The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study
Background IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN). Methods Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney...
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| Veröffentlicht in: | Clinical and experimental nephrology 2018-10, Vol.22 (5), p.1116-1127 |
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| creator | Handa, Takaya Kakita, Hiroko Tateishi, Yu Endo, Tomomi Suzuki, Hiroyuki Katayama, Toshiro Tsukamoto, Tatsuo Muso, Eri |
| description | Background
IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN).
Methods
Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by > 50%. In addition, a 26-patient IgAN cohort (matching-IgAN), matching with IgA-IRGN group with respect to age, sex, estimated glomerular filtration rate (eGFR), and proteinuria was segregated for comparison.
Results
Compared to IgAN group, IgA-IRGN group were older, had lower hemoglobin, higher CRP, lower eGFR, heavier proteinuria, lower serum albumin, and higher serum IgG and IgA levels (
p
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| doi_str_mv | 10.1007/s10157-018-1564-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2017059148</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2017059148</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-ff0a4e806a1f9d4e92700c425ed775b4436a590cd7fedce704ff0c763231938b3</originalsourceid><addsrcrecordid>eNp1kU9rHCEYh6W0NH_aD5BLEHrpxVZndBxzC0ubBgK9pGdx9XXXMKNbdQL77eN20wYCPam8z-_3Cg9CF4x-YZTKr4VRJiShbCRMDJzwN-iU8V4SKZV62-497wiTgp2gs1IeKKWjEuo9OulUw4dBnKLH-y1gD6YuGQoOEd9urolLc4gm1vb2YGtIkWSYTAWHN1OaIS9TirDb5lBDwS6UGqKt2Oc0H_L4zyztTN3ur7DBJcTNBMRCrJBxqYvbf0DvvJkKfHw-z9Gv79_uVz_I3c-b29X1HbFcsEq8p4bDSAfDvHIcVCcptbwT4KQUa877wQhFrZMenAVJeUtYOfRdz1Q_rvtz9PnYu8vp9wKl6jkUC9NkIqSl6I4ySYVifGzop1foQ1pybL87UANrrb1qFDtSNqdSMni9y2E2ea8Z1Qcp-ihFNyn6IEXzlrl8bl7WM7h_ib8WGtAdgdJGcQP5ZfX_W58AASGYYg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2016176339</pqid></control><display><type>article</type><title>The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Handa, Takaya ; Kakita, Hiroko ; Tateishi, Yu ; Endo, Tomomi ; Suzuki, Hiroyuki ; Katayama, Toshiro ; Tsukamoto, Tatsuo ; Muso, Eri</creator><creatorcontrib>Handa, Takaya ; Kakita, Hiroko ; Tateishi, Yu ; Endo, Tomomi ; Suzuki, Hiroyuki ; Katayama, Toshiro ; Tsukamoto, Tatsuo ; Muso, Eri</creatorcontrib><description>Background
IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN).
Methods
Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by > 50%. In addition, a 26-patient IgAN cohort (matching-IgAN), matching with IgA-IRGN group with respect to age, sex, estimated glomerular filtration rate (eGFR), and proteinuria was segregated for comparison.
Results
Compared to IgAN group, IgA-IRGN group were older, had lower hemoglobin, higher CRP, lower eGFR, heavier proteinuria, lower serum albumin, and higher serum IgG and IgA levels (
p
< 0.05). Endocapillary hypercellularity, deposition of immune complexes along the glomerular capillary wall, and subendothelial and subepithelial electron dense deposits were more frequently observed (
p
< 0.05); and they were more susceptible to renal dysfunction and poorer prognosis. After propensity score-matching, serum albumin was significantly lower in the IgA-IRGN group. Significantly subendothelial and subepithelial deposits were frequently observed in this group. Matching-IgAN group showed relatively advanced sclerotic lesions with more global sclerosis and fibrous crescent.
