Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings
Scope Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight. Methods and result...
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Veröffentlicht in: | Molecular nutrition & food research 2018-05, Vol.62 (10), p.e1800060-n/a |
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creator | Barja‐Fernandez, Silvia Moreno‐Navarrete, José María Folgueira, Cintia Xifra, Gemma Sabater, Mònica Castelao, Cecilia FernØ, Johan Leis, Rosaura Diéguez, Carlos Casanueva, Felipe F. Ricart, Wifredo Seoane, Luisa M. Fernandez‐Real, José Manuel Nogueiras, Rubén |
description | Scope
Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight.
Methods and results
Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight.
Conclusion
Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes.
Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss. |
doi_str_mv | 10.1002/mnfr.201800060 |
format | Article |
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Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight.
Methods and results
Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight.
Conclusion
Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes.
Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201800060</identifier><identifier>PMID: 29536615</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Adult ; Angiopoietin ; Angiopoietin-like 4 Protein - blood ; ANGPTL‐4 ; BMI ; Body fat ; Body mass ; Body Weight ; Cross-Sectional Studies ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - blood ; Fasting ; Female ; Glucose ; Glucose Intolerance ; Glucose tolerance ; Humans ; Hypocaloric diet ; Inflammation ; Longitudinal Studies ; Male ; Middle Aged ; Obesity ; Obesity - blood ; Obesity - diet therapy ; Patients ; Proteins ; Triglycerides ; Waist Circumference ; weight changes ; Weight Loss ; Weight reduction</subject><ispartof>Molecular nutrition & food research, 2018-05, Vol.62 (10), p.e1800060-n/a</ispartof><rights>2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3682-d6bb4ce5e43dac287387e3ecbada458a266676dab016c0f8812996e274f331063</citedby><cites>FETCH-LOGICAL-c3682-d6bb4ce5e43dac287387e3ecbada458a266676dab016c0f8812996e274f331063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201800060$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201800060$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29536615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barja‐Fernandez, Silvia</creatorcontrib><creatorcontrib>Moreno‐Navarrete, José María</creatorcontrib><creatorcontrib>Folgueira, Cintia</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Sabater, Mònica</creatorcontrib><creatorcontrib>Castelao, Cecilia</creatorcontrib><creatorcontrib>FernØ, Johan</creatorcontrib><creatorcontrib>Leis, Rosaura</creatorcontrib><creatorcontrib>Diéguez, Carlos</creatorcontrib><creatorcontrib>Casanueva, Felipe F.</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Seoane, Luisa M.</creatorcontrib><creatorcontrib>Fernandez‐Real, José Manuel</creatorcontrib><creatorcontrib>Nogueiras, Rubén</creatorcontrib><title>Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight.
Methods and results
Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight.
Conclusion
Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes.
Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss.</description><subject>Adult</subject><subject>Angiopoietin</subject><subject>Angiopoietin-like 4 Protein - blood</subject><subject>ANGPTL‐4</subject><subject>BMI</subject><subject>Body fat</subject><subject>Body mass</subject><subject>Body Weight</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Fasting</subject><subject>Female</subject><subject>Glucose</subject><subject>Glucose Intolerance</subject><subject>Glucose tolerance</subject><subject>Humans</subject><subject>Hypocaloric diet</subject><subject>Inflammation</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - blood</subject><subject>Obesity - diet therapy</subject><subject>Patients</subject><subject>Proteins</subject><subject>Triglycerides</subject><subject>Waist Circumference</subject><subject>weight changes</subject><subject>Weight Loss</subject><subject>Weight reduction</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbFu2zAQhokiRZ04XTsGBLJksUvyKIrKZhixU8BNgtSdBYo6OQwkMRElGN76CH3GPEmk2vXQpdP9OHz34-5-Qr5wNuWMia9VXTRTwbhmjCn2gZxyxWEiOcDJUYtoRM5CeGYMuJDwiYxEEoFSPDol_qE0oTJ0drd8WK_efv2W1AU6C8FbZ1rM6da1T_Q-w-DaHTV1TpdlZ31AuvYlNqa2eE3njQ-hn_2BtnW-NuUfcOXrjWu73A2Nhat7sQnn5GNhyoCfD3VMfi5u1vPbyep--W0-W00sKC0mucoyaTFCCbmxQsegYwS0mcmNjLQRSqlY5SZjXFlWaM1FkigUsSwAOFMwJld735fGv3YY2rRywWJZmhp9F9L-ZRDrWIDu0ct_0GffNf3SAyVjGSU6kT013VN2OLbBIn1pXGWaXcpZOkSRDlGkxyj6gYuDbZdVmB_xv7_vAbkHtq7E3X_s0u93i0fgiYB3UOiVfQ</recordid><startdate>201805</startdate><enddate>201805</enddate><creator>Barja‐Fernandez, Silvia</creator><creator>Moreno‐Navarrete, José María</creator><creator>Folgueira, Cintia</creator><creator>Xifra, Gemma</creator><creator>Sabater, Mònica</creator><creator>Castelao, Cecilia</creator><creator>FernØ, Johan</creator><creator>Leis, Rosaura</creator><creator>Diéguez, Carlos</creator><creator>Casanueva, Felipe F.</creator><creator>Ricart, Wifredo</creator><creator>Seoane, Luisa M.