The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma
•Low proportion of cancer cells in the invasive area had better prognosis.•This was associated with the greater proportion of VVG-positive elastic fibers.•The character of the invasive area could be a useful histologic prognostic parameter. This study evaluated whether the proportion of cancer cells...
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| Veröffentlicht in: | Lung cancer (Amsterdam, Netherlands) Netherlands), 2018-04, Vol.118, p.30-35 |
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| creator | Ichikawa, Tomohiro Aokage, Keiju Sugano, Masato Miyoshi, Tomohiro Kojima, Motohiro Fujii, Satoshi Kuwata, Takeshi Ochiai, Atsushi Suzuki, Kenji Tsuboi, Masahiro Ishii, Genichiro |
| description | •Low proportion of cancer cells in the invasive area had better prognosis.•This was associated with the greater proportion of VVG-positive elastic fibers.•The character of the invasive area could be a useful histologic prognostic parameter.
This study evaluated whether the proportion of cancer cells to non-cancerous stroma within the invasive area is associated with the prognosis of patients with lung adenocarcinoma.
A total of 127 patients with lung adenocarcinomas with tumors larger than 3 cm in total size were enrolled in this study. We classified the tumors according to the ratio of area occupied by cancer cells within the invasive area (Type A: more than 50% of the invasive area, Type B: 10–50%, and Type C: less than 10%) and analyzed the clinicopathological differences between Types A, B, and C.
The invasive size of Type A tumors (n = 35) was significantly larger than those of the other two tumor types; however, there was no significant difference in the invasive size between Types B (n = 65) and C (n = 25) tumors. The recurrence-free survival time of patients with Type C tumors was significantly longer than those of patients with Type A and B (P |
| doi_str_mv | 10.1016/j.lungcan.2018.01.023 |
| format | Article |
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This study evaluated whether the proportion of cancer cells to non-cancerous stroma within the invasive area is associated with the prognosis of patients with lung adenocarcinoma.
A total of 127 patients with lung adenocarcinomas with tumors larger than 3 cm in total size were enrolled in this study. We classified the tumors according to the ratio of area occupied by cancer cells within the invasive area (Type A: more than 50% of the invasive area, Type B: 10–50%, and Type C: less than 10%) and analyzed the clinicopathological differences between Types A, B, and C.
The invasive size of Type A tumors (n = 35) was significantly larger than those of the other two tumor types; however, there was no significant difference in the invasive size between Types B (n = 65) and C (n = 25) tumors. The recurrence-free survival time of patients with Type C tumors was significantly longer than those of patients with Type A and B (P < .001) tumors. Multivariate analysis revealed that Type C tumor was an independent favorable prognostic factor (P = .037) but that invasive size was not. The invasive area of Type C tumor was composed of a significantly higher proportion of collapsed elastic fibers than the invasive areas of Type A and B tumors (P < .001).
A lower cancer cell to stroma ratio within the invasive area could be a significant prognostic factor in lung adenocarcinoma, suggesting that not only the invasive size but also the invasive character might be an important histologic prognostic parameter.</description><identifier>ISSN: 0169-5002</identifier><identifier>EISSN: 1872-8332</identifier><identifier>DOI: 10.1016/j.lungcan.2018.01.023</identifier><identifier>PMID: 29571999</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Adult ; Aged ; Aged, 80 and over ; Cancer cell ratio ; Elastic fiber ; Elastic Tissue - pathology ; Female ; Humans ; Invasive area ; Lung adenocarcinoma ; Lung Neoplasms - diagnosis ; Lung Neoplasms - mortality ; Lung Neoplasms - pathology ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Paraffin Embedding ; Predictive Value of Tests ; Prognosis ; Stromal Cells - pathology ; Survival Analysis ; Tumor Microenvironment</subject><ispartof>Lung cancer (Amsterdam, Netherlands), 2018-04, Vol.118, p.30-35</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-8dd96943c2a933a92ca4fdd4a5cd8d35136aa8bb2bec3344bf51e1bcc4b9c82c3</citedby><cites>FETCH-LOGICAL-c431t-8dd96943c2a933a92ca4fdd4a5cd8d35136aa8bb2bec3344bf51e1bcc4b9c82c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.lungcan.2018.01.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29571999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ichikawa, Tomohiro</creatorcontrib><creatorcontrib>Aokage, Keiju</creatorcontrib><creatorcontrib>Sugano, Masato</creatorcontrib><creatorcontrib>Miyoshi, Tomohiro</creatorcontrib><creatorcontrib>Kojima, Motohiro</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Kuwata, Takeshi</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tsuboi, Masahiro</creatorcontrib><creatorcontrib>Ishii, Genichiro</creatorcontrib><title>The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma</title><title>Lung cancer (Amsterdam, Netherlands)</title><addtitle>Lung Cancer</addtitle><description>•Low proportion of cancer cells in the invasive area had better prognosis.•This was associated with the greater proportion of VVG-positive elastic fibers.•The character of the invasive area could be a useful histologic prognostic parameter.
