A chiral Brønsted acid-catalyzed highly enantioselective Mannich-type reaction of α-diazo esters with in situ generated N-acyl ketimines

A chiral phosphoric acid-catalyzed asymmetric Mannich-type reaction of α-diazo esters with in situ generated N-acyl ketimines, derived from 3-hydroxyisoindolinones has been demonstrated in this communication. A variety of isoindolinone-based α-amino diazo esters bearing a quaternary stereogenic cent...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2018-04, Vol.54 (28), p.3516-3519
Hauptverfasser:	Unhale, Rajshekhar A, Sadhu, Milon M, Ray, Sumit K, Biswas, Rayhan G, Singh, Vinod K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adducts Esters Imines Phosphoric acid
Online-Zugang:	Volltext
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