Cellular Uptake of Gold Nanoparticles Triggered by Host–Guest Interactions
We describe an approach to regulate the cellular uptake of small gold nanoparticles using supramolecular chemistry. The strategy relies on the functionalization of AuNPs with negatively charged pyranines, which largely hamper their penetration in cells. Cellular uptake can be activated in situ throu...
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| Veröffentlicht in: | Journal of the American Chemical Society 2018-04, Vol.140 (13), p.4469-4472 |
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| container_issue | 13 |
| container_start_page | 4469 |
| container_title | Journal of the American Chemical Society |
| container_volume | 140 |
| creator | Mosquera, Jesús Henriksen-Lacey, Malou García, Isabel Martínez-Calvo, Miguel Rodríguez, Jéssica Mascareñas, José L Liz-Marzán, Luis M |
| description | We describe an approach to regulate the cellular uptake of small gold nanoparticles using supramolecular chemistry. The strategy relies on the functionalization of AuNPs with negatively charged pyranines, which largely hamper their penetration in cells. Cellular uptake can be activated in situ through the addition of cationic covalent cages that specifically recognize the fluorescent pyranine dyes and counterbalance the negative charges. The high selectivity and reversibility of the host–guest recognition activates cellular uptake, even in protein-rich biological media, as well as its regulation by rational addition of either cage or pyranine. |
| doi_str_mv | 10.1021/jacs.7b12505 |
| format | Article |
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| title | Cellular Uptake of Gold Nanoparticles Triggered by Host–Guest Interactions |
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