Dynamics of chromatin marks and the role of JMJD3 during pancreatic endocrine cell fate commitment

Pancreatic endocrine lineages are derived from pancreatic progenitors that undergo a cell fate transition requiring a switch from low to high Ngn3 expression. However, the underlying chromatin regulatory mechanisms are unclear. Here, we performed epigenomic analysis of gene regulatory loci featuring...

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Veröffentlicht in:	Development (Cambridge) 2018-03, Vol.145 (6), p.dev163162-dev163162
Hauptverfasser:	Yu, Xin-Xin, Qiu, Wei-Lin, Yang, Liu, Li, Lin-Chen, Zhang, Yu-Wei, Xu, Cheng-Ran
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell fate Chromatin Clonal deletion Enhancers Gene expression Pancreas Ribonucleic acid RNA Transcription activation Transcription factors
Online-Zugang:	Volltext
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