Metabolism and Anticancer Activity of the Curcumin Analogue, Dimethoxycurcumin

Purpose: The plant-derived compound curcumin has shown promising abilities as a cancer chemoprevention and chemotherapy agent in vitro and in vivo but exhibits poor bioavailability. Therefore, there is a need to investigate modified curcumin congeners for improved anticancer activity and pharmacokin...

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Veröffentlicht in:	Clinical cancer research 2007-02, Vol.13 (4), p.1269-1277
Hauptverfasser:	TAMVAKOPOULOS, Constantin, DIMAS, Konstantinos, SOFIANOS, Zacharias D, HATZIANTONIOU, Sophia, ZHIYONG HAN, LIU, Zhong-Li, WYCHE, James H, PANTAZIS, Panayotis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biological and medical sciences Cancer Cells Cell Growth Processes - drug effects Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Curcumin - analogs & derivatives Curcumin - metabolism Curcumin - pharmacology Curcumin - toxicity Curcumin Analogues Drug Metabolism Drug Screening Assays, Antitumor Drug Stability Female Flow Cytometry HCT116 Cells Humans Male Mass Spectrometry Medical sciences Mice Microsomes, Liver - metabolism Pharmacology. Drug treatments
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