Senescent human hematopoietic progenitors show elevated expression of transposable elements and inflammatory genes

•Senescent human hematopoietic stem and progenitor cells (s-HSPCs) show increased transposable element (TE) expression.•Percentage of circulating HSPCs does not increase with age.•TE expression may contribute to immune pathway activation in senescence. Genomic transposable elements (TEs) constitute...

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Veröffentlicht in:	Experimental hematology 2018-06, Vol.62, p.33-38.e6
Hauptverfasser:	Capone, Stephen, Connor, Kwasi M., Colombo, Anthony, Li, Xin, Triche, Tim J., Ramsingh, Giridharan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Cellular Senescence - genetics Cytokines - biosynthesis Cytokines - genetics DNA Transposable Elements - genetics Female Gene Expression Regulation - immunology Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Humans Inflammation Interferons - biosynthesis Interferons - genetics Male Middle Aged Molecular Mimicry - immunology Transcriptome Up-Regulation Young Adult
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