Toxicity assessment of the puffer fish Lagocephalus lagocephalus from the Tunisian coast
This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish Lagocephalus lagocephalus collected along the Tunisian coast. Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of L. lagocephalus. Co...
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| Veröffentlicht in: | Comptes rendus. Biologies 2008-08, Vol.331 (8), p.611-616 |
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| description | This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish
Lagocephalus lagocephalus collected along the Tunisian coast.
Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of
L. lagocephalus. Control rats received injections of NaCl (0.9%). No mortality and no evident signs of neurotoxicity were recorded in treated rats. Conversely, treatment led to: (1) diarrhoea and body and organ (liver, kidney) weights loss; (2) oxidative stress evidenced by an increase in lipid peroxidation (TBARS) and conversely a decrease in antioxidant enzyme activities (SOD, catalase, GSH-Px) in tissues (blood cells, liver, kidneys); (3) a decrease in alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in blood plasma.
To cite this article: M. Saoudi et al., C. R. Biologies 331 (2008).
Des extraits acides de chair ou de foie de poisson ont été injectés par voie intrapéritonéale à des rats
Wistar, pendant 10 jours. Ce traitement a entraîné chez les rats traités, par rapport aux rats témoins traités avec une solution de NaCl (0,9%) : (1) un ralentissement de la croissance, avec diminution du poids du corps et des organes (foie, reins), ainsi que des diarrhées ; (2) un stress oxydant mis en évidence par une augmentation de la peroxidation lipidique (TBARS) et une diminution d'activité des enzymes antioxydantes (SOD, catalase, GSH-Px) dans les cellules sanguines et les tissus hépatiques et rénaux ; (3) une diminution de l'activité enzymatique de l'alanine amino transferase (ALT) et de la phosphatase alcaline (ALP) plasmatiques. Aucun signe de neurotoxicité n'a été observé.
Pour citer cet article : M. Saoudi et al., C. R. Biologies 331 (2008). |
| doi_str_mv | 10.1016/j.crvi.2008.05.005 |
| format | Article |
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Lagocephalus lagocephalus collected along the Tunisian coast.
Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of
L. lagocephalus. Control rats received injections of NaCl (0.9%). No mortality and no evident signs of neurotoxicity were recorded in treated rats. Conversely, treatment led to: (1) diarrhoea and body and organ (liver, kidney) weights loss; (2) oxidative stress evidenced by an increase in lipid peroxidation (TBARS) and conversely a decrease in antioxidant enzyme activities (SOD, catalase, GSH-Px) in tissues (blood cells, liver, kidneys); (3) a decrease in alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in blood plasma.
To cite this article: M. Saoudi et al., C. R. Biologies 331 (2008).
Des extraits acides de chair ou de foie de poisson ont été injectés par voie intrapéritonéale à des rats
Wistar, pendant 10 jours. Ce traitement a entraîné chez les rats traités, par rapport aux rats témoins traités avec une solution de NaCl (0,9%) : (1) un ralentissement de la croissance, avec diminution du poids du corps et des organes (foie, reins), ainsi que des diarrhées ; (2) un stress oxydant mis en évidence par une augmentation de la peroxidation lipidique (TBARS) et une diminution d'activité des enzymes antioxydantes (SOD, catalase, GSH-Px) dans les cellules sanguines et les tissus hépatiques et rénaux ; (3) une diminution de l'activité enzymatique de l'alanine amino transferase (ALT) et de la phosphatase alcaline (ALP) plasmatiques. Aucun signe de neurotoxicité n'a été observé.
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Lagocephalus lagocephalus collected along the Tunisian coast.
Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of
L. lagocephalus. Control rats received injections of NaCl (0.9%). No mortality and no evident signs of neurotoxicity were recorded in treated rats. Conversely, treatment led to: (1) diarrhoea and body and organ (liver, kidney) weights loss; (2) oxidative stress evidenced by an increase in lipid peroxidation (TBARS) and conversely a decrease in antioxidant enzyme activities (SOD, catalase, GSH-Px) in tissues (blood cells, liver, kidneys); (3) a decrease in alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in blood plasma.