This study evaluated whether the proportion of cancer cells to non-cancerous stroma within the invasive area is associated with the prognosis of patients with lung adenocarcinoma.
A total of 127 patients with lung adenocarcinomas with tumors larger than 3 cm in total size were enrolled in this study. We classified the tumors according to the ratio of area occupied by cancer cells within the invasive area (Type A: more than 50% of the invasive area, Type B: 10–50%, and Type C: less than 10%) and analyzed the clinicopathological differences between Types A, B, and C.
The invasive size of Type A tumors (n = 35) was significantly larger than those of the other two tumor types; however, there was no significant difference in the invasive size between Types B (n = 65) and C (n = 25) tumors. The recurrence-free survival time of patients with Type C tumors was significantly longer than those of patients with Type A and B (P < .001) tumors. Multivariate analysis revealed that Type C tumor was an independent favorable prognostic factor (P = .037) but that invasive size was not. The invasive area of Type C tumor was composed of a significantly higher proportion of collapsed elastic fibers than the invasive areas of Type A and B tumors (P < .001).
A lower cancer cell to stroma ratio within the invasive area could be a significant prognostic factor in lung adenocarcinoma, suggesting that not only the invasive size but also the invasive character might be an important histologic prognostic parameter.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer cell ratio</subject><subject>Elastic fiber</subject><subject>Elastic Tissue - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Invasive area</subject><subject>Lung adenocarcinoma</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Paraffin Embedding</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Stromal Cells - pathology</subject><subject>Survival Analysis</subject><subject>Tumor Microenvironment</subject><issn>0169-5002</issn><issn>1872-8332</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EotvCTwD5yCWpP5Ld-IRQVaBSJS7lbE3Gk12vkrjY3qX99zjswrUn-_C878w8jH2QopZCrq_39XiYtwhzrYTsaiFrofQrtpLdRlWd1uo1WxXOVK0Q6oJdprQXQm6kMG_ZhTLtRhpjVuzpYUc8QvaBh4GXOqTIkcYx8Rx4yjFMwH_7vPMzzwX18xGSPxKHSMB94sB3PuUwhq1H_hjDdg4pL1-IMFEubaV3WZWDozkgRPRzKX3H3gwwJnp_fq_Yz6-3Dzffq_sf3-5uvtxX2GiZq845szaNRgVGazAKoRmca6BF1zndSr0G6Ppe9YRaN00_tJJkj9j0BjuF-op9OvWW3X4dKGU7-bQcCDOFQ7KLPaFlK2RB2xOKMaQUabCP0U8Qn60UdpFu9_Ys_W_MCmmL9JL7eB5x6Cdy_1P_LBfg8wmgcujRU7QJPRXVzkfCbF3wL4z4AwGLmIU</recordid><startdate>201804</startdate><enddate>201804</enddate><creator>Ichikawa, Tomohiro</creator><creator>Aokage, Keiju</creator><creator>Sugano, Masato</creator><creator>Miyoshi, Tomohiro</creator><creator>Kojima, Motohiro</creator><creator>Fujii, Satoshi</creator><creator>Kuwata, Takeshi</creator><creator>Ochiai, Atsushi</creator><creator>Suzuki, Kenji</creator><creator>Tsuboi, Masahiro</creator><creator>Ishii, Genichiro</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201804</creationdate><title>The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma</title><author>Ichikawa, Tomohiro ; Aokage, Keiju ; Sugano, Masato ; Miyoshi, Tomohiro ; Kojima, Motohiro ; Fujii, Satoshi ; Kuwata, Takeshi ; Ochiai, Atsushi ; Suzuki, Kenji ; Tsuboi, Masahiro ; Ishii, Genichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-8dd96943c2a933a92ca4fdd4a5cd8d35136aa8bb2bec3344bf51e1bcc4b9c82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer cell ratio</topic><topic>Elastic fiber</topic><topic>Elastic Tissue - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Invasive area</topic><topic>Lung adenocarcinoma</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Paraffin Embedding</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Stromal