymerase chain reactions; and tissue elasticity. LIPUS had a preventive effect on joint stiffness, resulting in decreased adhesion, fibrosis and inflammation and hypoxic response after joint immobilization.</description><identifier>ISSN: 0301-5629</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2018.02.002</identifier><identifier>PMID: 29573888</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Adhesion ; Animals ; Disease Models, Animal ; Elasticity ; Fibrosis ; Hypoxia ; Inflammation ; Joint contracture ; Joint Diseases - prevention & control ; Joint immobilization ; Joint stiffness ; Knee Joint ; LIPUS ; Low-intensity pulsed ultrasound ; Male ; Rats ; Rats, Sprague-Dawley ; Ultrasonic Therapy - methods ; Ultrasonic Waves</subject><ispartof>Ultrasound in medicine & biology, 2018-06, Vol.44 (6), p.1244-1256</ispartof><rights>2018 World Federation for Ultrasound in Medicine and Biology</rights><rights>Copyright © 2018 World Federation for Ultrasound in Medicine and Biology. 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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-e9cedeacd4467a6296c43f3f48afed78ed0a1b5ba61a4cf3a2819a46f05a97f53</citedby><cites>FETCH-LOGICAL-c446t-e9cedeacd4467a6296c43f3f48afed78ed0a1b5ba61a4cf3a2819a46f05a97f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2018.02.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27928,27929,45999</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29573888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Itaya, Nobuyuki</creatorcontrib><creatorcontrib>Yabe, Yutake</creatorcontrib><creatorcontrib>Hagiwara, Yoshihiro</creatorcontrib><creatorcontrib>Kanazawa, Kenji</creatorcontrib><creatorcontrib>Koide, Masashi</creatorcontrib><creatorcontrib>Sekiguchi, Takuya</creatorcontrib><creatorcontrib>Yoshida, Shinichirou</creatorcontrib><creatorcontrib>Sogi, Yasuhito</creatorcontrib><creatorcontrib>Yano, Toshihisa</creatorcontrib><creatorcontrib>Tsuchiya, Masahiro</creatorcontrib><creatorcontrib>Saijo, Yoshihumi</creatorcontrib><creatorcontrib>Itoi, Eiji</creatorcontrib><title>Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description>The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) in preventing joint stiffness. Unilateral knee joints were immobilized in two groups of rats (n = 6/period/group). Under general anesthesia, the immobilized knee joints were exposed to LIPUS for 20 min/d, 5 d/wk, using an existing LIPUS device (LIPUS group, 1.5-MHz frequency, 1.0-kHz repetition cycle, 200-µs burst width and 30-mW/cm2 power output) until endpoints (2, 4 or 6 wk). In the control group, general anesthesia alone was administered in the same manner as in the other group. The variables compared between the groups included joint angles; histologic, histomorphometric and immunohistochemical analyses; quantitative reverse transcription polymerase chain reactions; and tissue elasticity. LIPUS had a preventive effect on joint stiffness, resulting in decreased adhesion, fibrosis and inflammation and hypoxic response after joint immobilization.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Elasticity</subject><subject>Fibrosis</subject><subject>Hypoxia</subject><subject>Inflammation</subject><subject>Joint contracture</subject><subject>Joint Diseases - prevention & control</subject><subject>Joint immobilization</subject><subject>Joint stiffness</subject><subject>Knee Joint</subject><subject>LIPUS</subject><subject>Low-intensity pulsed ultrasound</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Ultrasonic Therapy - methods</subject><subject>Ultrasonic