Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis
This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs. Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000–February 2017 inclusive) using the keywords ‘osteopo...
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| Veröffentlicht in: | Bone (New York, N.Y.) N.Y.), 2018-06, Vol.111, p.92-100 |
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| creator | Wu, Chih-Hsing Tu, Shih-Te Chang, Yin-Fan Chan, Ding-Cheng Chien, Jui-Teng Lin, Chih-Hsueh Singh, Sonal Dasari, Manikanta Chen, Jung-Fu Tsai, Keh-Sung |
| description | This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs.
Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000–February 2017 inclusive) using the keywords ‘osteoporosis’, ‘fractures’, ‘liaison’, and ‘service’ to identify randomised controlled trials and observational studies of patients aged ≥50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures, and mortality due to osteoporosis treatment.
A total of 159 publications were identified for the systematic literature review; 74 controlled studies (16 RCTs; 58 observational studies) were included in the meta-analysis. Overall, 41 of 58 observational studies and 12 of 16 RCTs were considered of high quality. Compared with patients receiving usual care (or those in the control arm), patients receiving care from an FLS program had higher rates of BMD testing (48.0% vs 23.5%) and treatment initiation (38.0% vs 17.2%) and greater adherence (57.0% vs 34.1%). Unweighted average rates of re-fracture were 13.4% among patients in the control arm and 6.4% in the FLS arm. Unweighted average rates of mortality were 15.8% in the control arm and 10.4% in the FLS arm. Meta-analysis revealed significant FLS-associated improvements in all outcomes versus non-FLS controls, with BMD testing increased by 24 percentage points (95% confidence interval [CI] 0.18–0.29), 20 percentage points for treatment rates (95% CI 0.16–0.25), and 22 percentage points for adherence (95% CI 0.13–0.31) and absolute risk of re-fracture reduced by five percentage points (95% CI –0.08 to −0.03) and mortality reduced by three percentage points (95% CI –0.05 to −0.01).
FLS programs improved outcomes of osteoporosis-related fractures, with significant increases in BMD testing, treatment initiation, and adherence to treatment and reductions in re-fracture incidence and mortality.
•FLS programs improve outcomes of osteoporosis-related fractures.•As FLS programs improve over time, patient outcomes will improve accordingly.•FLS play a significant role in reducing the disease burden of osteoporosis. |
| doi_str_mv | 10.1016/j.bone.2018.03.018 |
| format | Article |
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Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000–February 2017 inclusive) using the keywords ‘osteoporosis’, ‘fractures’, ‘liaison’, and ‘service’ to identify randomised controlled trials and observational studies of patients aged ≥50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures, and mortality due to osteoporosis treatment.
A total of 159 publications were identified for the systematic literature review; 74 controlled studies (16 RCTs; 58 observational studies) were included in the meta-analysis. Overall, 41 of 58 observational studies and 12 of 16 RCTs were considered of high quality. Compared with patients receiving usual care (or those in the control arm), patients receiving care from an FLS program had higher rates of BMD testing (48.0% vs 23.5%) and treatment initiation (38.0% vs 17.2%) and greater adherence (57.0% vs 34.1%). Unweighted average rates of re-fracture were 13.4% among patients in the control arm and 6.4% in the FLS arm. Unweighted average rates of mortality were 15.8% in the control arm and 10.4% in the FLS arm. Meta-analysis revealed significant FLS-associated improvements in all outcomes versus non-FLS controls, with BMD testing increased by 24 percentage points (95% confidence interval [CI] 0.18–0.29), 20 percentage points for treatment rates (95% CI 0.16–0.25), and 22 percentage points for adherence (95% CI 0.13–0.31) and absolute risk of re-fracture reduced by five percentage points (95% CI –0.08 to −0.03) and mortality reduced by three percentage points (95% CI –0.05 to −0.01).
FLS programs improved outcomes of osteoporosis-related fractures, with significant increases in BMD testing, treatment initiation, and adherence to treatment and reductions in re-fracture incidence and mortality.
