Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings

Scope Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight. Methods and result...

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Veröffentlicht in:Molecular nutrition & food research 2018-05, Vol.62 (10), p.e1800060-n/a
Hauptverfasser: Barja‐Fernandez, Silvia, Moreno‐Navarrete, José María, Folgueira, Cintia, Xifra, Gemma, Sabater, Mònica, Castelao, Cecilia, FernØ, Johan, Leis, Rosaura, Diéguez, Carlos, Casanueva, Felipe F., Ricart, Wifredo, Seoane, Luisa M., Fernandez‐Real, José Manuel, Nogueiras, Rubén
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container_issue 10
container_start_page e1800060
container_title Molecular nutrition & food research
container_volume 62
creator Barja‐Fernandez, Silvia
Moreno‐Navarrete, José María
Folgueira, Cintia
Xifra, Gemma
Sabater, Mònica
Castelao, Cecilia
FernØ, Johan
Leis, Rosaura
Diéguez, Carlos
Casanueva, Felipe F.
Ricart, Wifredo
Seoane, Luisa M.
Fernandez‐Real, José Manuel
Nogueiras, Rubén
description Scope Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight. Methods and results Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight. Conclusion Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes. Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss.
doi_str_mv 10.1002/mnfr.201800060
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We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight. Methods and results Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight. Conclusion Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes. Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201800060</identifier><identifier>PMID: 29536615</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adult ; Angiopoietin ; Angiopoietin-like 4 Protein - blood ; ANGPTL‐4 ; BMI ; Body fat ; Body mass ; Body Weight ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Fasting ; Female ; Glucose ; Glucose Intolerance ; Glucose tolerance ; Humans ; Hypocaloric diet ; Inflammation ; Longitudinal Studies ; Male ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - diet therapy ; Patients ; Proteins ; Triglycerides ; Waist Circumference ; weight changes ; Weight Loss ; Weight reduction</subject><ispartof>Molecular nutrition &amp; food research, 2018-05, Vol.62 (10), p.e1800060-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH &amp; Co. 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We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight. Methods and results Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight. Conclusion Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes. Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. 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Moreno‐Navarrete, José María ; Folgueira, Cintia ; Xifra, Gemma ; Sabater, Mònica ; Castelao, Cecilia ; FernØ, Johan ; Leis, Rosaura ; Diéguez, Carlos ; Casanueva, Felipe F. ; Ricart, Wifredo ; Seoane, Luisa M. ; Fernandez‐Real, José Manuel ; Nogueiras, Rubén</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3682-d6bb4ce5e43dac287387e3ecbada458a266676dab016c0f8812996e274f331063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Angiopoietin</topic><topic>Angiopoietin-like 4 Protein - blood</topic><topic>ANGPTL‐4</topic><topic>BMI</topic><topic>Body fat</topic><topic>Body mass</topic><topic>Body Weight</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose Intolerance</topic><topic>Glucose tolerance</topic><topic>Humans</topic><topic>Hypocaloric diet</topic><topic>Inflammation</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - diet therapy</topic><topic>Patients</topic><topic>Proteins</topic><topic>Triglycerides</topic><topic>Waist Circumference</topic><topic>weight changes</topic><topic>Weight Loss</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barja‐Fernandez, Silvia</creatorcontrib><creatorcontrib>Moreno‐Navarrete, José María</creatorcontrib><creatorcontrib>Folgueira, Cintia</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Sabater, Mònica</creatorcontrib><creatorcontrib>Castelao, Cecilia</creatorcontrib><creatorcontrib>FernØ, Johan</creatorcontrib><creatorcontrib>Leis, Rosaura</creatorcontrib><creatorcontrib>Diéguez, Carlos</creatorcontrib><creatorcontrib>Casanueva, Felipe F.</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Seoane, Luisa M.</creatorcontrib><creatorcontrib>Fernandez‐Real, José Manuel</creatorcontrib><creatorcontrib>Nogueiras, Rubén</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium &amp; 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food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2018-05</date><risdate>2018</risdate><volume>62</volume><issue>10</issue><spage>e1800060</spage><epage>n/a</epage><pages>e1800060-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight. Methods and results Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight. Conclusion Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes. Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29536615</pmid><doi>10.1002/mnfr.201800060</doi><tpages>8</tpages></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adult
Angiopoietin
Angiopoietin-like 4 Protein - blood
ANGPTL‐4
BMI
Body fat
Body mass
Body Weight
Cross-Sectional Studies
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - blood
Fasting
Female
Glucose
Glucose Intolerance
Glucose tolerance
Humans
Hypocaloric diet
Inflammation
Longitudinal Studies
Male
Middle Aged
Obesity
Obesity - blood
Obesity - diet therapy
Patients
Proteins
Triglycerides
Waist Circumference
weight changes
Weight Loss
Weight reduction
title Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings
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