Ubiquitin‐Specific Protease 4 Is an Endogenous Negative Regulator of Metabolic Dysfunctions in Nonalcoholic Fatty Liver Disease in Mice

Nonalcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis (HS), insulin resistance (IR), and inflammation, poses a high risk of cardiometabolic disorders. Ubiquitin specific protease 4 (USP4), a deubiquitinating enzyme, is pivotally involved in regulating multiple inflammatory pat...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2018-09, Vol.68 (3), p.897-917
Hauptverfasser:	Zhao, Yichao, Wang, Fang, Gao, Lingchen, Xu, Longwei, Tong, Renyang, Lin, Nan, Su, Yuanyuan, Yan, Yang, Gao, Yu, He, Jie, Kong, Lingcong, Yuan, Ancai, Zhuge, Ying, Pu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Animal models Animals Fatty liver Glycogen Glycogen synthase kinase 3 Hepatocytes Hepatocytes - enzymology Hepatology High fat diet Humans Inflammation Insulin Insulin Resistance JNK protein Kinases Leptin - deficiency Liver - enzymology Liver diseases Male MAP Kinase Signaling System Metabolic disorders Metabolism Mice, Transgenic Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic Fatty Liver Disease - etiology Nutrient deficiency Obesity - enzymology Palmitic acid Proteinase Rodents Steatosis TAK1 protein Transforming growth factor Transforming growth factor-b Ubiquitin Ubiquitin-Specific Proteases - metabolism
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