Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow
Objective Evaluate, in vivo, the biocompatibility via subcutaneous inflammatory tissue response and mineralization ability of the new MTA Flow compared to MTA Angelus and ProRoot MTA. Materials and methods Forty male Wistar rats were assigned and received subcutaneous polyethylene tube implants cont...
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| Veröffentlicht in: | Clinical oral investigations 2019-01, Vol.23 (1), p.169-177 |
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| creator | Bueno, Carlos Roberto Emerenciano Vasques, Ana Maria Veiga Cury, Marina Tolomei Sandoval Sivieri-Araújo, Gustavo Jacinto, Rogério Castilho Gomes-Filho, João Eduardo Cintra, Luciano Tavares Angelo Dezan-Júnior, Eloi |
| description | Objective
Evaluate, in vivo, the biocompatibility via subcutaneous inflammatory tissue response and mineralization ability of the new MTA Flow compared to MTA Angelus and ProRoot MTA.
Materials and methods
Forty male Wistar rats were assigned and received subcutaneous polyethylene tube implants containing the test materials and a control group with empty tube (
n
= 10 animals/group). After days 7, 15, 30, and 60, the animals were euthanized and the polyethylene tubes were removed with the surrounding tissues. Inflammatory infiltrate and thickness of the fibrous capsule were histologically evaluated. Mineralization was analyzed by Von Kossa staining and under polarized light. Data were analyzed via Kruskal-Wallis and Dunn’s test with a significance level of 5%.
Results
MTA Angelus induced the mildest reaction after 7 (
P
> .05) and 15 days (
P
.05). No difference was observed after days 30 or 60 (
P
> .05). Von Kossa staining and birefringent structures were positive to all materials.
Conclusions
At the end of the experiment, the novel MTA Flow showed biocompatibility and induced biomineralization in all time periods.
Clinical relevance
The final consistence obtained in MTA Flow may facilitate several procedures, indicating that the MTA Flow has a promising application in endodontics. |
| doi_str_mv | 10.1007/s00784-018-2423-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2018033176</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2018033176</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-d21243334eac77d32021a9cb5cfa680ad283f4b21d82b0009a27e250101402413</originalsourceid><addsrcrecordid>eNp1kE9LwzAYh4Mobk4_gBcpePFSffMma9qjDv-B4GWeQ9qmI6NtZtKi89Ob2qkgeEkCv-f9JXkIOaVwSQHElQ9LymOgaYwcWQx7ZEo5S2ImBN3_OmOcZCmdkCPv1wCUJ4Idkglmc4FJKqZkeWNsYZuN6kxuatNtI9WWUW5sY1rtVG0-QmLbSHmvvW9020W2inZh1Dlj302pI7VaOb1SnY6q2r4dk4NK1V6f7PYZebm7XS4e4qfn-8fF9VNc8JR2cYkUOWOMa1UIUTIEpCor8nlRqSQFVWLKKp4jLVPMASBTKDTOgYZ_AHLKZuRi7N04-9pr38nG-ELXtWq17b3EYAYYoyIJ6PkfdG1714bXDZRgiEkGgaIjVTjrvdOV3DjTKLeVFOSgXI7KZSiWg3I5zJztmvu80eXPxLfjAOAI-BC1K-1-r_6_9RPoJ4sZ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2017322690</pqid></control><display><type>article</type><title>Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow</title><source>SpringerLink Journals - AutoHoldings</source><creator>Bueno, Carlos Roberto Emerenciano ; Vasques, Ana Maria Veiga ; Cury, Marina Tolomei Sandoval ; Sivieri-Araújo, Gustavo ; Jacinto, Rogério Castilho ; Gomes-Filho, João Eduardo ; Cintra, Luciano Tavares Angelo ; Dezan-Júnior, Eloi</creator><creatorcontrib>Bueno, Carlos Roberto Emerenciano ; Vasques, Ana Maria Veiga ; Cury, Marina Tolomei Sandoval ; Sivieri-Araújo, Gustavo ; Jacinto, Rogério Castilho ; Gomes-Filho, João Eduardo ; Cintra, Luciano Tavares Angelo ; Dezan-Júnior, Eloi</creatorcontrib><description>Objective
Evaluate, in vivo, the biocompatibility via subcutaneous inflammatory tissue response and mineralization ability of the new MTA Flow compared to MTA Angelus and ProRoot MTA.
Materials and methods
Forty male Wistar rats were assigned and received subcutaneous polyethylene tube implants containing the test materials and a control group with empty tube (
n
= 10 animals/group). After days 7, 15, 30, and 60, the animals were euthanized and the polyethylene tubes were removed with the surrounding tissues. Inflammatory infiltrate and thickness of the fibrous capsule were histologically evaluated. Mineralization was analyzed by Von Kossa staining and under polarized light. Data were analyzed via Kruskal-Wallis and Dunn’s test with a significance level of 5%.
