Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system. The primary location of GISTs is mainly the gastrointestinal system. Clinical symptoms are nonspecific and mainly depend on the location and size of the tumor. The aim of this study was to conduct...
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| Veröffentlicht in: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2018-05, Vol.27 (5), p.667-671 |
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| container_title | Advances in clinical and experimental medicine : official organ Wroclaw Medical University |
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| creator | Janczak, Dariusz Rać, Jacek Pawłowski, Wiktor Dorobisz, Tadeusz Ziomek, Agnieszka Janczak, Dawid Leśniak, Michał Chabowski, Mariusz |
| description | Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system. The primary location of GISTs is mainly the gastrointestinal system. Clinical symptoms are nonspecific and mainly depend on the location and size of the tumor.
The aim of this study was to conduct a clinical and pathological analysis of 18 cases of GISTs from the medical records of the Department of Surgery at the 4th Military Teaching Hospital in Wrocław, Poland.
The medical records were of women and men at the age of 36-84 years who were treated in the Surgical Clinic. The medical data that was gathered included clinical records, histopathological results and the type of surgical treatment. The study also encompassed the anatomical location and size of the tumor as well as microscopic examination of the tumor.
In most cases, GISTs were located in the stomach. The most common symptoms were stomachaches and signs of bleeding into the digestive system. Usually, the tumor presented a diameter of |
| doi_str_mv | 10.17219/acem/68718 |
| format | Article |
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The aim of this study was to conduct a clinical and pathological analysis of 18 cases of GISTs from the medical records of the Department of Surgery at the 4th Military Teaching Hospital in Wrocław, Poland.
The medical records were of women and men at the age of 36-84 years who were treated in the Surgical Clinic. The medical data that was gathered included clinical records, histopathological results and the type of surgical treatment. The study also encompassed the anatomical location and size of the tumor as well as microscopic examination of the tumor.
In most cases, GISTs were located in the stomach. The most common symptoms were stomachaches and signs of bleeding into the digestive system. Usually, the tumor presented a diameter of <5 cm and a low grade of malignancy. Out of 18 patients, 16 were treated with laparoscopic resection, whereas in the remaining 2 cases, multiorgan resections were carried out, because the tumor was locally advanced.
It is essential to distinguish stromal tumors from other mesenchymal tumors, since GISTs are among the cancers that have a high risk of malignant progression. The conditions for successful treatment are a properly established histopathological diagnosis, accompanied by immunohistochemical tests for CD117, and a combination of antibodies for a differential diagnosis of other mesenchymal tumors.</description><identifier>ISSN: 1899-5276</identifier><identifier>DOI: 10.17219/acem/68718</identifier><identifier>PMID: 29558033</identifier><language>eng</language><publisher>Poland</publisher><subject>Abdominal Pain - etiology ; Adult ; Aged ; Aged, 80 and over ; Female ; Gastrointestinal Hemorrhage - etiology ; Gastrointestinal Stromal Tumors - pathology ; Gastrointestinal Stromal Tumors - surgery ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Poland ; Proto-Oncogene Proteins c-kit ; Stomach Neoplasms - pathology ; Stomach Neoplasms - surgery ; Treatment Outcome</subject><ispartof>Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2018-05, Vol.27 (5), p.667-671</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-807baeb8e211fdd34e6971884a44adeceb54f10c6d273b0c71aef54bdb975cdf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29558033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janczak, Dariusz</creatorcontrib><creatorcontrib>Rać, Jacek</creatorcontrib><creatorcontrib>Pawłowski, Wiktor</creatorcontrib><creatorcontrib>Dorobisz, Tadeusz</creatorcontrib><creatorcontrib>Ziomek, Agnieszka</creatorcontrib><creatorcontrib>Janczak, Dawid</creatorcontrib><creatorcontrib>Leśniak, Michał</creatorcontrib><creatorcontrib>Chabowski, Mariusz</creatorcontrib><title>Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department</title><title>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</title><addtitle>Adv Clin Exp Med</addtitle><description>Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system. The primary location of GISTs is mainly the gastrointestinal system. Clinical symptoms are nonspecific and mainly depend on the location and size of the tumor.
The aim of this study was to conduct a clinical and pathological analysis of 18 cases of GISTs from the medical records of the Department of Surgery at the 4th Military Teaching Hospital in Wrocław, Poland.
The medical records were of women and men at the age of 36-84 years who were treated in the Surgical Clinic. The medical data that was gathered included clinical records, histopathological results and the type of surgical treatment. The study also encompassed the anatomical location and size of the tumor as well as microscopic examination of the tumor.
In most cases, GISTs were located in the stomach. The most common symptoms were stomachaches and signs of bleeding into the digestive system. Usually, the tumor presented a diameter of <5 cm and a low grade of malignancy. Out of 18 patients, 16 were treated with laparoscopic resection, whereas in the remaining 2 cases, multiorgan resections were carried out, because the tumor was locally advanced.
