National trends in management of localized prostate cancer: A population based analysis 2004‐2013
Purpose Recent years have brought many changes in the management of localized prostate cancer as national screening guidelines have been updated and diagnostic practice patterns evolved. We sought to better understand how the changing landscape influenced treatment utilization in the United States....
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| Veröffentlicht in: | The Prostate 2018-05, Vol.78 (7), p.512-520 |
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| container_title | The Prostate |
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| creator | Chen, Junchao Oromendia, Clara Halpern, Joshua A. Ballman, Karla V. |
| description | Purpose
Recent years have brought many changes in the management of localized prostate cancer as national screening guidelines have been updated and diagnostic practice patterns evolved. We sought to better understand how the changing landscape influenced treatment utilization in the United States.
Methods
We used the SEER database in this retrospective analysis of patients with clinically localized prostate cancer between 2004 and 2013. We evaluated utilization of primary treatment modalities over time with descriptive and trend analyses, and examined treatment utilization by cancer risk group and age at diagnosis.
Results
Of 398 074 patients in the analytic data set, 38% elected radiation therapy, 38% underwent radical prostatectomy, and 24% opted for expectant management. While in 2004 radiation treatment was almost twice as common as expectant management (42% vs 23%), by 2013 approximately equal percentages of patients were treated with each of the three modalities. Expectant management use increased over time, while the proportion of patients opting for surgery decreased remarkably with increasing age at diagnosis in intermediate‐ and higher‐risk disease. Among radiotherapy options, brachytherapy was most common among lower‐risk patients in 2004 but substantially decreased over time (P |
| doi_str_mv | 10.1002/pros.23496 |
| format | Article |
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Recent years have brought many changes in the management of localized prostate cancer as national screening guidelines have been updated and diagnostic practice patterns evolved. We sought to better understand how the changing landscape influenced treatment utilization in the United States.
Methods
We used the SEER database in this retrospective analysis of patients with clinically localized prostate cancer between 2004 and 2013. We evaluated utilization of primary treatment modalities over time with descriptive and trend analyses, and examined treatment utilization by cancer risk group and age at diagnosis.
Results
Of 398 074 patients in the analytic data set, 38% elected radiation therapy, 38% underwent radical prostatectomy, and 24% opted for expectant management. While in 2004 radiation treatment was almost twice as common as expectant management (42% vs 23%), by 2013 approximately equal percentages of patients were treated with each of the three modalities. Expectant management use increased over time, while the proportion of patients opting for surgery decreased remarkably with increasing age at diagnosis in intermediate‐ and higher‐risk disease. Among radiotherapy options, brachytherapy was most common among lower‐risk patients in 2004 but substantially decreased over time (P < 0.001).
Conclusions
Management of localized prostate cancer changed substantially over time in the United States. Utilization of expectant management has increased for men with low‐ and intermediate risk cancer. Among those who pursue curative therapy, younger men remain more likely to elect surgery whereas older men tend to choose radiotherapy. Further studies are needed to better characterize factors contributing to treatment selection.</description><identifier>ISSN: 0270-4137</identifier><identifier>EISSN: 1097-0045</identifier><identifier>DOI: 10.1002/pros.23496</identifier><identifier>PMID: 29542178</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Brachytherapy ; Brachytherapy - statistics & numerical data ; Cancer surgery ; Cancer therapies ; Data processing ; Diagnosis ; expectant management ; Humans ; Male ; Management ; Middle Aged ; Patients ; Prostate cancer ; Prostatectomy ; Prostatectomy - statistics & numerical data ; Prostatic Neoplasms - epidemiology ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms - therapy ; Radiation therapy ; radical prostatectomy ; radiotherapy ; Radiotherapy - statistics & numerical data ; Retrospective Studies ; SEER Program ; Surgery ; United States - epidemiology ; Urological surgery</subject><ispartof>The Prostate, 2018-05, Vol.78 (7), p.512-520</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3576-bdcecb113158718bd8a899b0e8d7b65496135bbbb5b83a3003f3e5d04d64b24f3</citedby><cites>FETCH-LOGICAL-c3576-bdcecb113158718bd8a899b0e8d7b65496135bbbb5b83a3003f3e5d04d64b24f3</cites><orcidid>0000-0003-1830-4494</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpros.23496$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpros.23496$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29542178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Junchao</creatorcontrib><creatorcontrib>Oromendia, Clara</creatorcontrib><creatorcontrib>Halpern, Joshua A.</creatorcontrib><creatorcontrib>Ballman, Karla V.</creatorcontrib><title>National trends in management of localized prostate cancer: A population based analysis 2004‐2013</title><title>The Prostate</title><addtitle>Prostate</addtitle><description>Purpose
Recent years have brought many changes in the management of localized prostate cancer as national screening guidelines have been updated and diagnostic practice patterns evolved. We sought to better understand how the changing landscape influenced treatment utilization in the United States.
