Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New York

Background p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function. Objectives We evaluated whether three well-characterized TP53 variants—Ex4 + 119 C > G (rs#1042522, Arg72Pro), IVS...

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Veröffentlicht in:	Breast cancer research and treatment 2008-03, Vol.108 (1), p.93-99
Hauptverfasser:	Gaudet, Mia M., Gammon, Marilie D., Bensen, Jeannette T., Sagiv, Sharon K., Shantakumar, Sumitra, Teitelbaum, Susan L., Eng, Sybil M., Neugut, Alfred I., Santella, Regina M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Breast cancer Breast Neoplasms - genetics Cancer research DNA Adducts - blood Epidemiology Female Gene expression Genetic Predisposition to Disease Genotype Gynecology. Andrology. Obstetrics Haplotypes Human exposure Humans Mammary gland diseases Medical sciences Medicine Medicine & Public Health Middle Aged New York Oncology Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - adverse effects Polycyclic Aromatic Hydrocarbons - blood Polymerase Chain Reaction Risk Factors Smoking Smoking - adverse effects Tobacco, tobacco smoking Toxicology Tumor Suppressor Protein p53 - genetics Tumors
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