Conclusion
Local inflammation involved glomerular capillary wall in IgA-IRGN, in contrast to relatively chronic and sclerotic renal lesion in IgAN, might result in poorer prognosis in former, even under indistinguishable condition of deteriorated renal function and proteinuria.</description><identifier>ISSN: 1342-1751</identifier><identifier>EISSN: 1437-7799</identifier><identifier>DOI: 10.1007/s10157-018-1564-4</identifier><identifier>PMID: 29564665</identifier><language>eng</language><publisher>Singapore: Springer Singapore</publisher><subject>Adult ; Aged ; Albumin ; Antigen-antibody complexes ; Biopsy ; Creatinine ; Epidermal growth factor receptors ; Female ; Glomerular filtration rate ; Glomerulonephritis ; Glomerulonephritis - etiology ; Glomerulonephritis, IGA - complications ; Hemoglobin ; Humans ; IgA nephropathy ; Immunofluorescence ; Immunoglobulin A ; Immunoglobulin G ; Infection - complications ; Kidney Glomerulus ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Original Article ; Prognosis ; Proteinuria ; Renal function ; Retrospective Studies ; Sclerosis ; Urology</subject><ispartof>Clinical and experimental nephrology, 2018-10, Vol.22 (5), p.1116-1127</ispartof><rights>Japanese Society of Nephrology 2018</rights><rights>Clinical and Experimental Nephrology is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-ff0a4e806a1f9d4e92700c425ed775b4436a590cd7fedce704ff0c763231938b3</citedby><cites>FETCH-LOGICAL-c451t-ff0a4e806a1f9d4e92700c425ed775b4436a590cd7fedce704ff0c763231938b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10157-018-1564-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10157-018-1564-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29564665$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handa, Takaya</creatorcontrib><creatorcontrib>Kakita, Hiroko</creatorcontrib><creatorcontrib>Tateishi, Yu</creatorcontrib><creatorcontrib>Endo, Tomomi</creatorcontrib><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Katayama, Toshiro</creatorcontrib><creatorcontrib>Tsukamoto, Tatsuo</creatorcontrib><creatorcontrib>Muso, Eri</creatorcontrib><title>The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study</title><title>Clinical and experimental nephrology</title><addtitle>Clin Exp Nephrol</addtitle><addtitle>Clin Exp Nephrol</addtitle><description>Background
IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN).
Methods
Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by > 50%. In addition, a 26-patient IgAN cohort (matching-IgAN), matching with IgA-IRGN group with respect to age, sex, estimated glomerular filtration rate (eGFR), and proteinuria was segregated for comparison.
Results
Compared to IgAN group, IgA-IRGN group were older, had lower hemoglobin, higher CRP, lower eGFR, heavier proteinuria, lower serum albumin, and higher serum IgG and IgA levels (
p
< 0.05). Endocapillary hypercellularity, deposition of immune complexes along the glomerular capillary wall, and subendothelial and subepithelial electron dense deposits were more frequently observed (
p
< 0.05); and they were more susceptible to renal dysfunction and poorer prognosis. After propensity score-matching, serum albumin was significantly lower in the IgA-IRGN group. Significantly subendothelial and subepithelial deposits were frequently observed in this group. Matching-IgAN group showed relatively advanced sclerotic lesions with more global sclerosis and fibrous crescent.
Conclusion
Local inflammation involved glomerular capillary wall in IgA-IRGN, in contrast to relatively chronic and sclerotic renal lesion in IgAN, might result in poorer prognosis in former, even under indistinguishable condition of deteriorated renal function and proteinuria.</description><subject>Adult</subject><subject>Aged</subject><subject>Albumin</subject><subject>Antigen-antibody complexes</subject><subject>Biopsy</subject><subject>Creatinine</subject><subject>Epidermal growth factor receptors</subject><subject>Female</subject><subject>Glomerular filtration rate</subject><subject>Glomerulonephritis</subject><subject>Glomerulonephritis - etiology</subject><subject>Glomerulonephritis, IGA - complications</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>IgA nephropathy</subject><subject>Immunofluorescence</subject><subject>Immunoglobulin A</subject><subject>Immunoglobulin G</subject><subject>Infection - complications</subject><subject>Kidney Glomerulus</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Proteinuria</subject><subject>Renal function</subject><subject>Retrospective Studies</subject><subject>Sclerosis</subject><subject>Urology</subject><issn>1342-1751</issn><issn>1437-7799</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9rHCEYh6W0NH_aD5BLEHrpxVZndBxzC0ubBgK9pGdx9XXXMKNbdQL77eN20wYCPam8z-_3Cg9CF4x-YZTKr4VRJiShbCRMDJzwN-iU8V4SKZV62-497wiTgp2gs1IeKKWjEuo9OulUw4dBnKLH-y1gD6YuGQoOEd9urolLc4gm1vb2YGtIkWSYTAWHN1OaIS9TirDb5lBDwS6UGqKt2Oc0H_L4zyztTN3ur7DBJcTNBMRCrJBxqYvbf0DvvJkKfHw-z9Gv79_uVz_I3c-b29X1HbFcsEq8p4bDSAfDvHIcVCcptbwT4KQUa877wQhFrZMenAVJeUtYOfRdz1Q_rvtz9PnYu8vp9wKl6jkUC9NkIqSl6I4ySYVifGzop1foQ1pybL87UANrrb1qFDtSNqdSMni9y2E2ea8Z1Qcp-ihFNyn6IEXzlrl8bl7WM7h_ib8WGtAdgdJGcQP5ZfX_W58AASGYYg</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Handa, Takaya</creator><creator>Kakita, Hiroko</creator><creator>Tateishi, Yu</creator><creator>Endo, Tomomi</creator><creator>Suzuki, Hiroyuki</creator><creator>Katayama, Toshiro</creator><creator>Tsukamoto, Tatsuo</creator><creator>Muso, Eri</creator><general>Springer