The relationship of depressive symptoms and functional and structural markers of subclinical atherosclerosis: A systematic review and meta-analysis

The relationship of depressive symptoms and functional and structural markers of subclinical atherosclerosis: A systematic review and meta-analysis

Abstract Objectives The relationship of depressive symptoms and subclinical atherosclerosis remains controversial. We performed a systematic review and meta-analysis to evaluate the effect of depressive symptoms on the functional and structural markers of subclinical atherosclerosis as measured by c...

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Veröffentlicht in:European Journal of Preventive Cardiology 2018-05, Vol.25 (7), p.706-716
Hauptverfasser: Wu, Yupeng, Sun, Dandan, Wang, Bin, Li, Yanfeng, Ma, Yi
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container_issue 7
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container_title European Journal of Preventive Cardiology
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creator Wu, Yupeng
Sun, Dandan
Wang, Bin
Li, Yanfeng
Ma, Yi
description Abstract Objectives The relationship of depressive symptoms and subclinical atherosclerosis remains controversial. We performed a systematic review and meta-analysis to evaluate the effect of depressive symptoms on the functional and structural markers of subclinical atherosclerosis as measured by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and flow-mediated vasodilation (FMD). Methods A systematic literature search was performed electronically. Studies relating IMT, PWV or FMD to depressive symptoms were included. Standard/weighted mean differences (SMD/WMD) and corresponding 95% confidence intervals (95% CIs) were pooled in overall and subgroup analyses (age, sex, depression diagnosis, region, study design, site measured and sample size). Sensitivity analysis and publication bias were also conducted. Results Thirty-eight articles involving 5947 patients with depressive symptoms and 34,423 controls without depressive symptoms were included. Compared with controls without depressive symptoms, patients with depressive symptoms showed a significantly thicker IMT (SMD (95% CI) = 0.137 (0.047–0.227), p = 0.003), a higher PWV (SMD (95% CI) = 0.216 (0.139–0.293), p 
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We performed a systematic review and meta-analysis to evaluate the effect of depressive symptoms on the functional and structural markers of subclinical atherosclerosis as measured by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and flow-mediated vasodilation (FMD). Methods A systematic literature search was performed electronically. Studies relating IMT, PWV or FMD to depressive symptoms were included. Standard/weighted mean differences (SMD/WMD) and corresponding 95% confidence intervals (95% CIs) were pooled in overall and subgroup analyses (age, sex, depression diagnosis, region, study design, site measured and sample size). Sensitivity analysis and publication bias were also conducted. Results Thirty-eight articles involving 5947 patients with depressive symptoms and 34,423 controls without depressive symptoms were included. Compared with controls without depressive symptoms, patients with depressive symptoms showed a significantly thicker IMT (SMD (95% CI) = 0.137 (0.047–0.227), p = 0.003), a higher PWV (SMD (95% CI) = 0.216 (0.139–0.293), p &lt; 0.001) and a lower FMD (WMD (95% CI) = –2.554 (–3.709 to –1.399), p &lt; 0.001). When analyzing subgroups with age and female ratio, all results were still significant (p &lt; 0.05) except IMT and FMD in age &lt; 50 years subgroups (p &gt; 0.05). There was no statistical significance in sensitivity analysis and publication bias (p &gt; 0.05). Conclusions Depressive symptoms contributed toward subclinical atherosclerosis, and resulted in impaired functional and structural markers of subclinical atherosclerosis, which holds great promise in early prevention of cardiovascular disease.</description><identifier>ISSN: 2047-4873</identifier><identifier>EISSN: 2047-4881</identifier><identifier>DOI: 10.1177/2047487318764158</identifier><identifier>PMID: 29537293</identifier><language>eng</language><publisher>London, England: Oxford University Press</publisher><ispartof>European Journal of Preventive Cardiology, 2018-05, Vol.25 (7), p.706-716</ispartof><rights>The European Society of Cardiology 2018 2018</rights><rights>The European Society of Cardiology 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-528fe849934ed033c700836fe18b612ade5cb8e361f0a0d8177e9d6621bb3c533</citedby><cites>FETCH-LOGICAL-c439t-528fe849934ed033c700836fe18b612ade5cb8e361f0a0d8177e9d6621bb3c533</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/2047487318764158$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/2047487318764158$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>313,314,776,780,788,21798,27899,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29537293$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yupeng</creatorcontrib><creatorcontrib>Sun, Dandan</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Li, Yanfeng</creatorcontrib><creatorcontrib>Ma, Yi</creatorcontrib><title>The relationship of depressive symptoms and functional and structural markers of subclinical atherosclerosis: A systematic review and meta-analysis</title><title>European Journal of Preventive Cardiology</title><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><description>Abstract Objectives The relationship of depressive symptoms and subclinical atherosclerosis remains controversial. We performed a systematic review and meta-analysis to evaluate the effect of depressive symptoms on the functional and structural markers of subclinical atherosclerosis as measured by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and