MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation
MARCH2 is one of the MARCH family E3 ligases, which contains eleven members that play pivotal roles in controlling the turn-over of membrane proteins, such as MHC class I, MHC class II, and cell surface receptors. In this study, we found the expression of MARCH2 to be upregulated upon HIV-1 infectio...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2018-05, Vol.518, p.293-300 |
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| creator | Zhang, You Lu, Jing Liu, Xinqi |
| description | MARCH2 is one of the MARCH family E3 ligases, which contains eleven members that play pivotal roles in controlling the turn-over of membrane proteins, such as MHC class I, MHC class II, and cell surface receptors. In this study, we found the expression of MARCH2 to be upregulated upon HIV-1 infection. MARCH2 inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention, a mechanism shared by MARCH8 that also leads to the inhibition of HIV-1 infection. Nevertheless, unlike MARCH8 and other MARCH proteins whose transcription levels are unrelated to viral infection, the expression level of MARCH2 is markedly upregulated upon HIV-1 infection, conferring MARCH2 a unique role in monitoring and regulating the HIV-1 infection-associated process.
•The expression level of MARCH2 is dramatically upregulated upon HIV infection.•MARCH2 overexpression reduces HIV-1 production.•Knockdown of MARCH2 increases viral production.•MARCH2 degrades VSV-G via lysosome and reduces Env from the plasma membrane.•The function of MARCH2 is ligase activity-dependent. |
| doi_str_mv | 10.1016/j.virol.2018.02.003 |
| format | Article |
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•The expression level of MARCH2 is dramatically upregulated upon HIV infection.•MARCH2 overexpression reduces HIV-1 production.•Knockdown of MARCH2 increases viral production.•MARCH2 degrades VSV-G via lysosome and reduces Env from the plasma membrane.•The function of MARCH2 is ligase activity-dependent.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2018.02.003</identifier><identifier>PMID: 29573664</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blotting, Western ; Carrier Proteins - metabolism ; Cell Line ; env Gene Products, Human Immunodeficiency Virus - metabolism ; Envelope proteins ; Gene Expression Profiling ; gene expression regulation ; HIV infections ; HIV Infections - immunology ; HIV-1 ; HIV-1 - immunology ; Host-Pathogen Interactions ; Human immunodeficiency virus 1 ; Humans ; ligases ; major histocompatibility complex ; MARCH2 ; membrane proteins ; Membrane Proteins - metabolism ; Microscopy, Fluorescence ; monitoring ; protein degradation ; Protein Transport ; Proteolysis ; Real-Time Polymerase Chain Reaction ; receptors ; Up-Regulation ; Viral inhibition</subject><ispartof>Virology (New York, N.Y.), 2018-05, Vol.518, p.293-300</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-ac94c40f0af28b37488af65797a2a918ad502c2fa34d24fc27152660be67fbf33</citedby><cites>FETCH-LOGICAL-c458t-ac94c40f0af28b37488af65797a2a918ad502c2fa34d24fc27152660be67fbf33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0042682218300400$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29573664$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, You</creatorcontrib><creatorcontrib>Lu, Jing</creatorcontrib><creatorcontrib>Liu, Xinqi</creatorcontrib><title>MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation</title><title>Virology (New York, N.Y.)</title><addtitle>Virology</addtitle><description>MARCH2 is one of the MARCH family E3 ligases, which contains eleven members that play pivotal roles in controlling the turn-over of membrane proteins, such as MHC class I, MHC class II, and cell surface receptors. In this study, we found the expression of MARCH2 to be upregulated upon HIV-1 infection. MARCH2 inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention, a mechanism shared by MARCH8 that also leads to the inhibition of HIV-1 infection. Nevertheless, unlike MARCH8 and other MARCH proteins whose transcription levels are unrelated to viral infection, the expression level of MARCH2 is markedly upregulated upon HIV-1 infection, conferring MARCH2 a unique role in monitoring and regulating the HIV-1 infection-associated process.
