Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy
Herein, poly(pyrrole-3-carboxylic acid) (PPyCOOH) nanoneedles with abundant carboxyl groups were synthesized by aqueous dispersion polymerization method using pyrrole-3-carboxylic acid as conductive polymer monomer. The PPyCOOH nanoneedles not only owned good photothermal performance, but also more...
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| Veröffentlicht in: | Biomaterials 2018-06, Vol.167, p.177-190 |
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| creator | Liu, Xin Su, Huiling Shi, Wei Liu, Yang Sun, Yanan Ge, Dongtao |
| description | Herein, poly(pyrrole-3-carboxylic acid) (PPyCOOH) nanoneedles with abundant carboxyl groups were synthesized by aqueous dispersion polymerization method using pyrrole-3-carboxylic acid as conductive polymer monomer. The PPyCOOH nanoneedles not only owned good photothermal performance, but also more importantly showed enhanced tumor cell uptake efficiency (1.64 fold) compared with size and zeta-potential matched nanospheres. After loading photosensitizer aluminum phthalocyanine tetrasulfonate (AlPCS4) and modifying with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) onto the PPyCOOH nanoneedles, novel nanoneedle complexes (AlPCS4@PPyCONH-PAH-PAA) integrating photodynamic therapy (PDT) and photothermal therapy (PTT) were successfully fabricated. The as-prepared nanoneedle complexes improved uptake efficiency of AlPCS4 both in vitro and in vivo. Moreover, the nanoneedle complexes have infrared thermal and fluorescent properties. By combined PDT/PTT under the guiding of dual modal imaging, the tumors in mice were completely eliminated and no recurrence was observed in 30 days after treatment, indicating that PPyCOOH nanoneedles have great potential as a novel drug carrier for constructing multifunctional nanoplatform used for cancer treatment. |
| doi_str_mv | 10.1016/j.biomaterials.2018.03.030 |
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The PPyCOOH nanoneedles not only owned good photothermal performance, but also more importantly showed enhanced tumor cell uptake efficiency (1.64 fold) compared with size and zeta-potential matched nanospheres. After loading photosensitizer aluminum phthalocyanine tetrasulfonate (AlPCS4) and modifying with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) onto the PPyCOOH nanoneedles, novel nanoneedle complexes (AlPCS4@PPyCONH-PAH-PAA) integrating photodynamic therapy (PDT) and photothermal therapy (PTT) were successfully fabricated. The as-prepared nanoneedle complexes improved uptake efficiency of AlPCS4 both in vitro and in vivo. Moreover, the nanoneedle complexes have infrared thermal and fluorescent properties. By combined PDT/PTT under the guiding of dual modal imaging, the tumors in mice were completely eliminated and no recurrence was observed in 30 days after treatment, indicating that PPyCOOH nanoneedles have great potential as a novel drug carrier for constructing multifunctional nanoplatform used for cancer treatment.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2018.03.030</identifier><identifier>PMID: 29571053</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; Carboxylic Acids - therapeutic use ; Combined Modality Therapy - methods ; Dual-imaging guided ; Female ; HeLa Cells ; Humans ; Hyperthermia, Induced - methods ; Indoles - therapeutic use ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Nanoneedle ; Nanostructures - therapeutic use ; Neoplasms - diagnostic imaging ; Neoplasms - therapy ; Optical Imaging - methods ; Organometallic Compounds - therapeutic use ; Photochemotherapy - methods ; Photodynamic therapy ; Photosensitizing Agents - therapeutic use ; Photothermal therapy ; Poly(pyrrole-3-carboxylic acid) ; Polymers - therapeutic use ; Pyrroles - therapeutic use ; RAW 264.7 Cells ; Theranostic Nanomedicine - methods ; Thermography - methods</subject><ispartof>Biomaterials, 2018-06, Vol.167, p.177-190</ispartof><rights>2018</rights><rights>Copyright © 2018. Published by Elsevier Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-27c2e4f73ae5f1ebbd641950ecd65863ea7bc865ba8c7d1618e8ae2b26bf69a53</citedby><cites>FETCH-LOGICAL-c380t-27c2e4f73ae5f1ebbd641950ecd65863ea7bc865ba8c7d1618e8ae2b26bf69a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961218301972$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29571053$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Su, Huiling</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Sun, Yanan</creatorcontrib><creatorcontrib>Ge, Dongtao</creatorcontrib><title>Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Herein, poly(pyrrole-3-carboxylic acid) (PPyCOOH) nanoneedles with abundant carboxyl groups were synthesized by aqueous dispersion polymerization method using pyrrole-3-carboxylic acid as conductive polymer monomer. The PPyCOOH nanoneedles not only owned good photothermal performance, but also more importantly showed enhanced tumor cell uptake efficiency (1.64 fold) compared with size and zeta-potential matched nanospheres. After loading photosensitizer aluminum phthalocyanine tetrasulfonate (AlPCS4) and modifying with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) onto the PPyCOOH nanoneedles, novel nanoneedle complexes (AlPCS4@PPyCONH-PAH-PAA) integrating photodynamic therapy (PDT) and photothermal therapy (PTT) were successfully fabricated. The as-prepared nanoneedle complexes improved uptake efficiency of AlPCS4 both in vitro and in vivo. Moreover, the nanoneedle complexes have infrared thermal and fluorescent properties. By combined PDT/PTT under the guiding of dual modal imaging, the tumors in mice were completely eliminated and no recurrence was observed in 30 days after treatment, indicating that PPyCOOH nanoneedles have great potential as a novel drug carrier for constructing multifunctional nanoplatform used for cancer treatment.</description><subject>Animals</subject><subject>Carboxylic Acids - therapeutic use</subject><subject>Combined Modality Therapy - methods</subject><subject>Dual-imaging guided</subject><subject>Female</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hyperthermia, Induced - methods</subject><subject>Indoles - therapeutic use</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>Nanoneedle</subject><subject>Nanostructures - therapeutic use</subject><subject>Neoplasms - diagnostic imaging</subject><subject>Neoplasms - therapy</subject><subject>Optical Imaging - methods</subject><subject>Organometallic Compounds - therapeutic use</subject><subject>Photochemotherapy - methods</subject><subject>Photodynamic therapy</subject><subject>Photosensitizing Agents - therapeutic use</subject><subject>Photothermal therapy</subject><subject>Poly(pyrrole-3-carboxylic acid)</subject><subject>Polymers - therapeutic use</subject><subject>Pyrroles - therapeutic use</subject><subject>RAW 264.7 Cells</subject><subject>Theranostic Nanomedicine - methods</subject><subject>Thermography - methods</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUMtu1DAUtRCITgu_gCJWZZGpH-PEYYf6oEiV6GK6tvy4GTxy7GAnFeHr8XQK6hLpSldXOo97DkIfCV4TTJqL_Vq7OKgJklM-rykmYo1ZGfwKrYhoRc07zF-jFSYbWncNoSfoNOc9Ljfe0LfohHa8JZizFQo3czCTi0F59xtsNUa_nI9LStFDzWqjko6_Fu9MpYyzn6qgQgwA1kOu-pgqOytfu0HtXNhVu9nZonF_tb24324rEwftgjqoV9MPSGpc3qE3ffkZ3j_vM_Rwc729vK3vvn_9dvnlrjZM4KmmraGw6VumgPcEtLbNhnQcg7ENFw0D1WojGq6VMK0lDREgFFBNG903neLsDJ0fdccUf86QJzm4bMB7FSDOWR46w5QLzAr08xFqUsw5QS_HVAKlRRIsD33LvXzZ9xNXYlYGF_KHZ59ZD2D_Uf8WXABXRwCUtI8OkszGQTBgXQIzSRvd__j8ASRUmnE</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Liu, Xin</creator><creator>Su, Huiling</creator><creator>Shi, Wei</creator><creator>Liu, Yang</creator><creator>Sun, Yanan</creator><creator>Ge, Dongtao</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy</title><author>Liu, Xin ; Su, Huiling ; Shi, Wei ; Liu, Yang ; Sun, Yanan ; Ge, Dongtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-27c2e4f73ae5f1ebbd641950ecd65863ea7bc865ba8c7d1618e8ae2b26bf69a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Carboxylic