Epidermal Growth Factor Receptor Regulation of Ewing Sarcoma Cell Function

Objective: Ewing sarcoma (ES) is a type of childhood cancer probably arising from stem mesenchymal or neural crest cells. The epidermal growth factor receptor (EGFR) acts as a driver oncogene in many types of solid tumors. However, its involvement in ES remains poorly understood. Methods: Human SK-E...

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Veröffentlicht in:	Oncology 2018-01, Vol.94 (6), p.383-393
Hauptverfasser:	Kersting, Nathália , Kunzler Souza, Bárbara , Araujo Vieira, Igor , Pereira dos Santos, Rafael , Brufatto Olguins, Danielly , José Gregianin, Lauro , Tesainer Brunetto, André , Lunardi Brunetto, Algemir , Roesler, Rafael, Brunetto de Farias, Caroline, Schwartsmann, Gilberto
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Neoplasms - pathology Brain-Derived Neurotrophic Factor - metabolism Cancer Cell cycle Cell Line, Tumor Cell Proliferation - drug effects Childhood cancer Clinical Translational Research Cyclin D1 - metabolism EDTA Enzyme Inhibitors - pharmacology Epidermal Growth Factor - pharmacology Epidermal growth factors Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors G1 Phase Cell Cycle Checkpoints - drug effects Humans Mitogens Novels Phosphatidylinositol 3-Kinase - antagonists & inhibitors Phosphorylation - drug effects Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - metabolism Sarcoma Sarcoma, Ewing - pathology Signal Transduction - drug effects Stem cells Tumor proteins Tumor Suppressor Protein p53 - metabolism Tumors Tyrphostins - pharmacology
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