Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations
The therapeutic performance of cancer radiotherapy is often limited by the overexpression of glutathione (GSH) in tumors and low radiation sensitivity of cancerous cells. To address these issues, the facilely prepared histidine-capped gold nanoclusters (Au NCs@His) were adopted as a radiosensitizer...
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| Veröffentlicht in: | ACS applied materials & interfaces 2018-04, Vol.10 (13), p.10601-10606 |
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| container_title | ACS applied materials & interfaces |
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| creator | Zhang, Xiaodong Chen, Xiaokai Jiang, Yao-Wen Ma, Ningning Xia, Liu-Yuan Cheng, Xiaotong Jia, Hao-Ran Liu, Peidang Gu, Ning Chen, Zhan Wu, Fu-Gen |
| description | The therapeutic performance of cancer radiotherapy is often limited by the overexpression of glutathione (GSH) in tumors and low radiation sensitivity of cancerous cells. To address these issues, the facilely prepared histidine-capped gold nanoclusters (Au NCs@His) were adopted as a radiosensitizer with a high sensitization enhancement ratio of ∼1.54. On one hand, Au NCs@His can inherit the local radiation enhancement property of gold-based materials (external regulation); on the other hand, Au NCs@His can decrease the intracellular GSH level, thus preventing the generated reactive oxygen species (ROS) from being consumed by GSH, and arrest the cells at the radiosensitive G2/M phase (internal regulation). |
| doi_str_mv | 10.1021/acsami.8b00207 |
| format | Article |
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On one hand, Au NCs@His can inherit the local radiation enhancement property of gold-based materials (external regulation); on the other hand, Au NCs@His can decrease the intracellular GSH level, thus preventing the generated reactive oxygen species (ROS) from being consumed by GSH, and arrest the cells at the radiosensitive G2/M phase (internal regulation).</description><identifier>ISSN: 1944-8244</identifier><identifier>EISSN: 1944-8252</identifier><identifier>DOI: 10.1021/acsami.8b00207</identifier><identifier>PMID: 29542315</identifier><language>eng</language><publisher>United States: American Chemical Society</publisher><subject>Glutathione - chemistry ; Gold ; Humans ; Metal Nanoparticles ; Neoplasms ; Radiation-Sensitizing Agents</subject><ispartof>ACS applied materials & interfaces, 2018-04, Vol.10 (13), p.10601-10606</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a330t-d1739945a7cddf32e9a8541461e79db1c5a7052542a490447e3925e6abf71cd3</citedby><cites>FETCH-LOGICAL-a330t-d1739945a7cddf32e9a8541461e79db1c5a7052542a490447e3925e6abf71cd3</cites><orcidid>0000-0003-1773-2868 ; 0000-0001-8687-8348 ; 0000-0003-0047-337X ; 0000-0003-4137-3535</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/acsami.8b00207$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/acsami.8b00207$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29542315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Chen, Xiaokai</creatorcontrib><creatorcontrib>Jiang, Yao-Wen</creatorcontrib><creatorcontrib>Ma, Ningning</creatorcontrib><creatorcontrib>Xia, Liu-Yuan</creatorcontrib><creatorcontrib>Cheng, Xiaotong</creatorcontrib><creatorcontrib>Jia, Hao-Ran</creatorcontrib><creatorcontrib>Liu, Peidang</creatorcontrib><creatorcontrib>Gu, Ning</creatorcontrib><creatorcontrib>Chen, Zhan</creatorcontrib><creatorcontrib>Wu, Fu-Gen</creatorcontrib><title>Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations</title><title>ACS applied materials & interfaces</title><addtitle>ACS Appl. Mater. Interfaces</addtitle><description>The therapeutic performance of cancer radiotherapy is often limited by the overexpression of glutathione (GSH) in tumors and low radiation sensitivity of cancerous cells. To address these issues, the facilely prepared histidine-capped gold nanoclusters (Au NCs@His) were adopted as a radiosensitizer with a high sensitization enhancement ratio of ∼1.54. On one hand, Au NCs@His can inherit the local radiation enhancement property of gold-based materials (external regulation); on the other hand, Au NCs@His can decrease the intracellular GSH level, thus preventing the generated reactive oxygen species (ROS) from being consumed by GSH, and arrest the cells at the radiosensitive G2/M phase (internal regulation).