Response of integrated biomarkers of fish ( Lateolabrax japonicus) exposed to benzo[a]pyrene and sodium dodecylbenzene sulfonate
Fish Lateolabrax japonicus were exposed to 0.1 and 1 mg/L of anion surfactant sodium dodecylbenzene sulfonate (SDBS) and to 2 and 20 μg/L of benzo[a]pyrene (B[a]P) for 6, 12, and 18 days, with control and solvent control groups. Liver antioxidant enzymes, including superoxide dismutase (SOD), catala...
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Veröffentlicht in: | Ecotoxicology and environmental safety 2006-10, Vol.65 (2), p.230-236 |
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Sprache: | eng |
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Zusammenfassung: | Fish
Lateolabrax japonicus were exposed to 0.1 and 1
mg/L of anion surfactant sodium dodecylbenzene sulfonate (SDBS) and to 2 and 20
μg/L of benzo[a]pyrene (B[a]P) for 6, 12, and 18 days, with control and solvent control groups. Liver antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), and glutathione
S-transferase (GST), were determined; brain acetylcholinesterase (AChE) and liver inducible nitric oxide synthase (iNOS) activities were also measured. The results indicated that (1)
L. japonicus avoided oxidative damage through antioxidant systems; (2) SOD, GPx, and GSH were induced, and GST was inhibited and then induced by B[a]P exposure; and (3) CAT, GPx, and AChE were induced while iNOS was inhibited, and GST was induced and then inhibited by SDBS stress in experimental period. |
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ISSN: | 0147-6513 1090-2414 |
DOI: | 10.1016/j.ecoenv.2005.08.002 |