Adamantane amine-linked chloroquinoline derivatives as chloroquine resistance modulating agents in Plasmodium falciparum

[Display omitted] Previously we have shown that pentacycloundecylamine-chloroquinoline (PCU-CQ) conjugates possess significant chemosensitizing abilities and can circumvent the resistance associated with chloroquine (CQ) resistant plasmodia. In order to further explore structurally related polycycli...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-05, Vol.28 (8), p.1287-1291
Hauptverfasser:	Yvette, Opute M., Malan, Sarel F., Taylor, Dale, Kapp, Erika, Joubert, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Adamantane - analogs & derivatives Adamantane - chemical synthesis Adamantane - chemistry Adamantane - pharmacology Adamantanes Aminoquinolines - chemical synthesis Aminoquinolines - chemistry Aminoquinolines - pharmacology Aminoquinolines - toxicity Animals Antimalarials - chemical synthesis Antimalarials - chemistry Antimalarials - pharmacology Antimalarials - toxicity Chemosensitizers CHO Cells Cricetulus Drug Resistance, Microbial - drug effects Erythrocytes - microbiology Humans Inhibitory Concentration 50 Molecular Structure Plasmodium falciparum Plasmodium falciparum - drug effects Resistance reversal agents
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