Cells - pathology</topic><topic>Survival Analysis</topic><topic>Tumor Microenvironment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ichikawa, Tomohiro</creatorcontrib><creatorcontrib>Aokage, Keiju</creatorcontrib><creatorcontrib>Sugano, Masato</creatorcontrib><creatorcontrib>Miyoshi, Tomohiro</creatorcontrib><creatorcontrib>Kojima, Motohiro</creatorcontrib><creatorcontrib>Fujii, Satoshi</creatorcontrib><creatorcontrib>Kuwata, Takeshi</creatorcontrib><creatorcontrib>Ochiai, Atsushi</creatorcontrib><creatorcontrib>Suzuki, Kenji</creatorcontrib><creatorcontrib>Tsuboi, Masahiro</creatorcontrib><creatorcontrib>Ishii, Genichiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ichikawa, Tomohiro</au><au>Aokage, Keiju</au><au>Sugano, Masato</au><au>Miyoshi, Tomohiro</au><au>Kojima, Motohiro</au><au>Fujii, Satoshi</au><au>Kuwata, Takeshi</au><au>Ochiai, Atsushi</au><au>Suzuki, Kenji</au><au>Tsuboi, Masahiro</au><au>Ishii, Genichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma</atitle><jtitle>Lung cancer (Amsterdam, Netherlands)</jtitle><addtitle>Lung Cancer</addtitle><date>2018-04</date><risdate>2018</risdate><volume>118</volume><spage>30</spage><epage>35</epage><pages>30-35</pages><issn>0169-5002</issn><eissn>1872-8332</eissn><abstract>•Low proportion of cancer cells in the invasive area had better prognosis.•This was associated with the greater proportion of VVG-positive elastic fibers.•The character of the invasive area could be a useful histologic prognostic parameter.
This study evaluated whether the proportion of cancer cells to non-cancerous stroma within the invasive area is associated with the prognosis of patients with lung adenocarcinoma.
A total of 127 patients with lung adenocarcinomas with tumors larger than 3 cm in total size were enrolled in this study. We classified the tumors according to the ratio of area occupied by cancer cells within the invasive area (Type A: more than 50% of the invasive area, Type B: 10–50%, and Type C: less than 10%) and analyzed the clinicopathological differences between Types A, B, and C.
The invasive size of Type A tumors (n = 35) was significantly larger than those of the other two tumor types; however, there was no significant difference in the invasive size between Types B (n = 65) and C (n = 25) tumors. The recurrence-free survival time of patients with Type C tumors was significantly longer than those of patients with Type A and B (P < .001) tumors. Multivariate analysis revealed that Type C tumor was an independent favorable prognostic factor (P = .037) but that invasive size was not. The invasive area of Type C tumor was composed of a significantly higher proportion of collapsed elastic fibers than the invasive areas of Type A and B tumors (P < .001).
A lower cancer cell to stroma ratio within the invasive area could be a significant prognostic factor in lung adenocarcinoma, suggesting that not only the invasive size but also the invasive character might be an important histologic prognostic parameter.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>29571999</pmid><doi>10.1016/j.lungcan.2018.01.023</doi><tpages>6</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - mortality Adenocarcinoma - pathology Adult Aged Aged, 80 and over Cancer cell ratio Elastic fiber Elastic Tissue - pathology Female Humans Invasive area Lung adenocarcinoma Lung Neoplasms - diagnosis Lung Neoplasms - mortality Lung Neoplasms - pathology Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Paraffin Embedding Predictive Value of Tests Prognosis Stromal Cells - pathology Survival Analysis Tumor Microenvironment |
| title | The ratio of cancer cells to stroma within the invasive area is a histologic prognostic parameter of lung adenocarcinoma |
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