</description><subject>Glutathione - chemistry</subject><subject>Gold</subject><subject>Humans</subject><subject>Metal Nanoparticles</subject><subject>Neoplasms</subject><subject>Radiation-Sensitizing Agents</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEFvGyEQRlGVqEmdXnuMOEaV1gWW9Zpj5bquJauRHN9XY5j1boTBBVaKL_3txbLjW08D4n3fiEfIF87GnAn-DXSEfT-ebhkTrP5A7rmSspiKStxcz1LekU8xvjI2KQWrPpI7oSopSl7dk78LOyRIXe8dFj_wYDH1bkcX3hr6G5zXdogJQ6StD3TuOnAaDZ2dRqBrML1PHQY4HGnqgh92HX05Ogy7PqZe0_lbzjqwFJyhS3e5rHE3WEh5ZXwgty3YiJ8vc0Q2P-eb2a9i9bxYzr6vCihLlgrD61IpWUGtjWlLgQqmleRywrFWZst1fmGVyJ8CqZiUNZZKVDiBbVtzbcoReTrXHoL_M2BMzb6PGq0Fh36IjWA8t4kpUxkdn1EdfIwB2-YQ-j2EY8NZc1LenJU3F-U58HjpHrZ7NFf83XEGvp6BHGxe_XByEP_X9g-SvI24</recordid><startdate>20180404</startdate><enddate>20180404</enddate><creator>Zhang, Xiaodong</creator><creator>Chen, Xiaokai</creator><creator>Jiang, Yao-Wen</creator><creator>Ma, Ningning</creator><creator>Xia, Liu-Yuan</creator><creator>Cheng, Xiaotong</creator><creator>Jia, Hao-Ran</creator><creator>Liu, Peidang</creator><creator>Gu, Ning</creator><creator>Chen, Zhan</creator><creator>Wu, Fu-Gen</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1773-2868</orcidid><orcidid>https://orcid.org/0000-0001-8687-8348</orcidid><orcidid>https://orcid.org/0000-0003-0047-337X</orcidid><orcidid>https://orcid.org/0000-0003-4137-3535</orcidid></search><sort><creationdate>20180404</creationdate><title>Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations</title><author>Zhang, Xiaodong ; Chen, Xiaokai ; Jiang, Yao-Wen ; Ma, Ningning ; Xia, Liu-Yuan ; Cheng, Xiaotong ; Jia, Hao-Ran ; Liu, Peidang ; Gu, Ning ; Chen, Zhan ; Wu, Fu-Gen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a330t-d1739945a7cddf32e9a8541461e79db1c5a7052542a490447e3925e6abf71cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Glutathione - chemistry</topic><topic>Gold</topic><topic>Humans</topic><topic>Metal Nanoparticles</topic><topic>Neoplasms</topic><topic>Radiation-Sensitizing Agents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Xiaodong</creatorcontrib><creatorcontrib>Chen, Xiaokai</creatorcontrib><creatorcontrib>Jiang, Yao-Wen</creatorcontrib><creatorcontrib>Ma, Ningning</creatorcontrib><creatorcontrib>Xia, Liu-Yuan</creatorcontrib><creatorcontrib>Cheng, Xiaotong</creatorcontrib><creatorcontrib>Jia, Hao-Ran</creatorcontrib><creatorcontrib>Liu, Peidang</creatorcontrib><creatorcontrib>Gu, Ning</creatorcontrib><creatorcontrib>Chen, Zhan</creatorcontrib><creatorcontrib>Wu, Fu-Gen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Xiaodong</au><au>Chen, Xiaokai</au><au>Jiang, Yao-Wen</au><au>Ma, Ningning</au><au>Xia, Liu-Yuan</au><au>Cheng, Xiaotong</au><au>Jia, Hao-Ran</au><au>Liu, Peidang</au><au>Gu, Ning</au><au>Chen, Zhan</au><au>Wu, Fu-Gen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2018-04-04</date><risdate>2018</risdate><volume>10</volume><issue>13</issue><spage>10601</spage><epage>10606</epage><pages>10601-10606</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>The therapeutic performance of cancer radiotherapy is often limited by the overexpression of glutathione (GSH) in tumors and low radiation sensitivity of cancerous cells. To address these issues, the facilely prepared histidine-capped gold nanoclusters (Au NCs@His) were adopted as a radiosensitizer with a high sensitization enhancement ratio of ∼1.54. 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| subjects | Glutathione - chemistry Gold Humans Metal Nanoparticles Neoplasms Radiation-Sensitizing Agents |
| title | Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations |
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