Effects of nicotine on sensorimotor gating impairment induced by long-term treatment with neurotoxic NMDA antagonism

In order to develop a model of persistent sensorimotor gating that did not require acute NMDA ( N -methyl-D-aspartate) receptor blockade, adult female Sprague-Dawley rats were pre-treated with N -methyl-scopolamine (1 mg/ kg s.c.), then administered MK-801 (dizocilpine, 5 mg/kg i.p.) along with two...

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Veröffentlicht in:	Neurotoxicity research 2008-09, Vol.13 (3-4), p.151-161
Hauptverfasser:	Rasmussen, Bruce A., Perry, David C., O’Neil, Jahn, Manaye, Kebreten F., Tizabi, Yousef
Format:	Artikel
Sprache:	eng
Schlagworte:	Acoustic Stimulation - methods Analysis of Variance Animals Biomedical and Life Sciences Biomedicine Bridged Bicyclo Compounds, Heterocyclic - metabolism Bungarotoxins - metabolism Cell Biology Disease Models, Animal Dizocilpine Maleate - administration & dosage Drug Administration Schedule Female Gait Disorders, Neurologic - chemically induced Gait Disorders, Neurologic - drug therapy Gait Disorders, Neurologic - physiopathology Inhibition (Psychology) Isotopes - metabolism Muscarinic Agonists - administration & dosage Muscarinic Antagonists - administration & dosage Neurobiology Neurochemistry Neurology Neurosciences Neurotoxins Nicotine - therapeutic use Nicotinic Agonists - therapeutic use Pharmacology/Toxicology Pilocarpine - administration & dosage Protein Binding - drug effects Pyridines - metabolism Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Receptors, Nicotinic - metabolism Reflex, Startle - drug effects Scopolamine Hydrobromide - administration & dosage
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