Waves</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1P3DAQhq2Kqizb_gVkceKSYOfDSbghPsrCVkVtkXqzHHuMvCQ22A4V_fV42aXi2NNoNO8778yD0AElOSWUHa3yaYhehBFUb1xeENrmpMgJKT6gGW2bLis6-nsHzUhJaFazottFeyGsCCENK5tPaLfo6qZs23aG7s-1BhkDdhov3Z9sYSPYYOIzvpmGAArfvka5ySqsncc3Hp7ARmPv8JUzNuKf0WhtIQRsLF6Mo-vNYP4m47UFwN-cgmE9-SFi-Iw-apGWftnWObq9OP91epktv39dnJ4sM1lVLGbQSVAgpEpdI9L1TFalLnXVCg2qaUERQfu6F4yKSupSFC3tRMU0qUXX6Lqco8PN3gfvHicIkY8mSBgGYcFNga-BMVbXNUnS441UeheCB80fvBmFf-aU8DVsvuLvYb96OSl4gp3M-9ucqU_jf9Y3uklwthFA-vbJgOdBGrDpPeMTdK6c-Z-cF5ZTmdk</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Itaya, Nobuyuki</creator><creator>Yabe, Yutake</creator><creator>Hagiwara, Yoshihiro</creator><creator>Kanazawa, Kenji</creator><creator>Koide, Masashi</creator><creator>Sekiguchi, Takuya</creator><creator>Yoshida, Shinichirou</creator><creator>Sogi, Yasuhito</creator><creator>Yano, Toshihisa</creator><creator>Tsuchiya, Masahiro</creator><creator>Saijo, Yoshihumi</creator><creator>Itoi, Eiji</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats</title><author>Itaya, Nobuyuki ; Yabe, Yutake ; Hagiwara, Yoshihiro ; Kanazawa, Kenji ; Koide, Masashi ; Sekiguchi, Takuya ; Yoshida, Shinichirou ; Sogi, Yasuhito ; Yano, Toshihisa ; Tsuchiya, Masahiro ; Saijo, Yoshihumi ; Itoi, Eiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-e9cedeacd4467a6296c43f3f48afed78ed0a1b5ba61a4cf3a2819a46f05a97f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Elasticity</topic><topic>Fibrosis</topic><topic>Hypoxia</topic><topic>Inflammation</topic><topic>Joint contracture</topic><topic>Joint Diseases - prevention & control</topic><topic>Joint immobilization</topic><topic>Joint stiffness</topic><topic>Knee Joint</topic><topic>LIPUS</topic><topic>Low-intensity pulsed ultrasound</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Ultrasonic Therapy - methods</topic><topic>Ultrasonic Waves</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Itaya, Nobuyuki</creatorcontrib><creatorcontrib>Yabe, Yutake</creatorcontrib><creatorcontrib>Hagiwara, Yoshihiro</creatorcontrib><creatorcontrib>Kanazawa, Kenji</creatorcontrib><creatorcontrib>Koide, Masashi</creatorcontrib><creatorcontrib>Sekiguchi, Takuya</creatorcontrib><creatorcontrib>Yoshida, Shinichirou</creatorcontrib><creatorcontrib>Sogi, Yasuhito</creatorcontrib><creatorcontrib>Yano, Toshihisa</creatorcontrib><creatorcontrib>Tsuchiya, Masahiro</creatorcontrib><creatorcontrib>Saijo, Yoshihumi</creatorcontrib><creatorcontrib>Itoi, Eiji</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Itaya, Nobuyuki</au><au>Yabe, Yutake</au><au>Hagiwara, Yoshihiro</au><au>Kanazawa, Kenji</au><au>Koide, Masashi</au><au>Sekiguchi, Takuya</au><au>Yoshida, Shinichirou</au><au>Sogi, Yasuhito</au><au>Yano, Toshihisa</au><au>Tsuchiya, Masahiro</au><au>Saijo, Yoshihumi</au><au>Itoi, Eiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2018-06</date><risdate>2018</risdate><volume>44</volume><issue>6</issue><spage>1244</spage><epage>1256</epage><pages>1244-1256</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>The purpose of this study was to examine the effect of low-intensity pulsed ultrasound (LIPUS) in preventing joint stiffness. 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| subjects | Adhesion Animals Disease Models, Animal Elasticity Fibrosis Hypoxia Inflammation Joint contracture Joint Diseases - prevention & control Joint immobilization Joint stiffness Knee Joint LIPUS Low-intensity pulsed ultrasound Male Rats Rats, Sprague-Dawley Ultrasonic Therapy - methods Ultrasonic Waves |
| title | Effects of Low-Intensity Pulsed Ultrasound for Preventing Joint Stiffness in Immobilized Knee Model in Rats |
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