Nano-chemotherapy using cationic liposome that strategically targets the cell membrane potential of pancreatic cancer cells with negative charge

Cationic liposome inhibited tumor enlargement of xenograft mouse models of pancreatic cancer by inducing apoptosis. [Display omitted] Negatively charged phosphatidylserine (PS) and sialic acid-containing glycosphingolipids (GM1) were observed to be over represented on the cell membranes of pancreati...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2018-04, Vol.28 (7), p.1161-1165
Hauptverfasser:	Motomura, Muneaki, Ichihara, Hideaki, Matsumoto, Yoko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Cationic liposomes Cations - chemistry Cell Line, Tumor Cell Membrane - drug effects Cell membrane potential Cell Proliferation - drug effects Cell Survival - drug effects Disease Models, Animal Dose-Response Relationship, Drug Glycosphingolipids - chemistry Humans In vivo Liposomes - chemistry Mice Mice, Inbred BALB C Molecular Structure N-Acetylneuraminic Acid - chemistry Nanoparticles - chemistry Neoplasms, Experimental - drug therapy Neoplasms, Experimental - pathology Pancreatic cancer Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - pathology Phosphatidylserines - chemistry Structure-Activity Relationship
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