NO-donors. Part 17 super(1): Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds

NO-donors. Part 17 super(1): Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds

Novel hybrid compounds combining the antifungal drug ketoconazole with a diazen-1-ium-1,2-diolate or an organic nitrate moiety and the corresponding NO-donors without ketoconazole were synthesized and their activities against a broad variety of fungal strains were tested. Hybridization modifies the...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2008-09, Vol.16 (17), p.8294-8300
Hauptverfasser: Konter, Joerg, Moellmann, Ute, Lehmann, Jochen
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Sprache:eng
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container_title Bioorganic & medicinal chemistry
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creator Konter, Joerg
Moellmann, Ute
Lehmann, Jochen
description Novel hybrid compounds combining the antifungal drug ketoconazole with a diazen-1-ium-1,2-diolate or an organic nitrate moiety and the corresponding NO-donors without ketoconazole were synthesized and their activities against a broad variety of fungal strains were tested. Hybridization modifies the spectrum of antimicrobial activities and generally, the ketoconazole-NO-donor hybrids are more potent than ketoconazole. The NO-donors alone show insufficient effectiveness.
doi_str_mv 10.1016/j.bmc.2008.05.008
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title NO-donors. Part 17 super(1): Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds
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