To cite this article: M. Saoudi et al., C. R. Biologies 331 (2008).
Des extraits acides de chair ou de foie de poisson ont été injectés par voie intrapéritonéale à des rats
Wistar, pendant 10 jours. Ce traitement a entraîné chez les rats traités, par rapport aux rats témoins traités avec une solution de NaCl (0,9%) : (1) un ralentissement de la croissance, avec diminution du poids du corps et des organes (foie, reins), ainsi que des diarrhées ; (2) un stress oxydant mis en évidence par une augmentation de la peroxidation lipidique (TBARS) et une diminution d'activité des enzymes antioxydantes (SOD, catalase, GSH-Px) dans les cellules sanguines et les tissus hépatiques et rénaux ; (3) une diminution de l'activité enzymatique de l'alanine amino transferase (ALT) et de la phosphatase alcaline (ALP) plasmatiques. Aucun signe de neurotoxicité n'a été observé.
Pour citer cet article : M. Saoudi et al., C. R. Biologies 331 (2008).</description><subject>Alanine Transaminase - blood</subject><subject>Animals</subject><subject>Antioxidant status</subject><subject>Aspartate Aminotransferases - blood</subject><subject>Biological and medical sciences</subject><subject>Blood Cells - drug effects</subject><subject>Blood Cells - enzymology</subject><subject>Catalase - metabolism</subject><subject>Erythrocytes - drug effects</subject><subject>Erythrocytes - enzymology</subject><subject>Food toxicology</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Hepatotoxicity</subject><subject>Hépatotoxicité</subject><subject>Kidney - drug effects</subject><subject>Kidney - enzymology</subject><subject>Lagocephalus</subject><subject>Lagocephalus lagocephalus</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Marine</subject><subject>Marine Toxins - toxicity</subject><subject>Medical sciences</subject><subject>Nephrotoxicity</subject><subject>Néphrotoxicité</subject><subject>Oxidative Stress - drug effects</subject><subject>Pisces</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Statut antioxydant</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Tetraodontidae</subject><subject>Tetraodontiformes - physiology</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Toxicology</subject><subject>Tunisia</subject><issn>1631-0691</issn><issn>1768-3238</issn><issn>1768-3238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2P1DAMhiMEYpeFP8AB9QK3FidpM4nEBa34kkbiMkjcojR1mIzaZojbFfvvyTAj4AQn29LzWvbD2HMODQeuXh8an-9iIwB0A10D0D1g13yjdC2F1A9LrySvQRl-xZ4QHaCETNc9ZldcK1DSwDX7uks_oo_LfeWIkGjCealSqJY9Vsc1BMxViLSvtu5b8njcu3Glavx7CDlNv_DdOkeKbq58crQ8ZY-CGwmfXeoN-_L-3e72Y739_OHT7dtt7VsDSy1BQzCyDb7vNyFI5TeS93zgzndBCjEoA2LTGa07rr0RPGDJGQOqb50RRt6wV-e9x5y-r0iLnSJ5HEc3Y1rJivJ0K_n_wYIoLTgvoDiDPieijMEec5xcvrcc7Em8PdiTeHsSb6GzRXwJvbhsX_sJhz-Ri-kCvLwAjrwbQ3azj_SbE9Aa0baicG_OHBZpdxGzJR9x9jjEjH6xQ4r_uuMnxKehCQ</recordid><startdate>20080801</startdate><enddate>20080801</enddate><creator>Saoudi, Mongi</creator><creator>Abdelmouleh, Abdelwaheb</creator><creator>Kammoun, Wassim</creator><creator>Ellouze, Feriel</creator><creator>Jamoussi, Kamel</creator><creator>El Feki, Abdelfattah</creator><general>Elsevier SAS</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7TN</scope><scope>F1W</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope></search><sort><creationdate>20080801</creationdate><title>Toxicity assessment of the puffer fish Lagocephalus lagocephalus from the Tunisian coast</title><author>Saoudi, Mongi ; 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Biologies</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saoudi, Mongi</au><au>Abdelmouleh, Abdelwaheb</au><au>Kammoun, Wassim</au><au>Ellouze, Feriel</au><au>Jamoussi, Kamel</au><au>El Feki, Abdelfattah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicity assessment of the puffer fish Lagocephalus lagocephalus from the Tunisian coast</atitle><jtitle>Comptes rendus. Biologies</jtitle><addtitle>C R Biol</addtitle><date>2008-08-01</date><risdate>2008</risdate><volume>331</volume><issue>8</issue><spage>611</spage><epage>616</epage><pages>611-616</pages><issn>1631-0691</issn><issn>1768-3238</issn><eissn>1768-3238</eissn><abstract>This study was undertaken to assess the risk of poisoning due to consumption of the puffer fish
Lagocephalus lagocephalus collected along the Tunisian coast.
