In vitro antibacterial effects of statins against bacterial pathogens causing skin infections

With financial considerations impeding research and development of new antibiotics, drug repurposing (finding new indications for old drugs) emerges as a feasible alternative. Statins are extensively prescribed around the world to lower cholesterol, but they also possess inherent antimicrobial prope...

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Veröffentlicht in:	European journal of clinical microbiology & infectious diseases 2018-06, Vol.37 (6), p.1125-1135
Hauptverfasser:	Ko, Humphrey H. T., Lareu, Ricky R., Dix, Brett R., Hughes, Jeffery D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Anti-Infective Agents, Local - pharmacology Antibacterial activity Antibiotics Bacteria Biofilms Biomedical and Life Sciences Biomedicine Cell division Cholesterol Drug development Drug Discovery Drug Repositioning E coli Escherichia coli - drug effects Escherichia coli - pathogenicity Failure analysis Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Internal Medicine Medical Microbiology Metabolites Microbial Sensitivity Tests Original Article Pathogens Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - pathogenicity R&D Research & development Simvastatin Simvastatin - analogs & derivatives Simvastatin - pharmacology Skin Skin - microbiology Skin tests Staphylococcal Skin Infections - drug therapy Staphylococcal Skin Infections - microbiology Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Statins
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