•The expression level of MARCH2 is dramatically upregulated upon HIV infection.•MARCH2 overexpression reduces HIV-1 production.•Knockdown of MARCH2 increases viral production.•MARCH2 degrades VSV-G via lysosome and reduces Env from the plasma membrane.•The function of MARCH2 is ligase activity-dependent.</description><subject>Blotting, Western</subject><subject>Carrier Proteins - metabolism</subject><subject>Cell Line</subject><subject>env Gene Products, Human Immunodeficiency Virus - metabolism</subject><subject>Envelope proteins</subject><subject>Gene Expression Profiling</subject><subject>gene expression regulation</subject><subject>HIV infections</subject><subject>HIV Infections - immunology</subject><subject>HIV-1</subject><subject>HIV-1 - immunology</subject><subject>Host-Pathogen Interactions</subject><subject>Human immunodeficiency virus 1</subject><subject>Humans</subject><subject>ligases</subject><subject>major histocompatibility complex</subject><subject>MARCH2</subject><subject>membrane proteins</subject><subject>Membrane Proteins - metabolism</subject><subject>Microscopy, Fluorescence</subject><subject>monitoring</subject><subject>protein degradation</subject><subject>Protein Transport</subject><subject>Proteolysis</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>receptors</subject><subject>Up-Regulation</subject><subject>Viral inhibition</subject><issn>0042-6822</issn><issn>1096-0341</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxS1ERZfCJ0BCOXJJGNuJ7Rw4VKvCViqqVBWuluOMd73KxoudrITEh8f7B45wssfv92aseYS8o1BRoOLjtjr4GIaKAVUVsAqAvyALCq0ogdf0JVkA1KwUirFr8jqlLeRaSnhFrlnbSC5EvSC_vt4-LVes8KmY9xHX82Am7As_Fqv77yXNF4d28mEszHh83vjOT-ki7mPo57M6bWKY15sCxwMOYY9HbcLcZopmTEOw5oSFWPS4jqY_lW_IlTNDwreX84Z8-3z3vFyVD49f7pe3D6WtGzWVxra1rcGBcUx1XNZKGSca2UrDTEuV6RtgljnD657VzjJJGyYEdCik6xznN-TDuW_-1I8Z06R3PlkcBjNimJNmrRIMhOTq_2heNrCMthnlZ9TGkFJEp_fR70z8qSnoY0J6q08JnUwamM4JZdf7y4C522H_1_Mnkgx8OgOYN3LwGHWyHkeLvY85Ct0H_88BvwFwE6NU</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Zhang, You</creator><creator>Lu, Jing</creator><creator>Liu, Xinqi</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>201805</creationdate><title>MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation</title><author>Zhang, You ; Lu, Jing ; Liu, Xinqi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-ac94c40f0af28b37488af65797a2a918ad502c2fa34d24fc27152660be67fbf33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Blotting, Western</topic><topic>Carrier Proteins - metabolism</topic><topic>Cell Line</topic><topic>env Gene Products, Human Immunodeficiency Virus - metabolism</topic><topic>Envelope proteins</topic><topic>Gene Expression Profiling</topic><topic>gene expression regulation</topic><topic>HIV infections</topic><topic>HIV Infections - immunology</topic><topic>HIV-1</topic><topic>HIV-1 - immunology</topic><topic>Host-Pathogen Interactions</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>ligases</topic><topic>major histocompatibility complex</topic><topic>MARCH2</topic><topic>membrane proteins</topic><topic>Membrane Proteins - metabolism</topic><topic>Microscopy, Fluorescence</topic><topic>monitoring</topic><topic>protein degradation</topic><topic>Protein Transport</topic><topic>Proteolysis</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>receptors</topic><topic>Up-Regulation</topic><topic>Viral inhibition</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, You</creatorcontrib><creatorcontrib>Lu, Jing</creatorcontrib><creatorcontrib>Liu, Xinqi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Virology (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, You</au><au>Lu, Jing</au><au>Liu, Xinqi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation</atitle><jtitle>Virology (New York, N.Y.)</jtitle><addtitle>Virology</addtitle><date>2018-05</date><risdate>2018</risdate><volume>518</volume><spage>293</spage><epage>300</epage><pages>293-300</pages><issn>0042-6822</issn><eissn>1096-0341</eissn><abstract>MARCH2 is one of the MARCH family E3 ligases, which contains eleven members that play pivotal roles in controlling the turn-over of membrane proteins, such as MHC class I, MHC class II, and cell surface receptors. In this study, we found the expression of MARCH2 to be upregulated upon HIV-1 infection. MARCH2 inhibits the production and infection of HIV-1 through ligase activity-dependent envelope protein degradation and/or intracellular retention, a mechanism shared by MARCH8 that also leads to the inhibition of HIV-1 infection. Nevertheless, unlike MARCH8 and other MARCH proteins whose transcription levels are unrelated to viral infection, the expression level of MARCH2 is markedly upregulated upon HIV-1 infection, conferring MARCH2 a unique role in monitoring and regulating the HIV-1 infection-associated process.
•The expression level of MARCH2 is dramatically upregulated upon HIV infection.•MARCH2 overexpression reduces HIV-1 production.•Knockdown of MARCH2 increases viral production.•MARCH2 degrades VSV-G via lysosome and reduces Env from the plasma membrane.•The function of MARCH2 is ligase activity-dependent.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29573664</pmid><doi>10.1016/j.virol.2018.02.003</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB Electronic Journals Library |
| subjects | Blotting, Western Carrier Proteins - metabolism Cell Line env Gene Products, Human Immunodeficiency Virus - metabolism Envelope proteins Gene Expression Profiling gene expression regulation HIV infections HIV Infections - immunology HIV-1 HIV-1 - immunology Host-Pathogen Interactions Human immunodeficiency virus 1 Humans ligases major histocompatibility complex MARCH2 membrane proteins Membrane Proteins - metabolism Microscopy, Fluorescence monitoring protein degradation Protein Transport Proteolysis Real-Time Polymerase Chain Reaction receptors Up-Regulation Viral inhibition |
| title | MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation |
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