Role of Carbamylated Biomolecules in Human Diseases

Carbamylation (or carbamoylation) is a non‐enzymatic modification of biomolecules mediated by cyanate, a dissociation product of urea. Proteins are more sensitive to carbamylation. Two major sites of carbamylation reaction are: Nα‐amino moiety of a protein N‐terminus and the Nɛ‐amino moiety of prote...

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Veröffentlicht in:	IUBMB life 2018-04, Vol.70 (4), p.267-275
Hauptverfasser:	Badar, Asim, Arif, Zarina, Alam, Khursheed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arteriosclerosis biomolecules Carbamates - metabolism Carbamylation cyanate Disease diseases Enzymes - metabolism Erythropoietin Hemoglobin Homeostasis Hormones - metabolism Humans Hypoxia Insulin Lipoproteins, LDL - metabolism Low density lipoprotein Lysine Metabolic pathways Oxytocin Protein Processing, Post-Translational Proteins Proteins - metabolism Structure-function relationships Urea
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