Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study
Incidence and determinants of affective disorders among adults with intellectual disabilities are unknown.AimsTo investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports. Prospective cohort study measuring mental ill health of adults...
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| Veröffentlicht in: | British journal of psychiatry 2018-05, Vol.212 (5), p.295-300 |
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| creator | Cooper, Sally-Ann Smiley, Elita Allan, Linda Morrison, Jillian |
| description | Incidence and determinants of affective disorders among adults with intellectual disabilities are unknown.AimsTo investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports.
Prospective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years.
There was 70% cohort retention (n = 651). Despite high mood stabiliser use (22.4%), 2-year incident mania at 1.1% is higher than the general population; 0.3% for first episode (standardised incident ratio (SIR) = 41.5, or 52.7 excluding Down syndrome). For any bipolar episode the SIR was 2.0 (or 2.5 excluding Down syndrome). Depression incidence at 7.2% is similar to the general population (SIR = 1.2), suggesting more enduring/undertreatment given the higher prevalence. Problem behaviours (odds ratio (OR) = 2.3) and life events (OR = 1.3) predict incident unipolar depression.
Depression needs improved treatment. Mania has received remarkably little attention in this population, despite high prevalence and incidence (similar to schizophrenia), and given the importance of clinician awareness for accurate differential diagnosis from attention-deficit hyperactivity disorder and problem behaviours.Declaration of interestNone. |
| doi_str_mv | 10.1192/bjp.2018.12 |
| format | Article |
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Prospective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years.
There was 70% cohort retention (n = 651). Despite high mood stabiliser use (22.4%), 2-year incident mania at 1.1% is higher than the general population; 0.3% for first episode (standardised incident ratio (SIR) = 41.5, or 52.7 excluding Down syndrome). For any bipolar episode the SIR was 2.0 (or 2.5 excluding Down syndrome). Depression incidence at 7.2% is similar to the general population (SIR = 1.2), suggesting more enduring/undertreatment given the higher prevalence. Problem behaviours (odds ratio (OR) = 2.3) and life events (OR = 1.3) predict incident unipolar depression.
Depression needs improved treatment. Mania has received remarkably little attention in this population, despite high prevalence and incidence (similar to schizophrenia), and given the importance of clinician awareness for accurate differential diagnosis from attention-deficit hyperactivity disorder and problem behaviours.Declaration of interestNone.</description><identifier>ISSN: 0007-1250</identifier><identifier>EISSN: 1472-1465</identifier><identifier>DOI: 10.1192/bjp.2018.12</identifier><identifier>PMID: 29540250</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Adults ; Affective disorders ; Attention ; Attention deficit hyperactivity disorder ; Behavior problems ; Bipolar disorder ; Bipolar Disorder - epidemiology ; Cohort analysis ; Cohort Studies ; Comorbidity ; Depressive Disorder - epidemiology ; Developmental disabilities ; Differential diagnosis ; Down syndrome ; Down's syndrome ; Emotional disorders ; Epidemiology ; Female ; Humans ; Hyperactivity ; Incidence ; Intellectual disabilities ; Intellectual Disability - epidemiology ; Interviews ; Learning disabilities ; Life events ; Male ; Mania ; Medical diagnosis ; Mental depression ; Mental disorders ; Mental health ; Middle Aged ; Mood ; Population ; Psychiatrists ; Psychiatry ; Schizophrenia ; Scotland - epidemiology ; Treatment needs</subject><ispartof>British journal of psychiatry, 2018-05, Vol.212 (5), p.295-300</ispartof><rights>Copyright © The Royal College of Psychiatrists 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-922c60e614b02081db99361f2a177071cbf6634c32285faf39da7c9ca1195b3b3</citedby><cites>FETCH-LOGICAL-c392t-922c60e614b02081db99361f2a177071cbf6634c32285faf39da7c9ca1195b3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007125018000120/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,780,784,12845,27923,27924,30998,55627</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29540250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cooper, Sally-Ann</creatorcontrib><creatorcontrib>Smiley, Elita</creatorcontrib><creatorcontrib>Allan, Linda</creatorcontrib><creatorcontrib>Morrison, Jillian</creatorcontrib><title>Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study</title><title>British journal of psychiatry</title><addtitle>Br J Psychiatry</addtitle><description>Incidence and determinants of affective disorders among adults with intellectual disabilities are unknown.AimsTo investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports.
