Role of the JAKs/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons

Recent studies show that inflammation has an active role in the onset of neurodegenerative diseases. It is known that in response to extracellular insults microglia and/or astrocytes produce inflammatory agents. These contribute to the neuropathological events in the aging process and neuronal degen...

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Veröffentlicht in:	Neurotoxicity research 2005-11, Vol.8 (3-4), p.295-304
Hauptverfasser:	Orellana, D I, Quintanilla, R A, Gonzalez-Billault, C, Maccioni, R B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antibodies, Monoclonal - metabolism Blotting, Western - methods Calcium - metabolism Cells, Cultured Chelating Agents - pharmacology Dizocilpine Maleate - pharmacology Drug Interactions Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Fluorescent Antibody Technique - methods Hippocampus - cytology Interleukin-6 - pharmacology Intracellular Space - drug effects Intracellular Space - metabolism Janus Kinase 3 Neurons - drug effects Protein-Tyrosine Kinases - metabolism Rats Rats, Sprague-Dawley Signal Transduction - drug effects Signal Transduction - physiology STAT Transcription Factors - physiology Time Factors
Online-Zugang:	Volltext
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