Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)
A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacet...
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| Veröffentlicht in: | Journal of Oleo Science 2006, Vol.55(4), pp.173-180 |
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| container_title | Journal of Oleo Science |
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| creator | YAGI, Nobuo OHKUBO, Katsuya OKUNO, Yoshiharu ODA, Yoshimitsu MIYAZAWA, Mitsuo |
| description | A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ. |
| doi_str_mv | 10.5650/jos.55.173 |
| format | Article |
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The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.</description><identifier>ISSN: 1345-8957</identifier><identifier>EISSN: 1347-3352</identifier><identifier>DOI: 10.5650/jos.55.173</identifier><language>eng</language><publisher>Tokyo: Japan Oil Chemists' Society</publisher><subject>MeIQ ; Peltophorum ; Peltophorum dasyrachi ; Salmonella typhimurium ; Salmonella typhimurium OY1001/1A2 ; SOS response ; Surangin C ; umu test ; Yellow batai</subject><ispartof>Journal of Oleo Science, 2006, Vol.55(4), pp.173-180</ispartof><rights>2006 by Japan Oil Chemists' Society</rights><rights>Copyright Japan Science and Technology Agency 2006</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5333-8cdd2d66c6836052ec04e16a2ea86d991900cb71a772a3919397a305188d7bc83</citedby><cites>FETCH-LOGICAL-c5333-8cdd2d66c6836052ec04e16a2ea86d991900cb71a772a3919397a305188d7bc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids></links><search><creatorcontrib>YAGI, Nobuo</creatorcontrib><creatorcontrib>OHKUBO, Katsuya</creatorcontrib><creatorcontrib>OKUNO, Yoshiharu</creatorcontrib><creatorcontrib>ODA, Yoshimitsu</creatorcontrib><creatorcontrib>MIYAZAWA, Mitsuo</creatorcontrib><creatorcontrib>Department of Applied Chemistry</creatorcontrib><creatorcontrib>Picaso Cosmetic Laboratory Limited</creatorcontrib><creatorcontrib>Faculty of Science and Engineering</creatorcontrib><creatorcontrib>Osaka Prefectural Institute of Public Health</creatorcontrib><creatorcontrib>Kinki University</creatorcontrib><title>Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)</title><title>Journal of Oleo Science</title><description>A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.</description><subject>MeIQ</subject><subject>Peltophorum</subject><subject>Peltophorum dasyrachi</subject><subject>Salmonella typhimurium</subject><subject>Salmonella typhimurium OY1001/1A2</subject><subject>SOS response</subject><subject>Surangin C</subject><subject>umu test</subject><subject>Yellow batai</subject><issn>1345-8957</issn><issn>1347-3352</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNpdkEtLxDAUhYso-Nz4CwqCqNDxpnl2JcPgCwRd6MJVyCQZJ6VtxqRF5t-bsT7Azb15fOfcw82yYwQTyihc1j5OKJ0gjreyPYQJLzCm5fbXmRaionw324-xBkjvlO9l02nXu3bo1ZvtnM5nvl35oTP5Ivg2f7VN4z_yueqVy8-ebNP71dKHoc2Niuug9NLF88NsZ6GaaI---0H2cnP9PLsrHh5v72fTh0JTjHEhtDGlYUwzgRnQ0mogFjFVWiWYqSpUAeg5R4rzUuF0xRVXGCgSwvC5FvggOx19V8G_Dzb2snVRp4Sqs36IsgSERcVQAk_-gbUfQpeySUQIgZLTqkzUxUjp4GMMdiFXwbUqrCUCudllUkVJqUy7TPDtCLfWOK0a3zWus3--pua-sX4TApgEoBRIalhCUqciAIFAgpDkdDU61XGz89-hKvRON_ZnKBnLRv3zo5cqSNvhT99Dkrg</recordid><startdate>2006</startdate><enddate>2006</enddate><creator>YAGI, Nobuo</creator><creator>OHKUBO, Katsuya</creator><creator>OKUNO, Yoshiharu</creator><creator>ODA, Yoshimitsu</creator><creator>MIYAZAWA, Mitsuo</creator><general>Japan Oil Chemists' Society</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>2006</creationdate><title>Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)</title><author>YAGI, Nobuo ; OHKUBO, Katsuya ; OKUNO, Yoshiharu ; ODA, Yoshimitsu ; MIYAZAWA, Mitsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5333-8cdd2d66c6836052ec04e16a2ea86d991900cb71a772a3919397a305188d7bc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>MeIQ</topic><topic>Peltophorum</topic><topic>Peltophorum dasyrachi</topic><topic>Salmonella typhimurium</topic><topic>Salmonella typhimurium OY1001/1A2</topic><topic>SOS response</topic><topic>Surangin C</topic><topic>umu test</topic><topic>Yellow batai</topic><toplevel>online_resources</toplevel><creatorcontrib>YAGI, Nobuo</creatorcontrib><creatorcontrib>OHKUBO, Katsuya</creatorcontrib><creatorcontrib>OKUNO, Yoshiharu</creatorcontrib><creatorcontrib>ODA, Yoshimitsu</creatorcontrib><creatorcontrib>MIYAZAWA, Mitsuo</creatorcontrib><creatorcontrib>Department of Applied Chemistry</creatorcontrib><creatorcontrib>Picaso Cosmetic Laboratory Limited</creatorcontrib><creatorcontrib>Faculty of Science and Engineering</creatorcontrib><creatorcontrib>Osaka Prefectural Institute of Public Health</creatorcontrib><creatorcontrib>Kinki University</creatorcontrib><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of Oleo Science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>YAGI, Nobuo</au><au>OHKUBO, Katsuya</au><au>OKUNO, Yoshiharu</au><au>ODA, Yoshimitsu</au><au>MIYAZAWA, Mitsuo</au><aucorp>Department of Applied Chemistry</aucorp><aucorp>Picaso Cosmetic Laboratory Limited</aucorp><aucorp>Faculty of Science and Engineering</aucorp><aucorp>Osaka Prefectural Institute of Public Health</aucorp><aucorp>Kinki University</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis)</atitle><jtitle>Journal of Oleo Science</jtitle><date>2006</date><risdate>2006</risdate><volume>55</volume><issue>4</issue><spage>173</spage><epage>180</epage><pages>173-180</pages><issn>1345-8957</issn><eissn>1347-3352</eissn><abstract>A ethanol extract from Yellow batai (Peltophorum dasyrachis) showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium OY1001/1A2 against the mutagen 2-amino-3,4-dimethylimidazo[4,5-f ]quinoline (MeIQ). The ethanol exract was re-extracted with chloroform, ethylacetate, butanol, and water. A chloroform fraction showed a suppressive effect. Suppressive compound against MeIQ in the chloroform fraction was isolated by SiO2 column chromatography and identified as surangin C (1) by FABMS, EIMS, and 1 D and 2 D NMR spectroscopy. Surangin C exhibited an inhibition of the SOS-inducing activity of MeIQ in the umu test. Gene expression was suppressed 59.5% at a concentration of 100 μM. The ID50 value (50% inhibition dose) of compound 1 was 67.9 μM. On the other hand, compound 1 showed weak suppressive effects of the SOS-inducing activity on activated MeIQ.</abstract><cop>Tokyo</cop><pub>Japan Oil Chemists' Society</pub><doi>10.5650/jos.55.173</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | MeIQ Peltophorum Peltophorum dasyrachi Salmonella typhimurium Salmonella typhimurium OY1001/1A2 SOS response Surangin C umu test Yellow batai |
| title | Antimutagenic Compound from Yellow batai (Peltophorum dasyrachis) |
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