•FLS programs improve outcomes of osteoporosis-related fractures.•As FLS programs improve over time, patient outcomes will improve accordingly.•FLS play a significant role in reducing the disease burden of osteoporosis.</description><identifier>ISSN: 8756-3282</identifier><identifier>EISSN: 1873-2763</identifier><identifier>DOI: 10.1016/j.bone.2018.03.018</identifier><identifier>PMID: 29555309</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Bone Density ; Fracture liaison services (FLS) ; Humans ; Meta-analysis ; Middle Aged ; Observational Studies as Topic ; Osteoporosis ; Osteoporotic Fractures - mortality ; Osteoporotic Fractures - prevention & control ; Osteoporotic Fractures - therapy ; Outcomes ; Randomized Controlled Trials as Topic ; Re-fracture ; Secondary Prevention ; Treatment Outcome</subject><ispartof>Bone (New York, N.Y.), 2018-06, Vol.111, p.92-100</ispartof><rights>2018 The Authors</rights><rights>Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c400t-91d1645b0b99f1cb639bd848f2d2f9424efc6d931e591cceed335933de68f6833</citedby><cites>FETCH-LOGICAL-c400t-91d1645b0b99f1cb639bd848f2d2f9424efc6d931e591cceed335933de68f6833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S8756328218301376$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29555309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Chih-Hsing</creatorcontrib><creatorcontrib>Tu, Shih-Te</creatorcontrib><creatorcontrib>Chang, Yin-Fan</creatorcontrib><creatorcontrib>Chan, Ding-Cheng</creatorcontrib><creatorcontrib>Chien, Jui-Teng</creatorcontrib><creatorcontrib>Lin, Chih-Hsueh</creatorcontrib><creatorcontrib>Singh, Sonal</creatorcontrib><creatorcontrib>Dasari, Manikanta</creatorcontrib><creatorcontrib>Chen, Jung-Fu</creatorcontrib><creatorcontrib>Tsai, Keh-Sung</creatorcontrib><title>Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis</title><title>Bone (New York, N.Y.)</title><addtitle>Bone</addtitle><description>This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs.
Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000–February 2017 inclusive) using the keywords ‘osteoporosis’, ‘fractures’, ‘liaison’, and ‘service’ to identify randomised controlled trials and observational studies of patients aged ≥50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures, and mortality due to osteoporosis treatment.
A total of 159 publications were identified for the systematic literature review; 74 controlled studies (16 RCTs; 58 observational studies) were included in the meta-analysis. Overall, 41 of 58 observational studies and 12 of 16 RCTs were considered of high quality. Compared with patients receiving usual care (or those in the control arm), patients receiving care from an FLS program had higher rates of BMD testing (48.0% vs 23.5%) and treatment initiation (38.0% vs 17.2%) and greater adherence (57.0% vs 34.1%). Unweighted average rates of re-fracture were 13.4% among patients in the control arm and 6.4% in the FLS arm. Unweighted average rates of mortality were 15.8% in the control arm and 10.4% in the FLS arm. Meta-analysis revealed significant FLS-associated improvements in all outcomes versus non-FLS controls, with BMD testing increased by 24 percentage points (95% confidence interval [CI] 0.18–0.29), 20 percentage points for treatment rates (95% CI 0.16–0.25), and 22 percentage points for adherence (95% CI 0.13–0.31) and absolute risk of re-fracture reduced by five percentage points (95% CI –0.08 to −0.03) and mortality reduced by three percentage points (95% CI –0.05 to −0.01).
FLS programs improved outcomes of osteoporosis-related fractures, with significant increases in BMD testing, treatment initiation, and adherence to treatment and reductions in re-fracture incidence and mortality.
•FLS programs improve outcomes of osteoporosis-related fractures.•As FLS programs improve over time, patient outcomes will improve accordingly.•FLS play a significant role in reducing the disease burden of osteoporosis.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Density</subject><subject>Fracture liaison services (FLS)</subject><subject>Humans</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Observational Studies as Topic</subject><subject>Osteoporosis</subject><subject>Osteoporotic Fractures - mortality</subject><subject>Osteoporotic Fractures - prevention & control</subject><subject>Osteoporotic Fractures - therapy</subject><subject>Outcomes</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Re-fracture</subject><subject>Secondary Prevention</subject><subject>Treatment Outcome</subject><issn>8756-3282</issn><issn>1873-2763</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EokPhBVggL9kk-CfJ2IhNVVFaqRIbWFuOfS08SuLBdqaad-ChucMMLFkdyTrns865hLzlrOWMDx927ZgWaAXjqmWyRXlGNlxtZSO2g3xONmrbD40USlyRV6XsGGNSb_lLciV03_eS6Q35dZetq2sGOkUbS1pogXyIDgqN8z6nA9C0VpdmfEiB7m2NsNRCn2L9QVOpkPYppxJLk2GyFTwNF2D5SG9oOaJlxpBDfoVs_3yV4RDhidrF0xmqbexipyMyXpMXwU4F3lz0mny_-_zt9r55_Prl4fbmsXEdY7XR3POh60c2ah24GwepR686FYQXQXeig-AGryWHXnPnALyUvZbSw6DCoKS8Ju_PXCz4c4VSzRyLg2myC6S1GFy0V7ibVGgVZ6vDliVDMPscZ5uPhjNzuoLZmdMVThllmDQoGHp34a_jDP5f5O_saPh0NgC2xC2yKQ53deBjBleNT_F__N9sop0H</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Wu, Chih-Hsing</creator><creator>Tu, Shih-Te</creator><creator>Chang, Yin-Fan</creator><creator>Chan, Ding-Cheng</creator><creator>Chien, Jui-Teng</creator><creator>Lin, Chih-Hsueh</creator><creator>Singh, Sonal</creator><creator>Dasari, Manikanta</creator><creator>Chen, Jung-Fu</creator><creator>Tsai, Keh-Sung</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201806</creationdate><title>Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis</title><author>Wu, Chih-Hsing ; Tu, Shih-Te ; Chang, Yin-Fan ; Chan, Ding-Cheng ; Chien, Jui-Teng ; Lin, Chih-Hsueh ; Singh, Sonal ; Dasari, Manikanta ; Chen, Jung-Fu ; Tsai, Keh-Sung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c400t-91d1645b0b99f1cb639bd848f2d2f9424efc6d931e591cceed335933de68f6833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Density</topic><topic>Fracture liaison services (FLS)</topic><topic>Humans</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Observational Studies as Topic</topic><topic>Osteoporosis</topic><topic>Osteoporotic Fractures - mortality</topic><topic>Osteoporotic Fractures - prevention & control</topic><topic>Osteoporotic Fractures - therapy</topic><topic>Outcomes</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Re-fracture</topic><topic>Secondary Prevention</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Chih-Hsing</creatorcontrib><creatorcontrib>Tu, Shih-Te</creatorcontrib><creatorcontrib>Chang, Yin-Fan</creatorcontrib><creatorcontrib>Chan, Ding-Cheng</creatorcontrib><creatorcontrib>Chien, Jui-Teng</creatorcontrib><creatorcontrib>Lin, Chih-Hsueh</creatorcontrib><creatorcontrib>Singh, Sonal</creatorcontrib><creatorcontrib>Dasari, Manikanta</creatorcontrib><creatorcontrib>Chen, Jung-Fu</creatorcontrib><creatorcontrib>Tsai, Keh-Sung</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bone (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Chih-Hsing</au><au>Tu, Shih-Te</au><au>Chang, Yin-Fan</au><au>Chan, Ding-Cheng</au><au>Chien, Jui-Teng</au><au>Lin, Chih-Hsueh</au><au>Singh, Sonal</au><au>Dasari, Manikanta</au><au>Chen, Jung-Fu</au><au>Tsai, Keh-Sung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis</atitle><jtitle>Bone (New York, N.Y.)</jtitle><addtitle>Bone</addtitle><date>2018-06</date><risdate>2018</risdate><volume>111</volume><spage>92</spage><epage>100</epage><pages>92-100</pages><issn>8756-3282</issn><eissn>1873-2763</eissn><abstract>This systematic review and meta-analysis evaluated the outcomes of patients with osteoporosis-related fractures managed through fracture liaison services (FLS) programs.
Medline, PubMed, EMBASE, and the Cochrane Library were searched (January 2000–February 2017 inclusive) using the keywords ‘osteoporosis’, ‘fractures’, ‘liaison’, and ‘service’ to identify randomised controlled trials and observational studies of patients aged ≥50years with osteoporosis-related fractures in hospital, clinic, community, or home-based settings who were managed using FLS. Risk of bias was assessed at outcome level. Meta-analysis followed a random-effects and fixed-effects model. Outcomes of interest were incidence of bone mineral density (BMD) testing, treatment initiation, adherence, re-fractures, and mortality due to osteoporosis treatment.
A total of 159 publications were identified for the systematic literature review; 74 controlled studies (16 RCTs; 58 observational studies) were included in the meta-analysis. Overall, 41 of 58 observational studies and 12 of 16 RCTs were considered of high quality. Compared with patients receiving usual care (or those in the control arm), patients receiving care from an FLS program had higher rates of BMD testing (48.0% vs 23.5%) and treatment initiation (38.0% vs 17.2%) and greater adherence (57.0% vs 34.1%). Unweighted average rates of re-fracture were 13.4% among patients in the control arm and 6.4% in the FLS arm. Unweighted average rates of mortality were 15.8% in the control arm and 10.4% in the FLS arm. Meta-analysis revealed significant FLS-associated improvements in all outcomes versus non-FLS controls, with BMD testing increased by 24 percentage points (95% confidence interval [CI] 0.18–0.29), 20 percentage points for treatment rates (95% CI 0.16–0.25), and 22 percentage points for adherence (95% CI 0.13–0.31) and absolute risk of re-fracture reduced by five percentage points (95% CI –0.08 to −0.03) and mortality reduced by three percentage points (95% CI –0.05 to −0.01).
FLS programs improved outcomes of osteoporosis-related fractures, with significant increases in BMD testing, treatment initiation, and adherence to treatment and reductions in re-fracture incidence and mortality.
•FLS programs improve outcomes of osteoporosis-related fractures.•As FLS programs improve over time, patient outcomes will improve accordingly.•FLS play a significant role in reducing the disease burden of osteoporosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>29555309</pmid><doi>10.1016/j.bone.2018.03.018</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Bone Density Fracture liaison services (FLS) Humans Meta-analysis Middle Aged Observational Studies as Topic Osteoporosis Osteoporotic Fractures - mortality Osteoporotic Fractures - prevention & control Osteoporotic Fractures - therapy Outcomes Randomized Controlled Trials as Topic Re-fracture Secondary Prevention Treatment Outcome |
| title | Fracture liaison services improve outcomes of patients with osteoporosis-related fractures: A systematic literature review and meta-analysis |
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