Results
MTA Angelus induced the mildest reaction after 7 (
P
> .05) and 15 days (
P
< .05) followed by MTA Flow, both cements achieving mild inflammatory reaction after 15 days. ProRoot MTA induced a severe inflammation on day 7 and was reducing after day 15 (
P
> .05). No difference was observed after days 30 or 60 (
P
> .05). Von Kossa staining and birefringent structures were positive to all materials.
Conclusions
At the end of the experiment, the novel MTA Flow showed biocompatibility and induced biomineralization in all time periods.
Clinical relevance
The final consistence obtained in MTA Flow may facilitate several procedures, indicating that the MTA Flow has a promising application in endodontics.</description><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-018-2423-0</identifier><identifier>PMID: 29572687</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biocompatibility ; Data processing ; Dentistry ; Endodontics ; Inflammation ; Medicine ; Mineralization ; Original Article ; Polarized light ; Polyethylene</subject><ispartof>Clinical oral investigations, 2019-01, Vol.23 (1), p.169-177</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Clinical Oral Investigations is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-d21243334eac77d32021a9cb5cfa680ad283f4b21d82b0009a27e250101402413</citedby><cites>FETCH-LOGICAL-c481t-d21243334eac77d32021a9cb5cfa680ad283f4b21d82b0009a27e250101402413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00784-018-2423-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00784-018-2423-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29572687$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bueno, Carlos Roberto Emerenciano</creatorcontrib><creatorcontrib>Vasques, Ana Maria Veiga</creatorcontrib><creatorcontrib>Cury, Marina Tolomei Sandoval</creatorcontrib><creatorcontrib>Sivieri-Araújo, Gustavo</creatorcontrib><creatorcontrib>Jacinto, Rogério Castilho</creatorcontrib><creatorcontrib>Gomes-Filho, João Eduardo</creatorcontrib><creatorcontrib>Cintra, Luciano Tavares Angelo</creatorcontrib><creatorcontrib>Dezan-Júnior, Eloi</creatorcontrib><title>Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Objective
Evaluate, in vivo, the biocompatibility via subcutaneous inflammatory tissue response and mineralization ability of the new MTA Flow compared to MTA Angelus and ProRoot MTA.
Materials and methods
Forty male Wistar rats were assigned and received subcutaneous polyethylene tube implants containing the test materials and a control group with empty tube (
n
= 10 animals/group). After days 7, 15, 30, and 60, the animals were euthanized and the polyethylene tubes were removed with the surrounding tissues. Inflammatory infiltrate and thickness of the fibrous capsule were histologically evaluated. Mineralization was analyzed by Von Kossa staining and under polarized light. Data were analyzed via Kruskal-Wallis and Dunn’s test with a significance level of 5%.
Results
MTA Angelus induced the mildest reaction after 7 (
P
> .05) and 15 days (
P
< .05) followed by MTA Flow, both cements achieving mild inflammatory reaction after 15 days. ProRoot MTA induced a severe inflammation on day 7 and was reducing after day 15 (
P
> .05). No difference was observed after days 30 or 60 (
P
> .05). Von Kossa staining and birefringent structures were positive to all materials.
Conclusions
At the end of the experiment, the novel MTA Flow showed biocompatibility and induced biomineralization in all time periods.
