Comprehensive Biochemical and Biophysical Characterization of Hemoglobin-Based Oxygen Carrier Therapeutics: All HBOCs Are Not Created Equally

The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) has been hampered because of safety concerns in humans. Chemical and/or genetic modifications of the Hb introduce varied structural and conformational constraint on the molecule that resulted in proteins with diverse allosteric respons...

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Veröffentlicht in:	Bioconjugate chemistry 2018-05, Vol.29 (5), p.1560-1575
Hauptverfasser:	Meng, Fantao, Kassa, Tigist, Jana, Sirsendu, Wood, Francine, Zhang, Xiaoyuan, Jia, Yiping, D’Agnillo, Felice, Alayash, Abdu I
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Animals Autoxidation Biochemistry Blood Substitutes - adverse effects Blood Substitutes - chemistry Blood Substitutes - metabolism Blood Substitutes - pharmacology Carbon Monoxide - metabolism Cattle Cell Line Electron transport Genetic engineering Heme Heme - chemistry Hemoglobin Hemoglobins - adverse effects Hemoglobins - chemistry Hemoglobins - genetics Hemoglobins - pharmacology Humans Kinetics Mice Mitochondria Molecular chains Organic chemistry Oxidation-Reduction Oxygen Oxygen - metabolism Protein Engineering Proteins Reaction kinetics Redox reactions Side reactions Structure-function relationships
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