High frequency of the PNPLA3 rs738409 [G] single‐nucleotide polymorphism in Hmong individuals as a potential basis for a predisposition to chronic liver disease

BACKGROUND An exploratory study was performed to determine the prevalence of the patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) rs78409 [G] allele among the Hmong as a risk factor for nonalcoholic fatty liver disease (NAFLD). NAFLD/nonalcoholic steatohepatitis is the world's mo...

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Veröffentlicht in:	Cancer 2018-04, Vol.124 (S7), p.1583-1589
Hauptverfasser:	Tepper, Clifford G., Dang, Julie H. T., Stewart, Susan L., Fang, Dao M., Wong, Kimberly A., Liu, Stephenie Y., Davis, Ryan R., Dao, Doan Y., Gregg, Jeffrey P., Török, Natalie J., Chen, Moon S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Alleles Asian Americans - genetics California - epidemiology Cancer carrier rate Chronic Disease Cirrhosis Confidence intervals Deoxyribonucleic acid DNA Etiology Fatty liver Female Follow-Up Studies Genetic Predisposition to Disease Genomes Genotype Genotyping Health risks Hepatitis Hepatocellular carcinoma High frequencies Hmong Hmong people Humans Incidence Lipase - genetics Liver Liver cancer Liver cirrhosis Liver Cirrhosis - epidemiology Liver Cirrhosis - genetics Liver diseases Male Membrane Proteins - genetics Metabolic syndrome Middle Aged nonalcoholic steatohepatitis (NASH) Oncology patatin‐like phospholipase domain‐containing protein 3 (PNPLA3) rs738409 Phospholipase Polymerase chain reaction Polymorphism Polymorphism, Single Nucleotide Prognosis Risk analysis Risk factors Single-nucleotide polymorphism Young Adult
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