It is essential to distinguish stromal tumors from other mesenchymal tumors, since GISTs are among the cancers that have a high risk of malignant progression. The conditions for successful treatment are a properly established histopathological diagnosis, accompanied by immunohistochemical tests for CD117, and a combination of antibodies for a differential diagnosis of other mesenchymal tumors.</description><subject>Abdominal Pain - etiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Gastrointestinal Hemorrhage - etiology</subject><subject>Gastrointestinal Stromal Tumors - pathology</subject><subject>Gastrointestinal Stromal Tumors - surgery</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Poland</subject><subject>Proto-Oncogene Proteins c-kit</subject><subject>Stomach Neoplasms - pathology</subject><subject>Stomach Neoplasms - surgery</subject><subject>Treatment Outcome</subject><issn>1899-5276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLxDAUhbNQnGGclXvJUpA6ebaJu2HwBSNudF3S5LZE-jJpwfn3ts7o3RwufOfAOQhdUXJHM0b1xlhoNqnKqDpDS6q0TiTL0gVax_hJphOaaSIu0IJpKRXhfInsq2lNBQ20A-5KXJk4hM63A8TBt6bG89tMOoxNF-I93mJKkgOYgOG7h-ChtTAbDY6-rWrAcQyVt5PDQW_CMAdfovPS1BHWJ12hj8eH991zsn97etlt94nlLB0SRbLCQKGAUVo6xwWkeqqihBHCOLBQSFFSYlPHMl4Qm1EDpRSFK3QmrSv5Ct0cc_vQfY1Tg7zx0UJdmxa6MeaMUKk44zKd0NsjakMXY4Ay74NvTDjklOS_Y-bzmPnvmBN9fQoeiwbcP_s3I_8BXIhzpg</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Janczak, Dariusz</creator><creator>Rać, Jacek</creator><creator>Pawłowski, Wiktor</creator><creator>Dorobisz, Tadeusz</creator><creator>Ziomek, Agnieszka</creator><creator>Janczak, Dawid</creator><creator>Leśniak, Michał</creator><creator>Chabowski, Mariusz</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department</title><author>Janczak, Dariusz ; Rać, Jacek ; Pawłowski, Wiktor ; Dorobisz, Tadeusz ; Ziomek, Agnieszka ; Janczak, Dawid ; Leśniak, Michał ; Chabowski, Mariusz</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-807baeb8e211fdd34e6971884a44adeceb54f10c6d273b0c71aef54bdb975cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdominal Pain - etiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Gastrointestinal Hemorrhage - etiology</topic><topic>Gastrointestinal Stromal Tumors - pathology</topic><topic>Gastrointestinal Stromal Tumors - surgery</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Poland</topic><topic>Proto-Oncogene Proteins c-kit</topic><topic>Stomach Neoplasms - pathology</topic><topic>Stomach Neoplasms - surgery</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janczak, Dariusz</creatorcontrib><creatorcontrib>Rać, Jacek</creatorcontrib><creatorcontrib>Pawłowski, Wiktor</creatorcontrib><creatorcontrib>Dorobisz, Tadeusz</creatorcontrib><creatorcontrib>Ziomek, Agnieszka</creatorcontrib><creatorcontrib>Janczak, Dawid</creatorcontrib><creatorcontrib>Leśniak, Michał</creatorcontrib><creatorcontrib>Chabowski, Mariusz</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janczak, Dariusz</au><au>Rać, Jacek</au><au>Pawłowski, Wiktor</au><au>Dorobisz, Tadeusz</au><au>Ziomek, Agnieszka</au><au>Janczak, Dawid</au><au>Leśniak, Michał</au><au>Chabowski, Mariusz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department</atitle><jtitle>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</jtitle><addtitle>Adv Clin Exp Med</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>27</volume><issue>5</issue><spage>667</spage><epage>671</epage><pages>667-671</pages><issn>1899-5276</issn><abstract>Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive system. The primary location of GISTs is mainly the gastrointestinal system. Clinical symptoms are nonspecific and mainly depend on the location and size of the tumor.
The aim of this study was to conduct a clinical and pathological analysis of 18 cases of GISTs from the medical records of the Department of Surgery at the 4th Military Teaching Hospital in Wrocław, Poland.
The medical records were of women and men at the age of 36-84 years who were treated in the Surgical Clinic. The medical data that was gathered included clinical records, histopathological results and the type of surgical treatment. The study also encompassed the anatomical location and size of the tumor as well as microscopic examination of the tumor.
In most cases, GISTs were located in the stomach. The most common symptoms were stomachaches and signs of bleeding into the digestive system. Usually, the tumor presented a diameter of <5 cm and a low grade of malignancy. Out of 18 patients, 16 were treated with laparoscopic resection, whereas in the remaining 2 cases, multiorgan resections were carried out, because the tumor was locally advanced.
It is essential to distinguish stromal tumors from other mesenchymal tumors, since GISTs are among the cancers that have a high risk of malignant progression. The conditions for successful treatment are a properly established histopathological diagnosis, accompanied by immunohistochemical tests for CD117, and a combination of antibodies for a differential diagnosis of other mesenchymal tumors.</abstract><cop>Poland</cop><pmid>29558033</pmid><doi>10.17219/acem/68718</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Abdominal Pain - etiology Adult Aged Aged, 80 and over Female Gastrointestinal Hemorrhage - etiology Gastrointestinal Stromal Tumors - pathology Gastrointestinal Stromal Tumors - surgery Humans Immunohistochemistry Male Middle Aged Poland Proto-Oncogene Proteins c-kit Stomach Neoplasms - pathology Stomach Neoplasms - surgery Treatment Outcome |
| title | Management of gastrointestinal stromal tumors: A 10-year experience of a single surgical department |
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