Myeloperoxidase in the inflamed colon: A novel target for treating inflammatory bowel disease

Inflammatory bowel disease (IBD) is a debilitating disorder involving inflammation of the gastrointestinal tract. The incidence of IBD is increasing worldwide. Immunological responses in the gastrointestinal (GI) tract to altered gut microbiota, mucosal injury and loss of intestinal epithelial cell...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2018-05, Vol.645, p.61-71
Hauptverfasser:	Chami, Belal, Martin, Nathan J.J., Dennis, Joanne M., Witting, Paul K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Colon Colon - drug effects Colon - enzymology Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use HOCl Humans Inflammation Inflammatory bowel disease (IBD) Inflammatory Bowel Diseases - drug therapy Inflammatory Bowel Diseases - enzymology Inflammatory Bowel Diseases - metabolism Map kinase Molecular Targeted Therapy - methods Myeloperoxidase Neutrophil Oxidation Peroxidase - antagonists & inhibitors Peroxidase - metabolism
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