Oxidants produced by methylglyoxal-modified collagen trigger ER stress and apoptosis in skin fibroblasts

Methylglyoxal (MG), a highly reactive dicarbonyl, interacts with proteins to form advanced glycation end products (AGEs). AGEs include a variety of compounds which were shown to have damaging potential and to accumulate in the course of different conditions such as diabetes mellitus and aging. After...

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Veröffentlicht in:	Free radical biology & medicine 2018-05, Vol.120, p.102-113
Hauptverfasser:	Nowotny, Kerstin, Castro, José Pedro, Hugo, Martín, Braune, Sabine, Weber, Daniela, Pignitter, Marc, Somoza, Veronika, Bornhorst, Julia, Schwerdtle, Tanja, Grune, Tilman
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycation end products Aging Aging - metabolism Animals Apoptosis Apoptosis - drug effects Apoptosis - physiology Collagen Collagen - drug effects Collagen - metabolism Endoplasmic Reticulum Stress - physiology ER stress Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Glycation End Products, Advanced - metabolism Humans Methylglyoxal Mice Mice, Inbred C57BL Oxidants - metabolism Pyruvaldehyde - metabolism Pyruvaldehyde - toxicity Redox homeostasis Skin
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