Singapore</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study</title><author>Handa, Takaya ; Kakita, Hiroko ; Tateishi, Yu ; Endo, Tomomi ; Suzuki, Hiroyuki ; Katayama, Toshiro ; Tsukamoto, Tatsuo ; Muso, Eri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-ff0a4e806a1f9d4e92700c425ed775b4436a590cd7fedce704ff0c763231938b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Albumin</topic><topic>Antigen-antibody complexes</topic><topic>Biopsy</topic><topic>Creatinine</topic><topic>Epidermal growth factor receptors</topic><topic>Female</topic><topic>Glomerular filtration rate</topic><topic>Glomerulonephritis</topic><topic>Glomerulonephritis - etiology</topic><topic>Glomerulonephritis, IGA - complications</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>IgA nephropathy</topic><topic>Immunofluorescence</topic><topic>Immunoglobulin A</topic><topic>Immunoglobulin G</topic><topic>Infection - complications</topic><topic>Kidney Glomerulus</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Proteinuria</topic><topic>Renal function</topic><topic>Retrospective Studies</topic><topic>Sclerosis</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Handa, Takaya</creatorcontrib><creatorcontrib>Kakita, Hiroko</creatorcontrib><creatorcontrib>Tateishi, Yu</creatorcontrib><creatorcontrib>Endo, Tomomi</creatorcontrib><creatorcontrib>Suzuki, Hiroyuki</creatorcontrib><creatorcontrib>Katayama, Toshiro</creatorcontrib><creatorcontrib>Tsukamoto, Tatsuo</creatorcontrib><creatorcontrib>Muso, Eri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Handa, Takaya</au><au>Kakita, Hiroko</au><au>Tateishi, Yu</au><au>Endo, Tomomi</au><au>Suzuki, Hiroyuki</au><au>Katayama, Toshiro</au><au>Tsukamoto, Tatsuo</au><au>Muso, Eri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study</atitle><jtitle>Clinical and experimental nephrology</jtitle><stitle>Clin Exp Nephrol</stitle><addtitle>Clin Exp Nephrol</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>22</volume><issue>5</issue><spage>1116</spage><epage>1127</epage><pages>1116-1127</pages><issn>1342-1751</issn><eissn>1437-7799</eissn><abstract>Background
IgA-dominant infection-related glomerulonephritis (IgA-IRGN) is a unique form of IRGN, which needs to be distinguished from IgA nephropathy (IgAN).
Methods
Thirteen patients with IgA-IRGN (IgA-IRGN group) and 122 with IgAN (IgAN group) were selected from 1788 patients who underwent kidney biopsy between 2000 and 2015 in Kitano Hospital. Data selected included clinical and serological parameters; light and electron microscope findings; immunofluorescence findings; and prognostic parameters like renal and overall survival and creatinine increase by > 50%. In addition, a 26-patient IgAN cohort (matching-IgAN), matching with IgA-IRGN group with respect to age, sex, estimated glomerular filtration rate (eGFR), and proteinuria was segregated for comparison.
Results
Compared to IgAN group, IgA-IRGN group were older, had lower hemoglobin, higher CRP, lower eGFR, heavier proteinuria, lower serum albumin, and higher serum IgG and IgA levels (
p
< 0.05). Endocapillary hypercellularity, deposition of immune complexes along the glomerular capillary wall, and subendothelial and subepithelial electron dense deposits were more frequently observed (
p
< 0.05); and they were more susceptible to renal dysfunction and poorer prognosis. After propensity score-matching, serum albumin was significantly lower in the IgA-IRGN group. Significantly subendothelial and subepithelial deposits were frequently observed in this group. Matching-IgAN group showed relatively advanced sclerotic lesions with more global sclerosis and fibrous crescent.
Conclusion
Local inflammation involved glomerular capillary wall in IgA-IRGN, in contrast to relatively chronic and sclerotic renal lesion in IgAN, might result in poorer prognosis in former, even under indistinguishable condition of deteriorated renal function and proteinuria.</abstract><cop>Singapore</cop><pub>Springer Singapore</pub><pmid>29564665</pmid><doi>10.1007/s10157-018-1564-4</doi><tpages>12</tpages></addata></record> |
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| ispartof | Clinical and experimental nephrology, 2018-10, Vol.22 (5), p.1116-1127 |
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| subjects | Adult Aged Albumin Antigen-antibody complexes Biopsy Creatinine Epidermal growth factor receptors Female Glomerular filtration rate Glomerulonephritis Glomerulonephritis - etiology Glomerulonephritis, IGA - complications Hemoglobin Humans IgA nephropathy Immunofluorescence Immunoglobulin A Immunoglobulin G Infection - complications Kidney Glomerulus Male Medical prognosis Medicine Medicine & Public Health Middle Aged Nephrology Original Article Prognosis Proteinuria Renal function Retrospective Studies Sclerosis Urology |
| title | The features in IgA-dominant infection-related glomerulonephritis distinct from IgA nephropathy: a single-center study |
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