Clinical relevance
The final consistence obtained in MTA Flow may facilitate several procedures, indicating that the MTA Flow has a promising application in endodontics.</description><subject>Biocompatibility</subject><subject>Data processing</subject><subject>Dentistry</subject><subject>Endodontics</subject><subject>Inflammation</subject><subject>Medicine</subject><subject>Mineralization</subject><subject>Original Article</subject><subject>Polarized light</subject><subject>Polyethylene</subject><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kE9LwzAYh4Mobk4_gBcpePFSffMma9qjDv-B4GWeQ9qmI6NtZtKi89Ob2qkgeEkCv-f9JXkIOaVwSQHElQ9LymOgaYwcWQx7ZEo5S2ImBN3_OmOcZCmdkCPv1wCUJ4Idkglmc4FJKqZkeWNsYZuN6kxuatNtI9WWUW5sY1rtVG0-QmLbSHmvvW9020W2inZh1Dlj302pI7VaOb1SnY6q2r4dk4NK1V6f7PYZebm7XS4e4qfn-8fF9VNc8JR2cYkUOWOMa1UIUTIEpCor8nlRqSQFVWLKKp4jLVPMASBTKDTOgYZ_AHLKZuRi7N04-9pr38nG-ELXtWq17b3EYAYYoyIJ6PkfdG1714bXDZRgiEkGgaIjVTjrvdOV3DjTKLeVFOSgXI7KZSiWg3I5zJztmvu80eXPxLfjAOAI-BC1K-1-r_6_9RPoJ4sZ</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Bueno, Carlos Roberto Emerenciano</creator><creator>Vasques, Ana Maria Veiga</creator><creator>Cury, Marina Tolomei Sandoval</creator><creator>Sivieri-Araújo, Gustavo</creator><creator>Jacinto, Rogério Castilho</creator><creator>Gomes-Filho, João Eduardo</creator><creator>Cintra, Luciano Tavares Angelo</creator><creator>Dezan-Júnior, Eloi</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20190101</creationdate><title>Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow</title><author>Bueno, Carlos Roberto Emerenciano ; Vasques, Ana Maria Veiga ; Cury, Marina Tolomei Sandoval ; Sivieri-Araújo, Gustavo ; Jacinto, Rogério Castilho ; Gomes-Filho, João Eduardo ; Cintra, Luciano Tavares Angelo ; Dezan-Júnior, Eloi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-d21243334eac77d32021a9cb5cfa680ad283f4b21d82b0009a27e250101402413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biocompatibility</topic><topic>Data processing</topic><topic>Dentistry</topic><topic>Endodontics</topic><topic>Inflammation</topic><topic>Medicine</topic><topic>Mineralization</topic><topic>Original Article</topic><topic>Polarized light</topic><topic>Polyethylene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bueno, Carlos Roberto Emerenciano</creatorcontrib><creatorcontrib>Vasques, Ana Maria Veiga</creatorcontrib><creatorcontrib>Cury, Marina Tolomei Sandoval</creatorcontrib><creatorcontrib>Sivieri-Araújo, Gustavo</creatorcontrib><creatorcontrib>Jacinto, Rogério Castilho</creatorcontrib><creatorcontrib>Gomes-Filho, João Eduardo</creatorcontrib><creatorcontrib>Cintra, Luciano Tavares Angelo</creatorcontrib><creatorcontrib>Dezan-Júnior, Eloi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bueno, Carlos Roberto Emerenciano</au><au>Vasques, Ana Maria Veiga</au><au>Cury, Marina Tolomei Sandoval</au><au>Sivieri-Araújo, Gustavo</au><au>Jacinto, Rogério Castilho</au><au>Gomes-Filho, João Eduardo</au><au>Cintra, Luciano Tavares Angelo</au><au>Dezan-Júnior, Eloi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>23</volume><issue>1</issue><spage>169</spage><epage>177</epage><pages>169-177</pages><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Objective
Evaluate, in vivo, the biocompatibility via subcutaneous inflammatory tissue response and mineralization ability of the new MTA Flow compared to MTA Angelus and ProRoot MTA.
Materials and methods
Forty male Wistar rats were assigned and received subcutaneous polyethylene tube implants containing the test materials and a control group with empty tube (
n
= 10 animals/group). After days 7, 15, 30, and 60, the animals were euthanized and the polyethylene tubes were removed with the surrounding tissues. Inflammatory infiltrate and thickness of the fibrous capsule were histologically evaluated. Mineralization was analyzed by Von Kossa staining and under polarized light. Data were analyzed via Kruskal-Wallis and Dunn’s test with a significance level of 5%.
Results
MTA Angelus induced the mildest reaction after 7 (
P
> .05) and 15 days (
P
< .05) followed by MTA Flow, both cements achieving mild inflammatory reaction after 15 days. ProRoot MTA induced a severe inflammation on day 7 and was reducing after day 15 (
P
> .05). No difference was observed after days 30 or 60 (
P
> .05). Von Kossa staining and birefringent structures were positive to all materials.
Conclusions
At the end of the experiment, the novel MTA Flow showed biocompatibility and induced biomineralization in all time periods.
Clinical relevance
The final consistence obtained in MTA Flow may facilitate several procedures, indicating that the MTA Flow has a promising application in endodontics.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29572687</pmid><doi>10.1007/s00784-018-2423-0</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1432-6981 |
| ispartof | Clinical oral investigations, 2019-01, Vol.23 (1), p.169-177 |
| issn | 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2018033176 |
| source | SpringerLink Journals - AutoHoldings |
| subjects | Biocompatibility Data processing Dentistry Endodontics Inflammation Medicine Mineralization Original Article Polarized light Polyethylene |
| title | Biocompatibility and biomineralization assessment of mineral trioxide aggregate flow |
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