Matrix‐assisted laser desorption/ionization imaging mass spectrometry of intraperitoneally injected danegaptide (ZP1609) for treatment of stroke‐reperfusion injury in mice

Rationale This work focuses on direct matrix‐assisted laser desorption/ionization imaging mass spectrometry (MALDI‐IMS) detection of intraperitoneally (IP)‐injected dipeptide ZP1609 in mouse brain tissue. Direct analysis of drug detection in intact tissue sections provides distribution information t...

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Veröffentlicht in:	Rapid communications in mass spectrometry 2018-06, Vol.32 (12), p.951-958
Hauptverfasser:	Wang, Jasmine S.H., Freitas‐Andrade, Moises, Bechberger, John F., Naus, Christian C., Yeung, Ken K.‐C., Whitehead, Shawn N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidification Adducts Animals Barriers Biological effects Blood Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Brain - drug effects Brain - metabolism Data acquisition Desorption Dipeptides - administration & dosage Dipeptides - pharmacokinetics Dipeptides - therapeutic use Drug delivery systems Drug Monitoring - methods Image acquisition Injections, Intraperitoneal Ionization Ions Mass spectrometry Mice Mice, Inbred C57BL Peptides Protective Agents - administration & dosage Protective Agents - pharmacokinetics Protective Agents - therapeutic use Reperfusion Injury - drug therapy Scientific imaging Sensitivity enhancement Signal detection Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Spectroscopy Stroke - drug therapy Target detection Transport
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