Partial Nephrectomy for Nephroblastoma: A National Cancer Data Base Review
Standard of care for unilateral nephroblastoma includes total nephrectomy (TN) with nodal sampling. We sought to compare the outcomes of TN and partial nephrectomy (PN). We performed a retrospective cohort study of TN and PN for nephroblastoma using the National Cancer Data Base. The outcomes includ...
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| Veröffentlicht in: | The American surgeon 2018-03, Vol.84 (3), p.338-343 |
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| creator | Richards, Morgan K. Goldin, Adam B. Ehrlich, Peter F. Beierle, Elizabeth A. Doski, John J. Goldfarb, Melanie Langer, Monica Nuchtern, Jed G. Vasudevan, Sanjeev Gow, Kenneth W. |
| description | Standard of care for unilateral nephroblastoma includes total nephrectomy (TN) with nodal sampling. We sought to compare the outcomes of TN and partial nephrectomy (PN). We performed a retrospective cohort study of TN and PN for nephroblastoma using the National Cancer Data Base. The outcomes included nodal sampling frequency, margin status, and survival. Categorical and continuous data were evaluated with χ2 and t tests, respectively (P < 0.05). Generalized linear models evaluated nodal sampling and margin status. Cox regression compared survival. In total, 235 patients underwent PN and 3572 had TN. TN patients were 50 per cent more likely to undergo nodal sampling (RR: 1.47, 95% CI 1.30–1.66). There was no difference in margin status (RR: 0.91, 95% CI 0.65–1.28) or overall survival (HR 1.57; 95% CI 0.78–3.19). This study reports the largest review of patients with PN for unilateral nephroblastoma. PN patients had less nodal sampling but similar margin involvement and overall survival. |
| doi_str_mv | 10.1177/000313481808400315 |
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We sought to compare the outcomes of TN and partial nephrectomy (PN). We performed a retrospective cohort study of TN and PN for nephroblastoma using the National Cancer Data Base. The outcomes included nodal sampling frequency, margin status, and survival. Categorical and continuous data were evaluated with χ2 and t tests, respectively (P < 0.05). Generalized linear models evaluated nodal sampling and margin status. Cox regression compared survival. In total, 235 patients underwent PN and 3572 had TN. TN patients were 50 per cent more likely to undergo nodal sampling (RR: 1.47, 95% CI 1.30–1.66). There was no difference in margin status (RR: 0.91, 95% CI 0.65–1.28) or overall survival (HR 1.57; 95% CI 0.78–3.19). This study reports the largest review of patients with PN for unilateral nephroblastoma. PN patients had less nodal sampling but similar margin involvement and overall survival.</description><identifier>ISSN: 0003-1348</identifier><identifier>EISSN: 1555-9823</identifier><identifier>DOI: 10.1177/000313481808400315</identifier><identifier>PMID: 29559046</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Cancer ; Cancer therapies ; Chemotherapy ; Children & youth ; Data bases ; Generalized linear models ; Histology ; Lymphatic system ; Nephrectomy ; Oncology ; Patients ; Pediatrics ; Quality standards ; Sampling ; Statistical models ; Surgery ; Surgical outcomes ; Survival ; Tumors ; Urology</subject><ispartof>The American surgeon, 2018-03, Vol.84 (3), p.338-343</ispartof><rights>2018 Southeastern Surgical Congress</rights><rights>Copyright Southeastern Surgical Congress Mar 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-b0007b5b36fb6a5bdd5f77b81248463daa1098563b026259acbd4ca53cd0e3913</citedby><cites>FETCH-LOGICAL-c415t-b0007b5b36fb6a5bdd5f77b81248463daa1098563b026259acbd4ca53cd0e3913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/000313481808400315$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/000313481808400315$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>315,781,785,21823,27928,27929,43625,43626</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29559046$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Richards, Morgan K.</creatorcontrib><creatorcontrib>Goldin, Adam B.</creatorcontrib><creatorcontrib>Ehrlich, Peter F.</creatorcontrib><creatorcontrib>Beierle, Elizabeth A.</creatorcontrib><creatorcontrib>Doski, John J.</creatorcontrib><creatorcontrib>Goldfarb, Melanie</creatorcontrib><creatorcontrib>Langer, Monica</creatorcontrib><creatorcontrib>Nuchtern, Jed G.</creatorcontrib><creatorcontrib>Vasudevan, Sanjeev</creatorcontrib><creatorcontrib>Gow, Kenneth W.</creatorcontrib><title>Partial Nephrectomy for Nephroblastoma: A National Cancer Data Base Review</title><title>The American surgeon</title><addtitle>Am Surg</addtitle><description>Standard of care for unilateral nephroblastoma includes total nephrectomy (TN) with nodal sampling. We sought to compare the outcomes of TN and partial nephrectomy (PN). We performed a retrospective cohort study of TN and PN for nephroblastoma using the National Cancer Data Base. The outcomes included nodal sampling frequency, margin status, and survival. Categorical and continuous data were evaluated with χ2 and t tests, respectively (P < 0.05). Generalized linear models evaluated nodal sampling and margin status. Cox regression compared survival. In total, 235 patients underwent PN and 3572 had TN. TN patients were 50 per cent more likely to undergo nodal sampling (RR: 1.47, 95% CI 1.30–1.66). There was no difference in margin status (RR: 0.91, 95% CI 0.65–1.28) or overall survival (HR 1.57; 95% CI 0.78–3.19). This study reports the largest review of patients with PN for unilateral nephroblastoma. PN patients had less nodal sampling but similar margin involvement and overall survival.</description><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemotherapy</subject><subject>Children & youth</subject><subject>Data bases</subject><subject>Generalized linear models</subject><subject>Histology</subject><subject>Lymphatic system</subject><subject>Nephrectomy</subject><subject>Oncology</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Quality standards</subject><subject>Sampling</subject><subject>Statistical models</subject><subject>Surgery</subject><subject>Surgical 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We sought to compare the outcomes of TN and partial nephrectomy (PN). We performed a retrospective cohort study of TN and PN for nephroblastoma using the National Cancer Data Base. The outcomes included nodal sampling frequency, margin status, and survival. Categorical and continuous data were evaluated with χ2 and t tests, respectively (P < 0.05). Generalized linear models evaluated nodal sampling and margin status. Cox regression compared survival. In total, 235 patients underwent PN and 3572 had TN. TN patients were 50 per cent more likely to undergo nodal sampling (RR: 1.47, 95% CI 1.30–1.66). There was no difference in margin status (RR: 0.91, 95% CI 0.65–1.28) or overall survival (HR 1.57; 95% CI 0.78–3.19). This study reports the largest review of patients with PN for unilateral nephroblastoma. 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| subjects | Cancer Cancer therapies Chemotherapy Children & youth Data bases Generalized linear models Histology Lymphatic system Nephrectomy Oncology Patients Pediatrics Quality standards Sampling Statistical models Surgery Surgical outcomes Survival Tumors Urology |
| title | Partial Nephrectomy for Nephroblastoma: A National Cancer Data Base Review |
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