Wistar rats were daily intraperitoneally injected, for 10 days, with acidic extracts of liver or flesh (muscles + skin) of
L. lagocephalus. Control rats received injections of NaCl (0.9%). No mortality and no evident signs of neurotoxicity were recorded in treated rats. Conversely, treatment led to: (1) diarrhoea and body and organ (liver, kidney) weights loss; (2) oxidative stress evidenced by an increase in lipid peroxidation (TBARS) and conversely a decrease in antioxidant enzyme activities (SOD, catalase, GSH-Px) in tissues (blood cells, liver, kidneys); (3) a decrease in alanine aminotransferase (ALT) and alkaline phosphatase (ALP) activities in blood plasma.
To cite this article: M. Saoudi et al., C. R. Biologies 331 (2008).
Des extraits acides de chair ou de foie de poisson ont été injectés par voie intrapéritonéale à des rats
Wistar, pendant 10 jours. Ce traitement a entraîné chez les rats traités, par rapport aux rats témoins traités avec une solution de NaCl (0,9%) : (1) un ralentissement de la croissance, avec diminution du poids du corps et des organes (foie, reins), ainsi que des diarrhées ; (2) un stress oxydant mis en évidence par une augmentation de la peroxidation lipidique (TBARS) et une diminution d'activité des enzymes antioxydantes (SOD, catalase, GSH-Px) dans les cellules sanguines et les tissus hépatiques et rénaux ; (3) une diminution de l'activité enzymatique de l'alanine amino transferase (ALT) et de la phosphatase alcaline (ALP) plasmatiques. Aucun signe de neurotoxicité n'a été observé.
Pour citer cet article : M. Saoudi et al., C. R. Biologies 331 (2008).</abstract><cop>Paris</cop><pub>Elsevier SAS</pub><pmid>18606390</pmid><doi>10.1016/j.crvi.2008.05.005</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Comptes rendus. Biologies, 2008-08, Vol.331 (8), p.611-616 |
| issn | 1631-0691 1768-3238 1768-3238 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Alanine Transaminase - blood Animals Antioxidant status Aspartate Aminotransferases - blood Biological and medical sciences Blood Cells - drug effects Blood Cells - enzymology Catalase - metabolism Erythrocytes - drug effects Erythrocytes - enzymology Food toxicology Glutathione Peroxidase - metabolism Hepatotoxicity Hépatotoxicité Kidney - drug effects Kidney - enzymology Lagocephalus Lagocephalus lagocephalus Lipid Peroxidation - drug effects Liver - drug effects Liver - enzymology Male Marine Marine Toxins - toxicity Medical sciences Nephrotoxicity Néphrotoxicité Oxidative Stress - drug effects Pisces Rats Rats, Wistar Statut antioxydant Superoxide Dismutase - metabolism Tetraodontidae Tetraodontiformes - physiology Thiobarbituric Acid Reactive Substances - metabolism Toxicology Tunisia |
| title | Toxicity assessment of the puffer fish Lagocephalus lagocephalus from the Tunisian coast |
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