Prospective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years.
There was 70% cohort retention (n = 651). Despite high mood stabiliser use (22.4%), 2-year incident mania at 1.1% is higher than the general population; 0.3% for first episode (standardised incident ratio (SIR) = 41.5, or 52.7 excluding Down syndrome). For any bipolar episode the SIR was 2.0 (or 2.5 excluding Down syndrome). Depression incidence at 7.2% is similar to the general population (SIR = 1.2), suggesting more enduring/undertreatment given the higher prevalence. Problem behaviours (odds ratio (OR) = 2.3) and life events (OR = 1.3) predict incident unipolar depression.
Depression needs improved treatment. Mania has received remarkably little attention in this population, despite high prevalence and incidence (similar to schizophrenia), and given the importance of clinician awareness for accurate differential diagnosis from attention-deficit hyperactivity disorder and problem behaviours.Declaration of interestNone.</description><subject>Adult</subject><subject>Adults</subject><subject>Affective disorders</subject><subject>Attention</subject><subject>Attention deficit hyperactivity disorder</subject><subject>Behavior problems</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Depressive Disorder - epidemiology</subject><subject>Developmental disabilities</subject><subject>Differential diagnosis</subject><subject>Down syndrome</subject><subject>Down's syndrome</subject><subject>Emotional disorders</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Hyperactivity</subject><subject>Incidence</subject><subject>Intellectual disabilities</subject><subject>Intellectual Disability - epidemiology</subject><subject>Interviews</subject><subject>Learning disabilities</subject><subject>Life events</subject><subject>Male</subject><subject>Mania</subject><subject>Medical diagnosis</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Middle Aged</subject><subject>Mood</subject><subject>Population</subject><subject>Psychiatrists</subject><subject>Psychiatry</subject><subject>Schizophrenia</subject><subject>Scotland - epidemiology</subject><subject>Treatment needs</subject><issn>0007-1250</issn><issn>1472-1465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkc1P3DAQxS0EYreUU-_IEhekkq1nnI8NN4SAIiH10p4jf4X1KnGC7bSCvx5vCVSqONkz_unN8zxCvgBbAdT4TW7HFTJYrwD3yBLyCjPIy2KfLBljVQZYsAX5FMI2lTzH6pAssC5ylvpL8nznlNXGKUOHlk7OjkMnPBVOUznftRm9CcEO7vxvvxfOCmodFXrqYqB_bNykMpquMypOoqPaBiFtZ6M14YKOfghjerG_DVXDZvCRhjjpp8_koBVdMMfzeUR-3Vz_vPqe3f-4vbu6vM8UrzFmNaIqmSkhlwzZGrSsa15CiwKqilWgZFuWPFcccV20ouW1FpWqlUjLKSSX_IicveomI4-TCbHpbVDJrXBmmEKTdpdDXgDDhJ7-h26HybvkrkEEDmkEFon6-kqp9LPgTduM3vbCPzXAml0kTYpkJ7tuYKd5MmtOsjf6nX3LIAHZLCd66a1-MP-mfiT4AuEflmk</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Cooper, Sally-Ann</creator><creator>Smiley, Elita</creator><creator>Allan, Linda</creator><creator>Morrison, Jillian</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QJ</scope><scope>7TK</scope><scope>7XB</scope><scope>88G</scope><scope>88J</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HEHIP</scope><scope>M2M</scope><scope>M2O</scope><scope>M2R</scope><scope>M2S</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study</title><author>Cooper, Sally-Ann ; Smiley, Elita ; Allan, Linda ; Morrison, Jillian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-922c60e614b02081db99361f2a177071cbf6634c32285faf39da7c9ca1195b3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Affective disorders</topic><topic>Attention</topic><topic>Attention deficit hyperactivity disorder</topic><topic>Behavior problems</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Depressive Disorder - epidemiology</topic><topic>Developmental disabilities</topic><topic>Differential diagnosis</topic><topic>Down syndrome</topic><topic>Down's syndrome</topic><topic>Emotional