flow-mediated vasodilation (FMD). Methods A systematic literature search was performed electronically. Studies relating IMT, PWV or FMD to depressive symptoms were included. Standard/weighted mean differences (SMD/WMD) and corresponding 95% confidence intervals (95% CIs) were pooled in overall and subgroup analyses (age, sex, depression diagnosis, region, study design, site measured and sample size). Sensitivity analysis and publication bias were also conducted. Results Thirty-eight articles involving 5947 patients with depressive symptoms and 34,423 controls without depressive symptoms were included. Compared with controls without depressive symptoms, patients with depressive symptoms showed a significantly thicker IMT (SMD (95% CI) = 0.137 (0.047–0.227), p = 0.003), a higher PWV (SMD (95% CI) = 0.216 (0.139–0.293), p &lt; 0.001) and a lower FMD (WMD (95% CI) = –2.554 (–3.709 to –1.399), p &lt; 0.001). When analyzing subgroups with age and female ratio, all results were still significant (p &lt; 0.05) except IMT and FMD in age &lt; 50 years subgroups (p &gt; 0.05). There was no statistical significance in sensitivity analysis and publication bias (p &gt; 0.05). Conclusions Depressive symptoms contributed toward subclinical atherosclerosis, and resulted in impaired functional and structural markers of subclinical atherosclerosis, which holds great promise in early prevention of cardiovascular disease.</description><issn>2047-4873</issn><issn>2047-4881</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNqFkU1P3DAQhq0KVNCyd05VjkgorT-S2OG2QgUqIXFZzpHjTFjTfOGxQfs7-odxWNhDD-CDPWM97zuaGUJOGf3JmJS_OM1kpqRgShYZy9U3cjx_pZlS7GAfS3FEloiPNJ6Ccq7Ud3LEy1xIXopj8m-9gcRBp70dB9zYKRnbpIHJAaJ9hgS3_eTHHhM9NEkbBjNzuntL0btgfHAx7bX7Cw5nMYbadHawZqb8BtyIpptvixfJKhqihz6WM7Hss4WXN6sevE51NN5G7IQctrpDWL6_C3J_9Xt9eZPe3l3_uVzdpiYTpU9zrlpQWVmKDBoqhJGUKlG0wFRdMK4byE2tQBSspZo2Ks4MyqYoOKtrYXIhFuRs5zu58SkA-qq3aKDr9ABjwIpTJqSSZRzUgtAdamIj6KCtJmdj09uK0WreRvX_NqLkx7t7qHto9oKP2Ucg3QGoH6B6HIOL_eNnhuc7fgzT1-VfATS_oVk</recordid><startdate>20180501</startdate><enddate>20180501</enddate><creator>Wu, Yupeng</creator><creator>Sun, Dandan</creator><creator>Wang, Bin</creator><creator>Li, Yanfeng</creator><creator>Ma, Yi</creator><general>Oxford University Press</general><general>SAGE Publications</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20180501</creationdate><title>The relationship of depressive symptoms and functional and structural markers of subclinical atherosclerosis: A systematic review and meta-analysis</title><author>Wu, Yupeng ; Sun, Dandan ; Wang, Bin ; Li, Yanfeng ; Ma, Yi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-528fe849934ed033c700836fe18b612ade5cb8e361f0a0d8177e9d6621bb3c533</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yupeng</creatorcontrib><creatorcontrib>Sun, Dandan</creatorcontrib><creatorcontrib>Wang, Bin</creatorcontrib><creatorcontrib>Li, Yanfeng</creatorcontrib><creatorcontrib>Ma, Yi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European Journal of Preventive Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yupeng</au><au>Sun, Dandan</au><au>Wang, Bin</au><au>Li, Yanfeng</au><au>Ma, Yi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relationship of depressive symptoms and functional and structural markers of subclinical atherosclerosis: A systematic review and meta-analysis</atitle><jtitle>European Journal of Preventive Cardiology</jtitle><addtitle>Eur J Cardiovasc Prev Rehabil</addtitle><date>2018-05-01</date><risdate>2018</risdate><volume>25</volume><issue>7</issue><spage>706</spage><epage>716</epage><pages>706-716</pages><issn>2047-4873</issn><eissn>2047-4881</eissn><abstract>Abstract Objectives The relationship of depressive symptoms and subclinical atherosclerosis remains controversial. We performed a systematic review and meta-analysis to evaluate the effect of depressive symptoms on the functional and structural markers of subclinical atherosclerosis as measured by carotid intima-media thickness (IMT), pulse wave velocity (PWV) and flow-mediated vasodilation (FMD). Methods A systematic literature search was performed electronically. Studies relating IMT, PWV or FMD to depressive symptoms were included. Standard/weighted mean differences (SMD/WMD) and corresponding 95% confidence intervals (95% CIs) were pooled in overall and subgroup analyses (age, sex, depression diagnosis, region, study design, site measured and sample size). Sensitivity analysis and publication bias were also conducted. Results Thirty-eight articles involving 5947 patients with depressive symptoms and 34,423 controls without depressive symptoms were included. Compared with controls without depressive symptoms, patients with depressive symptoms showed a significantly thicker IMT (SMD (95% CI) = 0.137 (0.047–0.227), p = 0.003), a higher PWV (SMD (95% CI) = 0.216 (0.139–0.293), p &lt; 0.001) and a lower FMD (WMD (95% CI) = –2.554 (–3.709 to –1.399), p &lt; 0.001). When analyzing subgroups with age and female ratio, all results were still significant (p &lt; 0.05) except IMT and FMD in age &lt; 50 years subgroups (p &gt; 0.05). There was no statistical significance in sensitivity analysis and publication bias (p &gt; 0.05). Conclusions Depressive symptoms contributed toward subclinical atherosclerosis, and resulted in impaired functional and structural markers of subclinical atherosclerosis, which holds great promise in early prevention of cardiovascular disease.</abstract><cop>London, England</cop><pub>Oxford University Press</pub><pmid>29537293</pmid><doi>10.1177/2047487318764158</doi><tpages>11</tpages></addata></record>
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title The relationship of depressive symptoms and functional and structural markers of subclinical atherosclerosis: A systematic review and meta-analysis
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