Development and characterization of a camelid single‐domain antibody directed to human CD22 biomarker

CD22 is a B‐cell‐specific trans‐membrane glycoprotein, which is found on the surface of the most B cells and modulates their function, survival, and apoptosis. Recently, targeting this cell surface biomarker in B‐cell malignancies and disorders has attracted a lot of attention. The variable domain o...

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Veröffentlicht in:	Biotechnology and applied biochemistry 2018-09, Vol.65 (5), p.718-725
Hauptverfasser:	Faraji, Fatemeh, Tajik, Nader, Behdani, Mahdi, Shokrgozar, Mohammad Ali, Zarnani, Amir Hassan, Shahhosseini, Fatemeh, Habibi‐Anbouhi, Mahdi
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Antibodies Antigens Apoptosis Binding Biomarkers camelid single‐domain antibody CD22 CD22 antigen Cell surface Disorders Glycoproteins Homology Immunization Lymphocytes B Nanobodies Organic chemistry Phage display Phages Proteins VHH Western blotting
Online-Zugang:	Volltext
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