Acids - therapeutic use</topic><topic>Combined Modality Therapy - methods</topic><topic>Dual-imaging guided</topic><topic>Female</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hyperthermia, Induced - methods</topic><topic>Indoles - therapeutic use</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>Nanoneedle</topic><topic>Nanostructures - therapeutic use</topic><topic>Neoplasms - diagnostic imaging</topic><topic>Neoplasms - therapy</topic><topic>Optical Imaging - methods</topic><topic>Organometallic Compounds - therapeutic use</topic><topic>Photochemotherapy - methods</topic><topic>Photodynamic therapy</topic><topic>Photosensitizing Agents - therapeutic use</topic><topic>Photothermal therapy</topic><topic>Poly(pyrrole-3-carboxylic acid)</topic><topic>Polymers - therapeutic use</topic><topic>Pyrroles - therapeutic use</topic><topic>RAW 264.7 Cells</topic><topic>Theranostic Nanomedicine - methods</topic><topic>Thermography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Xin</creatorcontrib><creatorcontrib>Su, Huiling</creatorcontrib><creatorcontrib>Shi, Wei</creatorcontrib><creatorcontrib>Liu, Yang</creatorcontrib><creatorcontrib>Sun, Yanan</creatorcontrib><creatorcontrib>Ge, Dongtao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Xin</au><au>Su, Huiling</au><au>Shi, Wei</au><au>Liu, Yang</au><au>Sun, Yanan</au><au>Ge, Dongtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2018-06</date><risdate>2018</risdate><volume>167</volume><spage>177</spage><epage>190</epage><pages>177-190</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Herein, poly(pyrrole-3-carboxylic acid) (PPyCOOH) nanoneedles with abundant carboxyl groups were synthesized by aqueous dispersion polymerization method using pyrrole-3-carboxylic acid as conductive polymer monomer. The PPyCOOH nanoneedles not only owned good photothermal performance, but also more importantly showed enhanced tumor cell uptake efficiency (1.64 fold) compared with size and zeta-potential matched nanospheres. After loading photosensitizer aluminum phthalocyanine tetrasulfonate (AlPCS4) and modifying with poly(allylamine hydrochloride) (PAH) and poly(acrylic acid) (PAA) onto the PPyCOOH nanoneedles, novel nanoneedle complexes (AlPCS4@PPyCONH-PAH-PAA) integrating photodynamic therapy (PDT) and photothermal therapy (PTT) were successfully fabricated. The as-prepared nanoneedle complexes improved uptake efficiency of AlPCS4 both in vitro and in vivo. Moreover, the nanoneedle complexes have infrared thermal and fluorescent properties. By combined PDT/PTT under the guiding of dual modal imaging, the tumors in mice were completely eliminated and no recurrence was observed in 30 days after treatment, indicating that PPyCOOH nanoneedles have great potential as a novel drug carrier for constructing multifunctional nanoplatform used for cancer treatment.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>29571053</pmid><doi>10.1016/j.biomaterials.2018.03.030</doi><tpages>14</tpages></addata></record> |
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| subjects | Animals Carboxylic Acids - therapeutic use Combined Modality Therapy - methods Dual-imaging guided Female HeLa Cells Humans Hyperthermia, Induced - methods Indoles - therapeutic use Mice Mice, Inbred BALB C Mice, Nude Nanoneedle Nanostructures - therapeutic use Neoplasms - diagnostic imaging Neoplasms - therapy Optical Imaging - methods Organometallic Compounds - therapeutic use Photochemotherapy - methods Photodynamic therapy Photosensitizing Agents - therapeutic use Photothermal therapy Poly(pyrrole-3-carboxylic acid) Polymers - therapeutic use Pyrroles - therapeutic use RAW 264.7 Cells Theranostic Nanomedicine - methods Thermography - methods |
| title | Functionalized poly(pyrrole-3-carboxylic acid) nanoneedles for dual-imaging guided PDT/PTT combination therapy |
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