Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia
Objective To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH). Methods Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imagi...
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| Veröffentlicht in: | Prenatal diagnosis 2018-05, Vol.38 (6), p.422-427 |
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| container_title | Prenatal diagnosis |
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| creator | Cruz‐Lemini, Mónica Valenzuela‐Alcaraz, Brenda Granados‐Montiel, Julio Martínez, Josep M. Crispi, Fátima Gratacós, Eduard Cruz‐Martínez, Rogelio |
| description | Objective
To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH).
Methods
Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E/E′ and E′/A′ ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left‐sided CDH fetuses and compared with 75 controls matched for gestational age 2:1.
Results
In comparison to controls, CDH fetuses had prolonged isovolumetric time periods (isovolumetric contraction time 35 ms vs 28 ms, P |
| doi_str_mv | 10.1002/pd.5253 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2018027091</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2047456639</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3453-2f9cd7c8141bdcb221baaa437f201b228c8bd38606a0879b9e2b9e3ed37d89153</originalsourceid><addsrcrecordid>eNp10E1LwzAYB_AgiptT_AYS8KAgnXlpl-Qo8xUGelA8ljRJt4w2rUnLmJ_ezE0PgoeQBH7Pn4c_AKcYjTFC5LrV44xkdA8MMRIsQYTQfTBEOL4pz_AAHIWwjJATwQ7BgIiMEc7oELxPF9JL1RlvP62bQyW9tlJBvQ5l71RnGwetg6Xp-mACXNluAStTdlA1bm6c7WQF40C78HJey84quDDeWXkMDkpZBXOyu0fg7f7udfqYzJ4fnqY3s0TRNKMJKYXSTHGc4kKrghBcSClTykqCcPxyxQtN-QRNJOJMFMKQeKjRlGkucEZH4HKb2_rmozehy2sblKkq6UzThzzGcEQYEjjS8z902fTexe2iSlmaTSZURHWxVco3IXhT5q23tfTrHKN803Xe6nzTdZRnu7y-qI3-dT_lRnC1BStbmfV_OfnL7XfcF_9whtw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047456639</pqid></control><display><type>article</type><title>Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Cruz‐Lemini, Mónica ; Valenzuela‐Alcaraz, Brenda ; Granados‐Montiel, Julio ; Martínez, Josep M. ; Crispi, Fátima ; Gratacós, Eduard ; Cruz‐Martínez, Rogelio</creator><creatorcontrib>Cruz‐Lemini, Mónica ; Valenzuela‐Alcaraz, Brenda ; Granados‐Montiel, Julio ; Martínez, Josep M. ; Crispi, Fátima ; Gratacós, Eduard ; Cruz‐Martínez, Rogelio</creatorcontrib><description>Objective
To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH).
Methods
Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E/E′ and E′/A′ ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left‐sided CDH fetuses and compared with 75 controls matched for gestational age 2:1.
Results
In comparison to controls, CDH fetuses had prolonged isovolumetric time periods (isovolumetric contraction time 35 ms vs 28 ms, P < .001), with higher myocardial performance index (0.49 vs 0.42, P < .001) and tricuspid E/A ratios (0.77 vs 0.72, P = .033). Longitudinal function assessed by tissue Doppler showed signs of impaired relaxation (mitral lateral A′ 8.0 vs 10.1 cm/s, P < .001 and an increased mitral lateral E′/A′ ratio 0.93 vs 0.78, P < .001) in the CDH fetuses as compared with controls, with preserved systolic function.
Conclusion
Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.
What is already known about this topic?
Fetuses with left CDH have shown decreased left cardiac output, higher strain values, and smaller left heart structures.
Tissue Doppler imaging permits evaluation of longitudinal myocardial motion and may be more accurate in describing myocardial function in CDH.
What does this study add?
This study evaluates for the first time TDI parameters in fetuses with left CDH.
Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.5253</identifier><identifier>PMID: 29572873</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adult ; Case-Control Studies ; Compression ; Contraction ; Doppler effect ; Echocardiography ; Female ; Fetal Heart - diagnostic imaging ; Fetal Heart - physiopathology ; Fetuses ; Gestational age ; Heart ; Heart diseases ; Hernia ; Hernias ; Hernias, Diaphragmatic, Congenital - diagnostic imaging ; Hernias, Diaphragmatic, Congenital - physiopathology ; Humans ; Performance indices ; Pregnancy ; Prenatal development ; Prospective Studies ; Ultrasonography, Prenatal ; Ventricle</subject><ispartof>Prenatal diagnosis, 2018-05, Vol.38 (6), p.422-427</ispartof><rights>2018 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3453-2f9cd7c8141bdcb221baaa437f201b228c8bd38606a0879b9e2b9e3ed37d89153</citedby><cites>FETCH-LOGICAL-c3453-2f9cd7c8141bdcb221baaa437f201b228c8bd38606a0879b9e2b9e3ed37d89153</cites><orcidid>0000-0001-5999-866X ; 0000-0002-6807-3578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.5253$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.5253$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29572873$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cruz‐Lemini, Mónica</creatorcontrib><creatorcontrib>Valenzuela‐Alcaraz, Brenda</creatorcontrib><creatorcontrib>Granados‐Montiel, Julio</creatorcontrib><creatorcontrib>Martínez, Josep M.</creatorcontrib><creatorcontrib>Crispi, Fátima</creatorcontrib><creatorcontrib>Gratacós, Eduard</creatorcontrib><creatorcontrib>Cruz‐Martínez, Rogelio</creatorcontrib><title>Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia</title><title>Prenatal diagnosis</title><addtitle>Prenat Diagn</addtitle><description>Objective
To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH).
Methods
Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E/E′ and E′/A′ ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left‐sided CDH fetuses and compared with 75 controls matched for gestational age 2:1.
Results
In comparison to controls, CDH fetuses had prolonged isovolumetric time periods (isovolumetric contraction time 35 ms vs 28 ms, P < .001), with higher myocardial performance index (0.49 vs 0.42, P < .001) and tricuspid E/A ratios (0.77 vs 0.72, P = .033). Longitudinal function assessed by tissue Doppler showed signs of impaired relaxation (mitral lateral A′ 8.0 vs 10.1 cm/s, P < .001 and an increased mitral lateral E′/A′ ratio 0.93 vs 0.78, P < .001) in the CDH fetuses as compared with controls, with preserved systolic function.
Conclusion
Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.
What is already known about this topic?
Fetuses with left CDH have shown decreased left cardiac output, higher strain values, and smaller left heart structures.
Tissue Doppler imaging permits evaluation of longitudinal myocardial motion and may be more accurate in describing myocardial function in CDH.
What does this study add?
This study evaluates for the first time TDI parameters in fetuses with left CDH.
Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Compression</subject><subject>Contraction</subject><subject>Doppler effect</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Fetal Heart - diagnostic imaging</subject><subject>Fetal Heart - physiopathology</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hernia</subject><subject>Hernias</subject><subject>Hernias, Diaphragmatic, Congenital - diagnostic imaging</subject><subject>Hernias, Diaphragmatic, Congenital - physiopathology</subject><subject>Humans</subject><subject>Performance indices</subject><subject>Pregnancy</subject><subject>Prenatal development</subject><subject>Prospective Studies</subject><subject>Ultrasonography, Prenatal</subject><subject>Ventricle</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1LwzAYB_AgiptT_AYS8KAgnXlpl-Qo8xUGelA8ljRJt4w2rUnLmJ_ezE0PgoeQBH7Pn4c_AKcYjTFC5LrV44xkdA8MMRIsQYTQfTBEOL4pz_AAHIWwjJATwQ7BgIiMEc7oELxPF9JL1RlvP62bQyW9tlJBvQ5l71RnGwetg6Xp-mACXNluAStTdlA1bm6c7WQF40C78HJey84quDDeWXkMDkpZBXOyu0fg7f7udfqYzJ4fnqY3s0TRNKMJKYXSTHGc4kKrghBcSClTykqCcPxyxQtN-QRNJOJMFMKQeKjRlGkucEZH4HKb2_rmozehy2sblKkq6UzThzzGcEQYEjjS8z902fTexe2iSlmaTSZURHWxVco3IXhT5q23tfTrHKN803Xe6nzTdZRnu7y-qI3-dT_lRnC1BStbmfV_OfnL7XfcF_9whtw</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Cruz‐Lemini, Mónica</creator><creator>Valenzuela‐Alcaraz, Brenda</creator><creator>Granados‐Montiel, Julio</creator><creator>Martínez, Josep M.