disorders</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Hyperactivity</topic><topic>Incidence</topic><topic>Intellectual disabilities</topic><topic>Intellectual Disability - epidemiology</topic><topic>Interviews</topic><topic>Learning disabilities</topic><topic>Life events</topic><topic>Male</topic><topic>Mania</topic><topic>Medical diagnosis</topic><topic>Mental depression</topic><topic>Mental disorders</topic><topic>Mental health</topic><topic>Middle Aged</topic><topic>Mood</topic><topic>Population</topic><topic>Psychiatrists</topic><topic>Psychiatry</topic><topic>Schizophrenia</topic><topic>Scotland - epidemiology</topic><topic>Treatment needs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cooper, Sally-Ann</creatorcontrib><creatorcontrib>Smiley, Elita</creatorcontrib><creatorcontrib>Allan, Linda</creatorcontrib><creatorcontrib>Morrison, Jillian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Sociology Collection</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cooper, Sally-Ann</au><au>Smiley, Elita</au><au>Allan, Linda</au><au>Morrison, Jillian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study</atitle><jtitle>British journal of psychiatry</jtitle><addtitle>Br J Psychiatry</addtitle><date>2018-05</date><risdate>2018</risdate><volume>212</volume><issue>5</issue><spage>295</spage><epage>300</epage><pages>295-300</pages><issn>0007-1250</issn><eissn>1472-1465</eissn><abstract>Incidence and determinants of affective disorders among adults with intellectual disabilities are unknown.AimsTo investigate affective disorder incidence, and determinants of unipolar depression, compared with general population reports.
Prospective cohort study measuring mental ill health of adults with mild to profound intellectual disabilities living within a defined community, over 2 years.
There was 70% cohort retention (n = 651). Despite high mood stabiliser use (22.4%), 2-year incident mania at 1.1% is higher than the general population; 0.3% for first episode (standardised incident ratio (SIR) = 41.5, or 52.7 excluding Down syndrome). For any bipolar episode the SIR was 2.0 (or 2.5 excluding Down syndrome). Depression incidence at 7.2% is similar to the general population (SIR = 1.2), suggesting more enduring/undertreatment given the higher prevalence. Problem behaviours (odds ratio (OR) = 2.3) and life events (OR = 1.3) predict incident unipolar depression.
Depression needs improved treatment. Mania has received remarkably little attention in this population, despite high prevalence and incidence (similar to schizophrenia), and given the importance of clinician awareness for accurate differential diagnosis from attention-deficit hyperactivity disorder and problem behaviours.Declaration of interestNone.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>29540250</pmid><doi>10.1192/bjp.2018.12</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Applied Social Sciences Index & Abstracts (ASSIA); Alma/SFX Local Collection; Cambridge University Press Journals Complete |
| subjects | Adult Adults Affective disorders Attention Attention deficit hyperactivity disorder Behavior problems Bipolar disorder Bipolar Disorder - epidemiology Cohort analysis Cohort Studies Comorbidity Depressive Disorder - epidemiology Developmental disabilities Differential diagnosis Down syndrome Down's syndrome Emotional disorders Epidemiology Female Humans Hyperactivity Incidence Intellectual disabilities Intellectual Disability - epidemiology Interviews Learning disabilities Life events Male Mania Medical diagnosis Mental depression Mental disorders Mental health Middle Aged Mood Population Psychiatrists Psychiatry Schizophrenia Scotland - epidemiology Treatment needs |
| title | Incidence of unipolar and bipolar depression, and mania in adults with intellectual disabilities: prospective cohort study |
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