Methods
We used the SEER database in this retrospective analysis of patients with clinically localized prostate cancer between 2004 and 2013. We evaluated utilization of primary treatment modalities over time with descriptive and trend analyses, and examined treatment utilization by cancer risk group and age at diagnosis.
Results
Of 398 074 patients in the analytic data set, 38% elected radiation therapy, 38% underwent radical prostatectomy, and 24% opted for expectant management. While in 2004 radiation treatment was almost twice as common as expectant management (42% vs 23%), by 2013 approximately equal percentages of patients were treated with each of the three modalities. Expectant management use increased over time, while the proportion of patients opting for surgery decreased remarkably with increasing age at diagnosis in intermediate‐ and higher‐risk disease. Among radiotherapy options, brachytherapy was most common among lower‐risk patients in 2004 but substantially decreased over time (P < 0.001).
Conclusions
Management of localized prostate cancer changed substantially over time in the United States. Utilization of expectant management has increased for men with low‐ and intermediate risk cancer. Among those who pursue curative therapy, younger men remain more likely to elect surgery whereas older men tend to choose radiotherapy. Further studies are needed to better characterize factors contributing to treatment selection.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brachytherapy</subject><subject>Brachytherapy - statistics & numerical data</subject><subject>Cancer surgery</subject><subject>Cancer therapies</subject><subject>Data processing</subject><subject>Diagnosis</subject><subject>expectant management</subject><subject>Humans</subject><subject>Male</subject><subject>Management</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Prostate cancer</subject><subject>Prostatectomy</subject><subject>Prostatectomy - statistics & numerical data</subject><subject>Prostatic Neoplasms - epidemiology</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms - therapy</subject><subject>Radiation therapy</subject><subject>radical prostatectomy</subject><subject>radiotherapy</subject><subject>Radiotherapy - statistics & numerical data</subject><subject>Retrospective Studies</subject><subject>SEER Program</subject><subject>Surgery</subject><subject>United States - epidemiology</subject><subject>Urological surgery</subject><issn>0270-4137</issn><issn>1097-0045</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAYhS0EoqWw8ADIEgtCSvltx7mwVRU3qQLEZY5sx0GpnAtxIlQmHoFn5ElwmsLAgBcvnz-fcxA6JDAlAPSsbio7pcyPgy00JhCHHoDPt9EYaAieT1g4QnvWLgEcDnQXjWjMfUrCaIzUrWjzqhQGt40uU4vzEheiFC-60GWLqwybSgmTv-sU9_-0otVYiVLp5hzPcF3VnVkbsBTWMe6pWdncYuoyfH18UiBsH-1kwlh9sLkn6Pny4ml-7S3urm7ms4WnGA8DT6ZKK0kIIzwKSSTTSERxLEFHaSgD7uoRxqU7XEZMMACWMc1T8NPAl9TP2ASdDF4X9LXTtk2K3CptjCh11dnEZfGJ6x1HDj3-gy6rrnHZe4pCELB4TZ0OlHLNbaOzpG7yQjSrhEDST5_0kyTr6R18tFF2stDpL_qztQPIALzlRq_-USX3D3ePg_QbgFaOCg</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Chen, Junchao</creator><creator>Oromendia, Clara</creator><creator>Halpern, Joshua A.</creator><creator>Ballman, Karla V.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1830-4494</orcidid></search><sort><creationdate>201805</creationdate><title>National trends in management of localized prostate cancer: A population based analysis 2004‐2013</title><author>Chen, Junchao ; Oromendia, Clara ; Halpern, Joshua A. ; Ballman, Karla V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3576-bdcecb113158718bd8a899b0e8d7b65496135bbbb5b83a3003f3e5d04d64b24f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brachytherapy</topic><topic>Brachytherapy - statistics & numerical data</topic><topic>Cancer surgery</topic><topic>Cancer therapies</topic><topic>Data processing</topic><topic>Diagnosis</topic><topic>expectant management</topic><topic>Humans</topic><topic>Male</topic><topic>Management</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Prostate