</creator><creator>Crispi, Fátima</creator><creator>Gratacós, Eduard</creator><creator>Cruz‐Martínez, Rogelio</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5999-866X</orcidid><orcidid>https://orcid.org/0000-0002-6807-3578</orcidid></search><sort><creationdate>201805</creationdate><title>Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia</title><author>Cruz‐Lemini, Mónica ; Valenzuela‐Alcaraz, Brenda ; Granados‐Montiel, Julio ; Martínez, Josep M. ; Crispi, Fátima ; Gratacós, Eduard ; Cruz‐Martínez, Rogelio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3453-2f9cd7c8141bdcb221baaa437f201b228c8bd38606a0879b9e2b9e3ed37d89153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Compression</topic><topic>Contraction</topic><topic>Doppler effect</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Fetal Heart - diagnostic imaging</topic><topic>Fetal Heart - physiopathology</topic><topic>Fetuses</topic><topic>Gestational age</topic><topic>Heart</topic><topic>Heart diseases</topic><topic>Hernia</topic><topic>Hernias</topic><topic>Hernias, Diaphragmatic, Congenital - diagnostic imaging</topic><topic>Hernias, Diaphragmatic, Congenital - physiopathology</topic><topic>Humans</topic><topic>Performance indices</topic><topic>Pregnancy</topic><topic>Prenatal development</topic><topic>Prospective Studies</topic><topic>Ultrasonography, Prenatal</topic><topic>Ventricle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cruz‐Lemini, Mónica</creatorcontrib><creatorcontrib>Valenzuela‐Alcaraz, Brenda</creatorcontrib><creatorcontrib>Granados‐Montiel, Julio</creatorcontrib><creatorcontrib>Martínez, Josep M.</creatorcontrib><creatorcontrib>Crispi, Fátima</creatorcontrib><creatorcontrib>Gratacós, Eduard</creatorcontrib><creatorcontrib>Cruz‐Martínez, Rogelio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cruz‐Lemini, Mónica</au><au>Valenzuela‐Alcaraz, Brenda</au><au>Granados‐Montiel, Julio</au><au>Martínez, Josep M.</au><au>Crispi, Fátima</au><au>Gratacós, Eduard</au><au>Cruz‐Martínez, Rogelio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat Diagn</addtitle><date>2018-05</date><risdate>2018</risdate><volume>38</volume><issue>6</issue><spage>422</spage><epage>427</epage><pages>422-427</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><abstract>Objective
To evaluate cardiac function by conventional echocardiography and tissue Doppler imaging in fetuses with left congenital diaphragmatic hernia (CDH).
Methods
Conventional echocardiography (myocardial performance index, ventricular filling velocities, and E/A ratios) and tissue Doppler imaging (annular myocardial peak velocities, E/E′ and E′/A′ ratios) in mitral, septal, and tricuspid annulus were evaluated in a cohort of 31 left‐sided CDH fetuses and compared with 75 controls matched for gestational age 2:1.
Results
In comparison to controls, CDH fetuses had prolonged isovolumetric time periods (isovolumetric contraction time 35 ms vs 28 ms, P < .001), with higher myocardial performance index (0.49 vs 0.42, P < .001) and tricuspid E/A ratios (0.77 vs 0.72, P = .033). Longitudinal function assessed by tissue Doppler showed signs of impaired relaxation (mitral lateral A′ 8.0 vs 10.1 cm/s, P < .001 and an increased mitral lateral E′/A′ ratio 0.93 vs 0.78, P < .001) in the CDH fetuses as compared with controls, with preserved systolic function.
Conclusion
Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.
What is already known about this topic?
Fetuses with left CDH have shown decreased left cardiac output, higher strain values, and smaller left heart structures.
Tissue Doppler imaging permits evaluation of longitudinal myocardial motion and may be more accurate in describing myocardial function in CDH.
What does this study add?
This study evaluates for the first time TDI parameters in fetuses with left CDH.
Left CDH fetuses show echocardiographic signs of diastolic dysfunction, probably secondary to fetal heart compression, maintaining a preserved systolic function.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29572873</pmid><doi>10.1002/pd.5253</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5999-866X</orcidid><orcidid>https://orcid.org/0000-0002-6807-3578</orcidid></addata></record> |
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| ispartof | Prenatal diagnosis, 2018-05, Vol.38 (6), p.422-427 |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Case-Control Studies Compression Contraction Doppler effect Echocardiography Female Fetal Heart - diagnostic imaging Fetal Heart - physiopathology Fetuses Gestational age Heart Heart diseases Hernia Hernias Hernias, Diaphragmatic, Congenital - diagnostic imaging Hernias, Diaphragmatic, Congenital - physiopathology Humans Performance indices Pregnancy Prenatal development Prospective Studies Ultrasonography, Prenatal Ventricle |
| title | Characterizing cardiac dysfunction in fetuses with left congenital diaphragmatic hernia |
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