Spontaneous Glioblastoma Spheroid Infiltration of Early-Stage Cerebral Organoids Models Brain Tumor Invasion

Organoid methodology provides a platform for the ex vivo investigation of the cellular and molecular mechanisms underlying brain development and disease. The high-grade brain tumor glioblastoma multiforme (GBM) is considered a cancer of unmet clinical need, in part due to GBM cell infiltration into...

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Veröffentlicht in:	SLAS discovery 2018-09, Vol.23 (8), p.862-868
Hauptverfasser:	da Silva, Bárbara, Mathew, Ryan K., Polson, Euan S., Williams, Jennifer, Wurdak, Heiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Culture Techniques Cell Movement Fluorescent Antibody Technique Glioblastoma - metabolism Glioblastoma - pathology Humans Immunohistochemistry Neoplasm Invasiveness Neoplasm Staging Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Organoids
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