cancer</topic><topic>Prostatectomy</topic><topic>Prostatectomy - statistics & numerical data</topic><topic>Prostatic Neoplasms - epidemiology</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms - therapy</topic><topic>Radiation therapy</topic><topic>radical prostatectomy</topic><topic>radiotherapy</topic><topic>Radiotherapy - statistics & numerical data</topic><topic>Retrospective Studies</topic><topic>SEER Program</topic><topic>Surgery</topic><topic>United States - epidemiology</topic><topic>Urological surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Junchao</creatorcontrib><creatorcontrib>Oromendia, Clara</creatorcontrib><creatorcontrib>Halpern, Joshua A.</creatorcontrib><creatorcontrib>Ballman, Karla V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Prostate</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Junchao</au><au>Oromendia, Clara</au><au>Halpern, Joshua A.</au><au>Ballman, Karla V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>National trends in management of localized prostate cancer: A population based analysis 2004‐2013</atitle><jtitle>The Prostate</jtitle><addtitle>Prostate</addtitle><date>2018-05</date><risdate>2018</risdate><volume>78</volume><issue>7</issue><spage>512</spage><epage>520</epage><pages>512-520</pages><issn>0270-4137</issn><eissn>1097-0045</eissn><abstract>Purpose
Recent years have brought many changes in the management of localized prostate cancer as national screening guidelines have been updated and diagnostic practice patterns evolved. We sought to better understand how the changing landscape influenced treatment utilization in the United States.
Methods
We used the SEER database in this retrospective analysis of patients with clinically localized prostate cancer between 2004 and 2013. We evaluated utilization of primary treatment modalities over time with descriptive and trend analyses, and examined treatment utilization by cancer risk group and age at diagnosis.
Results
Of 398 074 patients in the analytic data set, 38% elected radiation therapy, 38% underwent radical prostatectomy, and 24% opted for expectant management. While in 2004 radiation treatment was almost twice as common as expectant management (42% vs 23%), by 2013 approximately equal percentages of patients were treated with each of the three modalities. Expectant management use increased over time, while the proportion of patients opting for surgery decreased remarkably with increasing age at diagnosis in intermediate‐ and higher‐risk disease. Among radiotherapy options, brachytherapy was most common among lower‐risk patients in 2004 but substantially decreased over time (P < 0.001).
Conclusions
Management of localized prostate cancer changed substantially over time in the United States. Utilization of expectant management has increased for men with low‐ and intermediate risk cancer. Among those who pursue curative therapy, younger men remain more likely to elect surgery whereas older men tend to choose radiotherapy. Further studies are needed to better characterize factors contributing to treatment selection.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29542178</pmid><doi>10.1002/pros.23496</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1830-4494</orcidid></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Brachytherapy Brachytherapy - statistics & numerical data Cancer surgery Cancer therapies Data processing Diagnosis expectant management Humans Male Management Middle Aged Patients Prostate cancer Prostatectomy Prostatectomy - statistics & numerical data Prostatic Neoplasms - epidemiology Prostatic Neoplasms - pathology Prostatic Neoplasms - therapy Radiation therapy radical prostatectomy radiotherapy Radiotherapy - statistics & numerical data Retrospective Studies SEER Program Surgery United States - epidemiology Urological surgery |
| title | National trends in management of localized prostate cancer: A population based analysis 2004‐2013 |
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