</creator><creator>Fernandez‐Real, José Manuel</creator><creator>Nogueiras, Rubén</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201805</creationdate><title>Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings</title><author>Barja‐Fernandez, Silvia ; Moreno‐Navarrete, José María ; Folgueira, Cintia ; Xifra, Gemma ; Sabater, Mònica ; Castelao, Cecilia ; FernØ, Johan ; Leis, Rosaura ; Diéguez, Carlos ; Casanueva, Felipe F. ; Ricart, Wifredo ; Seoane, Luisa M. ; Fernandez‐Real, José Manuel ; Nogueiras, Rubén</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3682-d6bb4ce5e43dac287387e3ecbada458a266676dab016c0f8812996e274f331063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Angiopoietin</topic><topic>Angiopoietin-like 4 Protein - blood</topic><topic>ANGPTL‐4</topic><topic>BMI</topic><topic>Body fat</topic><topic>Body mass</topic><topic>Body Weight</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Fasting</topic><topic>Female</topic><topic>Glucose</topic><topic>Glucose Intolerance</topic><topic>Glucose tolerance</topic><topic>Humans</topic><topic>Hypocaloric diet</topic><topic>Inflammation</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - blood</topic><topic>Obesity - diet therapy</topic><topic>Patients</topic><topic>Proteins</topic><topic>Triglycerides</topic><topic>Waist Circumference</topic><topic>weight changes</topic><topic>Weight Loss</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barja‐Fernandez, Silvia</creatorcontrib><creatorcontrib>Moreno‐Navarrete, José María</creatorcontrib><creatorcontrib>Folgueira, Cintia</creatorcontrib><creatorcontrib>Xifra, Gemma</creatorcontrib><creatorcontrib>Sabater, Mònica</creatorcontrib><creatorcontrib>Castelao, Cecilia</creatorcontrib><creatorcontrib>FernØ, Johan</creatorcontrib><creatorcontrib>Leis, Rosaura</creatorcontrib><creatorcontrib>Diéguez, Carlos</creatorcontrib><creatorcontrib>Casanueva, Felipe F.</creatorcontrib><creatorcontrib>Ricart, Wifredo</creatorcontrib><creatorcontrib>Seoane, Luisa M.</creatorcontrib><creatorcontrib>Fernandez‐Real, José Manuel</creatorcontrib><creatorcontrib>Nogueiras, Rubén</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barja‐Fernandez, Silvia</au><au>Moreno‐Navarrete, José María</au><au>Folgueira, Cintia</au><au>Xifra, Gemma</au><au>Sabater, Mònica</au><au>Castelao, Cecilia</au><au>FernØ, Johan</au><au>Leis, Rosaura</au><au>Diéguez, Carlos</au><au>Casanueva, Felipe F.</au><au>Ricart, Wifredo</au><au>Seoane, Luisa M.</au><au>Fernandez‐Real, José Manuel</au><au>Nogueiras, Rubén</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2018-05</date><risdate>2018</risdate><volume>62</volume><issue>10</issue><spage>e1800060</spage><epage>n/a</epage><pages>e1800060-n/a</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
Angiopoietin‐like protein 4 (ANGPTL‐4) regulates plasma lipoprotein levels, but its relevance in human obesity and type 2 diabetes (T2D) is largely unknown. We aim to investigate the regulation of circulating ANGPTL‐4 levels in obesity, T2D, and after changes in body weight.
Methods and results
Circulating ANGPTL‐4 levels were measured in two different cohorts. First, in a cross‐sectional study, we evaluated ANGPTL‐4 levels in lean and obese patients with normoglycemia or with altered glucose tolerance (AGT; n = 282). Second, in a longitudinal intervention study, 51 obese participants were evaluated. A hypocaloric diet was prescribed, with follow‐up 2 years later. ANGPTL‐4 levels were significantly increased in obese patients with AGT compared to lean participants. Moreover, ANGPTL‐4 was positively correlated with BMI, waist circumference, fat mass, HbA1c, HOMA‐IR, fasting triglycerides, and with inflammatory markers. Participants gaining weight after the follow‐up showed increased ANGPTL‐4 levels in parallel to increased BMI, fat mass, and fasting glucose, while ANGPTL‐4 levels were reduced in participants losing weight.
Conclusion
Our data support a relevant role of ANGPTL‐4 in human obesity and its involvement in long‐term body weight changes.
Plasma ANGPTL‐4 levels in two different cohorts of patients are assessed. In a cross‐sectional study, we show that circulating ANGPTL‐4 is increased in obesity and particularly in obese patients with abnormal glucose tolerance. In a longitudinal study, plasma ANGPTL‐4 levels significantly increase after weight gain and tend to decrease after weight loss.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29536615</pmid><doi>10.1002/mnfr.201800060</doi><tpages>8</tpages></addata></record> |
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subjects | Adult Angiopoietin Angiopoietin-like 4 Protein - blood ANGPTL‐4 BMI Body fat Body mass Body Weight Cross-Sectional Studies Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - blood Fasting Female Glucose Glucose Intolerance Glucose tolerance Humans Hypocaloric diet Inflammation Longitudinal Studies Male Middle Aged Obesity Obesity - blood Obesity - diet therapy Patients Proteins Triglycerides Waist Circumference weight changes Weight Loss Weight reduction |
title | Plasma ANGPTL‐4 is Associated with Obesity and Glucose Tolerance: Cross‐Sectional and Longitudinal Findings |
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